Next Generation Pediatric Neuroimaging (NGPN) Feasibility

下一代儿科神经影像 (NGPN) 可行性

基本信息

批准号：
10011261
负责人：
Curtis Andrew Corum
金额：
$ 52.31万
依托单位：
CHAMPAIGN IMAGING, LLC
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10011261
关键词：
Acoustics Adult Algorithms Anesthesia procedures Anesthetics Animal Model Brain Brain imaging Child Childhood Clinic Clinical Clinical Research Cognition Communities Computer software Data Data Set Development Diffusion Dimensions Environment Family Functional Magnetic Resonance Imaging General Anesthesia Goals Head Hospitals Housing Human Image Institutional Review Boards Iowa Lead Loudness Magnetic Resonance Magnetic Resonance Imaging Methods Mission Modeling Modification Morphologic artifacts Motion Movement Neurosciences Noise Patients Performance Perfusion Phase Population Preparation Protocols documentation Protons Psychiatry RF coil Radial Ramp Recovery Research Research Personnel Residual state Resolution Risk Scanning Sedation procedure Series Signal Transduction Standardization Technology Testing Time Translating Universities Work brain research bulk motion clinical imaging clinical translation data space density design high dimensionality human imaging image reconstruction imaging biomarker improved neuroimaging next generation novel patient population pediatric patients prevent prototype reconstruction side effect signal processing success tool

项目摘要

Pediatric MR imaging is especially difficult due to motion-related artifacts in the images. Often this requires general anesthesia in the clinic, which has been shown recently to be detrimental to brain development. This places unique barriers on assessment of this population for both clinical and research purposes. In this application, we propose the development of the Next Generation Pediatric Neuroimaging (NGPN) technology, which will allow for high quality MR images to be collected in the presence of motion, thereby eliminating the need for general anesthesia while imaging. This technology will provide the MRI contrasts for proton density, T1, T2, T2*, diffusion, perfusion, and fMRI. The NGPN will be achieved by the development of novel hardware (RF coils and T/R switches), imaging sequences, and image reconstruction tools. These advancements will allow clinicians and researchers to image pediatric subjects in a safer, more reliable and efficient manner.

由于图像中与运动相关的伪影，小儿MR成像特别困难。经常这需要诊所的全身麻醉，最近已证明对大脑发育有害。这为评估而置于独特的障碍人口用于临床和研究目的。在此应用程序中，我们提出了开发下一代儿科神经影像学（NGPN）技术，该技术将允许在运动存在下收集高质量的MR图像成像时消除对全身麻醉的需求。这项技术将提供 MRI对比质子密度T1，T2，T2*，扩散，灌注和fMRI。 NGPN会可以通过开发新型硬件（RF线圈和T/R开关），成像来实现序列和图像重建工具。这些进步将使临床医生和研究人员以更安全，更可靠，更有效的方式对小儿受试者进行图像。