Vanderbilt Hypertension and Blood Pressure Regulation Program

范德比尔特高血压和血压调节计划

• 批准号: 10597621
• 负责人: David G Harrison
• 金额: $ 38.26万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10597621
• 关键词: Hypertension; blood pressure regulation; programs

ABSTRACT This is a new program to train the next generation of scientists in the fields of hypertension and blood pressure regulation. These conditions represent enormous health care problems. The new American Heart Association and American College of Cardiology Guidelines now classify almost 50% of the adult population as being hypertensive. Autonomic dysfunction, manifested by syncope, presyncope and postural intolerance, becomes increasingly common with age and is terribly disabling. Despite the commonality of these disorders, their precise etiology remains poorly defined. Moreover, they often associated with and share underlying mechanisms with other cardiovascular and metabolic disorders. It is therefore mandatory that we train and develop outstanding scientists to pursue these related areas of investigation. We propose to ultimately include 4 post-doctoral fellows and 2 predoctoral graduate students in Vanderbilt Hypertension and Blood Pressure Regulation (VHBPR) program. These trainees will be involved in three related facets of research. One has to do with understanding mechanisms of hypertension and end organ damage and the role inflammation and immune activation. Members of the VHBPR have led the field in defining mechanisms of immune activation in hypertension and related fields and this has evolved into a new understanding of the vascular, renal and cerebral dysfunction and damage that occurs in this and associated cardiovascular illnesses. Trainees involved in these programs will become familiar with an emerging area of immunology as it pertains to hypertension and cardiovascular diseases. The second important area of investigation is conducted by our Vanderbilt Autonomic Dysfunction Center. This center performs translational research involving laboratory, animal and clinical research. A third major area of investigation relates to bioinformatics of hypertension and drug responses. These studies are greatly facilitated by the BioVu database (the Vanderbilt DNA database) that contains DNA for >300,000 patients and the Synthetic derivative (de-identified medical records linked to BioVu) and are facilitated by our Division of Genetic Medicine and Center for Personalized Medicine. Our trainees will have the opportunity to initiate studies on medication-resistant hypertension, as more than 15,000 BioVU subjects with documented medication-resistant hypertension will have genome interrogation completed by 2018, including a large number of African American subjects. In addition to these laboratory research experiences, the VHBPR program includes seminars, didactic lectures and specialized course work devoted to career development, leadership, responsible conduct of research and work life balance. In addition to this core curriculum, trainees in specialized areas will participate in tailored coursework and workshops related to their specific areas of investigation. The ultimate goal is to train successful scientists that will successfully compete for future funding and who can pursue successful academic careers.

抽象的 这是一个新项目，旨在培训高血压和血液领域的下一代科学家 压力调节。这些情况代表了巨大的医疗保健问题。新美国之心 协会和美国心脏病学会指南现在对近 50% 的成人进行了分类 人口为高血压人群。自主神经功能障碍，表现为晕厥、晕厥前期和 随着年龄的增长，姿势不耐受变得越来越普遍，并且会造成严重的残疾。尽管 尽管这些疾病具有共性，但其确切病因仍不清楚。而且，他们经常 与其他心血管和代谢疾病相关并具有相同的潜在机制。这是 因此，我们必须培训和培养杰出的科学家来从事这些相关领域的研究 调查。我们建议最终包括 4 名博士后研究员和 2 名博士前研究生 范德比尔特高血压和血压调节（VHBPR）计划。这些实习生将 涉及三个相关方面的研究。一与了解高血压的机制有关 和终末器官损伤以及炎症和免疫激活的作用。 VHBPR 成员领导 定义高血压和相关领域免疫激活机制的领域，这已经 演变成对血管、肾脏和大脑功能障碍及其发生的损害的新认识 在这种疾病和相关的心血管疾病中。参与这些项目的学员将会变得熟悉 免疫学是一个新兴领域，与高血压和心血管疾病有关。这 第二个重要的调查领域是由我们的范德比尔特自主神经功能障碍中心进行的。这 中心开展涉及实验室、动物和临床研究的转化研究。第三大区域 研究涉及高血压和药物反应的生物信息学。这些研究极大地 由 BioVu 数据库（范德比尔特 DNA 数据库）提供支持，其中包含超过 300,000 名患者的 DNA 和合成衍生物（与 BioVu 关联的去识别化医疗记录），并由我们的促进 遗传医学部和个性化医学中心。我们的学员将有机会 启动药物抵抗性高血压研究，因为超过 15,000 名 BioVU 受试者患有 记录在案的耐药性高血压将在 2018 年完成基因组审讯， 包括大量非裔美国人主题。除了这些实验室研究 VHBPR 项目包括研讨会、教学讲座和专业课程 致力于职业发展、领导力、负责任的研究行为和工作与生活的平衡。在 除了核心课程外，专业领域的学员还将参加量身定制的课程， 与其具体研究领域相关的研讨会。最终目标是培养成功的科学家 谁将成功竞争未来的资金，谁可以追求成功的学术生涯。