Characterizing State Representation Impairments in People with Early Psychosis

早期精神病患者状态表征障碍的特征

• 批准号: 10597074
• 负责人: ANGUS W MACDONALD
• 金额: $ 54.24万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10597074
• 关键词: Adolescent and Young Adult; Algorithms; Behavior; Behavioral; Brain; Clinical; Data; Data Collection; Data Set; Electroencephalography; Equilibrium; Failure; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Heterogeneity; Human; Impairment; Intervention; Link; Maps; Measures; Modeling; Monkeys; Mus; Neuroanatomy; Neuronal Plasticity; Noise; Parietal; Participant; Patients; Pattern; Performance; Persons; Phase; Process; Psychophysiology; Psychoses; Quality of life; Scanning; Short-Term Memory; Symptoms; Testing; Time; Validation; Visit; aged; clinical heterogeneity; density; early psychosis; experimental study; functional magnetic resonance imaging/electroencephalography; guided inquiry; indexing; information processing; network models; neural; neural circuit; neurophysiology; nonhuman primate; novel; recruit; research clinical testing; treatment as usual

PROJECT SUMMARY: PROJECT 3 The purpose of PROJECT 3 is to determine how failures in information processing that supports state representation in neural circuits relate to clinical heterogeneity in early psychosis. To this end, we will: (a) Recruit people with early psychosis (N=125) and demographically similar healthy controls (N=125) aged 16-30 years; (b) Determine test-retest reliability of the DPX and Bandit tasks as assessments of state representation processes; (c) Characterize behavioral performance and neurophysiology at baseline using the DPX and Bandit tasks during simultaneous EEG-fMRI; (d) Follow patients for 6 months while they receive usual care, to delineate their clinical trajectories; (e) Repeat the behavioral and EEG-fMRI assessments after six months (N=100 retained per group). The data we acquire will allow us to examine the baseline relationships between clinical and experimental measures, and also to investigate how changes in clinical and experimental measures are related over a 6-month time period during a critical phase of illness. The overall goal of PROJECT 3 is to permit neural macro-circuit links in humans to the behavioral and neurophysiology experiments in monkeys and mice (PROJECTS 1 & 2). This will allow us to examine how state representation dysfunctions observed in early psychosis -- along with EEG and fMRI-derived neurophysiologic indices of activity timing, excitatory-inhibitory (E-I) balance, and noise -- relate to clinical heterogeneity at baseline, and to heterogeneity in 6-month clinical trajectories. In Aim 1, we compute the retest reliability of state representation measures. In Aim 2, we characterize and compare the features of behavior, EEG and fMRI in early psychosis and healthy controls during state representation processes. In Aim 3,we re- assess performance on the DPX and Bandit tasks during simultaneous EEG-FMRI, in order to characterize the course of state representation dysfunctions in early psychosis during the critical first 6 months of treatment. We will determine the extent to which changes in computational parameters derived from the COMPUTATIONAL CORE, and neurophysiologic measures related to activity timing, E-I balance, and noise (see TRANSLATIONAL NEUROPHYSIOLOGY CORE), map to distinct trajectories in quality of life using causal discovery analyses. We will also test whether trajectories can be predicted from baseline features. Additionally, our healthy control data set will permit us to explore normal patterns of stability vs. change as observed over 6 months in adolescents and young adults.

项目摘要：项目3 项目3的目的是确定如何支持状态的信息处理中的失败 神经回路中的表示与早期精神病的临床异质性有关。为此，我们将：（a） 招募早期精神病患者（n = 125）和人口统计学相似的健康对照（n = 125）16-30 年; （b）确定DPX和匪徒任务的重测可靠性作为国家表示的评估 过程； （c）使用DPX和 同时进行EEG-FMRI期间的强盗任务； （d）在患者接受常规护理时关注患者6个月， 描述其临床轨迹； （e）六个月后重复行为和EEG-FMRI评估 （n =每组保留100个）。我们获取的数据将使我们能够检查 临床和实验措施，并研究临床和实验的变化 在关键疾病的关键阶段，措施在6个月的时间内与措施有关。 项目3的总体目标是允许人类的神经宏电路链接到行为和行为和 猴子和小鼠的神经生理实验（项目1和2）。这将使我们能够检查如何 在早期精神病中观察到的状态表示功能 - 与脑电图和fmri衍生 活性计时，兴奋性抑制（E-I）平衡和噪声的神经生理指标 - 与临床有关 基线时异质性，以及在6个月的临床轨迹中的异质性。在AIM 1中，我们计算重新测试 国家代表措施的可靠性。在AIM 2中，我们表征和比较行为的特征， 在州代表过程中，早期精神病和健康对照中的脑电图和fMRI。在AIM 3中，我们重新 在同时脑电图中评估DPX和匪徒任务的性能，以表征 在关键的前6个月中，早期精神病的状态代表性功能障碍 治疗。我们将确定计算参数的变化的程度 计算核心和与活动时间，E-I平衡和噪声有关的神经生理测量 （请参阅转化神经生理学核心），使用使用 因果发现分析。我们还将测试是否可以从基线功能中预测轨迹。 此外，我们的健康控制数据集将使我们能够探索正常的稳定模式，而变化为 在青少年和年轻人中观察到超过6个月。