NINDS Network for Excellence in Neuroscience: Clinical Research Site at UC Davis

NINDS 神经科学卓越网络：加州大学戴维斯分校的临床研究中心

• 批准号: 10593639
• 负责人: Craig M. McDonald
• 金额: $ 27.76万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10593639
• 关键词: Address; Adult; Affect; Biological Markers; California; Capital; Characteristics; Childhood; Cities; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Clinical Trials Cooperative Group; Clinical Trials Network; Communities; Community Outreach; Country; Data; Data Coordinating Center; Development; Disease; Doctor of Philosophy; Environment; Foundations; Functional disorder; Future; Goals; Health; Health system; Industry; Informatics; Infrastructure; Institutional Review Boards; Link; Metadata; Mission; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Natural History; Neurosciences; Neurosciences Research; Outcome; Patient Recruitments; Patients; Personal Satisfaction; Persons; Phase II Clinical Trials; Population; Positioning Attribute; Preparation; Protocols documentation; Public Health; Quality of life; Registries; Research; Research Infrastructure; Research Personnel; Research Training; Resource Informatics; Resources; Site; Specialist; Standardization; System; Testing; Translational Research; United States National Institutes of Health; Universities; Vision; Work; burden of illness; career; catalyst; clinical outcome measures; clinical research site; community engagement; design; drug development; drug discovery; experience; improved; improved functioning; innovation; nervous system disorder; new therapeutic target; novel therapeutics; outreach; phase 2 study; public-private partnership; response; skills; sound; success; supportive environment; telehealth; therapeutic development; translational pipeline; translational research program

NINDS Network for Excellence in Neuroscience: Clinical Research Site at UC Davis (PI: Craig M. McDonald, MD; Sub‐PI: Michael Rogawski, MD, PhD) This proposal contributes to the NINDS Network for Excellence in Neuroscience (NeuroNEXT) by renewing a clinical research site at the University of California Davis Health System located in Sacramento, CA, the capital of the most populous state in the country and one of the most diverse and integrated cities in the U.S. The UC Davis NeuroNEXT clinical research site will continue to contribute to the mission of NINDS by reducing the burden of neurologic diseases, and contribute an infrastructure which expands the NINDS capability to test promising new therapies, increase the efficiency of clinical trials, and respond quickly as new opportunities arise to test promising treatments for people with neurological disorders. Our experience as an existing NeuroNEXT site, neuroscience research excellence at UC Davis ‐ the most comprehensive campus in the University of California system, a robust translational research infrastructure housed in a nationally recognized, experienced, and competitively renewed NIH CTSA (the UC Davis CTSC), neuroscience research excellence, an innovative collaborative drug development pipeline from the University of California UC BRAID Drug Discovery Consortium, a national center of excellence in telehealth strategically positioned to promote community outreach, an innovative informatics such as the Tethered Metadata Registry for case identification, and access to diverse patients with neurological disorders managed in a highly ranked regional health system with active clinical affiliations, all work synergistically to position UC Davis to continue to be an outstanding Clinical Research Site for the NeuroNEXT network. UC Davis NeuroNEXT aims to: 1) Leverage existing resources and expertise to serve as a NeuroNEXT hub for implementing multicenter neuroscience clinical trials, increasing the efficiency and quality of trials conducted at the UC Davis site; 2) Collaborate with the University of California UC BRAID Drug Discovery Consortium to serve as a core resource for NeuroNEXT and function as a catalyst for innovative therapeutic development across the translational spectrum; 3) Provide local and regional community outreach to improve patient recruitment and retention and fully integrate community partners into the translational research enterprise; 4) Efficiently utilize, diversify, and leverage innovative telehealth and informatics resources for clinical trials; and 5) Provide collaborative and innovative clinical research training and a supportive environment for diverse early‐career investigators to develop additional research skills and become independent clinical investigators. Our accomplishments to date – locally, regionally, and nationally – provide an outstanding foundation for future success.

NINDS Network for Excellence in Neuroscience: Clinical Research Site at UC Davis (PI: Craig M. McDonald, MD; Sub‐PI: Michael Rogawski, MD, PhD) This proposal contributes to the NINDS Network for Excellence in Neuroscience (NeuroNEXT) by renewing a clinical research site at the University of California Davis Health System located in Sacramento, CA, the capital of the most populous state在美国和美国最多样化和最融合的城市之一，加州大学戴维斯分校神经元临床研究网站将继续通过减少神经系统疾病的燃烧来为NIND的使命做出贡献疾病。 Our experience as an existing NeuroNEXT site, neuroscience research excellent at UC Davis ‐ the most comprehensive campus in the University of California system, a robust translated research infrastructure housed in a nationally recognized, experienced, and competitively renewed NIH CTSA (the UC Davis CTSC), neuroscience research excellent, an innovative collaborative drug development pipeline from the University of California UC BRAID Drug Discovery联合会是国家远程医疗卓越卓越中心，从战略上定位，旨在促进社区宣传，诸如绑扎的元数据注册表以进行病例识别，并访问具有在高度排名的区域卫生系统中管理的神经系统疾病的患者，并具有积极的临床分支机构，所有这些都可以在UC Davis的网络上进行临床研究。 UC Davis Neuronext的目标是：1）利用现有资源和专业知识作为实施多中心神经科学临床试验的Neuronext枢纽，从而提高了UC Davis站点进行试验的效率和质量； 2）与加利福尼亚大学UC Braid药物发现联盟合作，作为Neuronext的核心资源，并充当整个翻译光谱创新治疗发展的催化剂； 3）提供地方和区域社区的宣传，以改善患者招聘和保留率，并完全融入社区合作伙伴中，成为翻译的研究企业； 4）有效利用，多样化和利用创新的远程医疗和信息丰富的临床试验资源； 5）提供协作和创新的临床研究培训，并为多样化的早期职业研究人员多样化以发展额外的研究技能并成为独立的临床研究人员。迄今为止，我们在本地，地区和全国范围内取得的成就为未来成功提供了杰出的基础。

项目成果

The role of the neuromuscular medicine and physiatry specialists in the multidisciplinary management of neuromuscular disease.

神经肌肉医学和理疗专家在神经肌肉疾病的多学科治疗中的作用。

• DOI: 10.1016/j.pmr.2012.06.010
• 发表时间: 2012
• 期刊: Physical medicine and rehabilitation clinics of North America
• 影响因子: 1.7
• 作者: McDonald,CraigM;FowlerJr,WilliamM
• 通讯作者: FowlerJr,WilliamM