Neural Correlates of Location-Specific Contextual Threat Discrimination in Post-Traumatic Stress Disorders REV1

创伤后应激障碍中特定地点情境威胁歧视的神经相关性 REV1

• 批准号: 10597445
• 负责人: Benjamin Suarez-Jimenez
• 金额: $ 7.77万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-24 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10597445
• 关键词: Advanced Development; Anterior; Anxiety; Anxiety Disorders; Area; Biological Markers; Brain; Breathing; Characteristics; Communication; Coupled; Cues; Dangerousness; Data; Data Analyses; Detection; Development; Diagnosis; Diagnostic; Discrimination; Discrimination Learning; Disease; Distal; Emotional; Ensure; Environment; Feeling; Flowers; Fostering; Fright; Functional Magnetic Resonance Imaging; Functional disorder; Future; Galvanic Skin Response; Goals; Grant; Health; Heart Rate; Hippocampus (Brain); Hospitals; Human; Impairment; Intervention; Knowledge; Learning; Light; Location; Magnetic Resonance Imaging; Measurable; Measures; Mental disorders; Mentored Research Scientist Development Award; Mentorship; National Institute of Mental Health; Neurobiology; Outcome; Outcome Study; Participant; Pathway Analysis; Patients; Peripheral; Post-Traumatic Stress Disorders; Prediction of Response to Therapy; Prefrontal Cortex; Process; Psychological reinforcement; Psychopathology; Psychophysiology; Research; Research Personnel; Research Project Grants; Research Training; Rest; Risk; Role; Safety; Severities; Shock; Specificity; Stimulus Generalization; Symptoms; Time; Training; Trauma; Universities; advanced analytics; anxiety symptoms; anxiety-related disorders; authority; brain behavior; clinical phenotype; clinically relevant; conditioning; data acquisition; design; experience; imaging approach; imaging facilities; interdisciplinary approach; learned behavior; multimodality; neural circuit; neural correlate; neuroimaging; neuromechanism; novel; post-traumatic symptoms; programs; recruit; relating to nervous system; response; skills; stem; symptom cluster; symptomatology; therapy development; trauma exposure; virtual environment; virtual reality; Advanced Development; Anterior; Anxiety; Anxiety Disorders; Area; Biological Markers; Brain; Breathing; Characteristics; Communication; Coupled; Cues; Dangerousness; Data; Data Analyses; Detection; Development; Diagnosis; Diagnostic; Discrimination; Discrimination Learning; Disease; Distal; Emotional; Ensure; Environment; Feeling; Flowers; Fostering; Fright; Functional Magnetic Resonance Imaging; Functional disorder; Future; Galvanic Skin Response; Goals; Grant; Health; Heart Rate; Hippocampus (Brain); Hospitals; Human; Impairment; Intervention; Knowledge; Learning; Light; Location; Magnetic Resonance Imaging; Measurable; Measures; Mental disorders; Mentored Research Scientist Development Award; Mentorship; National Institute of Mental Health; Neurobiology; Outcome; Outcome Study; Participant; Pathway Analysis; Patients; Peripheral; Post-Traumatic Stress Disorders; Prediction of Response to Therapy; Prefrontal Cortex; Process; Psychological reinforcement; Psychopathology; Psychophysiology; Research; Research Personnel; Research Project Grants; Research Training; Rest; Risk; Role; Safety; Severities; Shock; Specificity; Stimulus Generalization; Symptoms; Time; Training; Trauma; Universities; advanced analytics; anxiety symptoms; anxiety-related disorders; authority; brain behavior; clinical phenotype; clinically relevant; conditioning; data acquisition; design; experience; imaging approach; imaging facilities; interdisciplinary approach; learned behavior; multimodality; neural circuit; neural correlate; neuroimaging; neuromechanism; novel; post-traumatic symptoms; programs; recruit; relating to nervous system; response; skills; stem; symptom cluster; symptomatology; therapy development; trauma exposure; virtual environment; virtual reality

Posttraumatic stress disorder (PTSD) is a highly prevalent and debilitating disorder. Despite efforts to characterize the pathophysiology of PTSD, no measurable indicators have been established to aid in diagnosis, treatment development, and prediction of treatment response. This K01 presents a program for research and training that will support the applicant on a path towards becoming an independent investigator, focused on the underlying neural mechanisms of learning valence discrimination within an environment using location-specific information through an interdisciplinary approach. The training plan builds on the candidate’s prior training and experience and capitalizes on a mentorship team and a research environment to foster development of the candidate’s expertise in 1) the understanding of neural and psychophysiological profiles related to PTSD, 2) gaining deeper proficiency in multimodal magnetic resonance imaging (MRI) data acquisition and analysis, 3) the understanding of mental disorder symptomatology and diagnosis & expertise in patient-related research, and 4) responsible conduct in scientific research. This research project will use a novel virtual reality task, created by the applicant and validated in healthy humans, to assess brain activity differences between patients with PTSD (n=30), trauma-exposed healthy controls (TEHC, n=30), and no trauma-exposed health controls (HC, n=30). A multimodal MRI approach (functional, resting-state, and structural MRI), will be used aiming to clarify the neural mechanisms underlying contextual threat discrimination in PTSD. Also, the fMRI will be coupled with peripheral measures of anxiety (e.g., skin conductance response, heart rate, breathing, pupillometry), subjective ratings of anxiety, and symptom clusters of PTSD. This research will be conducted at the University of Rochester, an optimal location due to the hospital and access to patients with PTSD, and imaging facilities. The results of the proposed research will be vital to clarify the process of discrimination of contextual threat in patients afflicted by anxiety disorders and PTSD and will lead to future R01 grants examining other threat-related learning processes across anxiety and trauma-related disorders. Together, the research and training experiences and expertise developed through this K01 award will support the applicant’s transition to research independence and ensure the applicant becomes a leading authority in the specific role of brain areas needed for threat learning and discrimination within an environment and how they break down in mental disorders.

创伤后应激障碍（PTSD）是一种高度普遍且令人衰弱的疾病。尽管努力 特征是PTSD的病理生理学，尚未建立可测量的指标来帮助诊断， 治疗发展和治疗反应的预测。该K01提出了一个研究计划， 培训将支持申请人成为一名独立研究者的道路，重点是 使用特定于位置的环境中学习价歧视的潜在神经机制 通过跨学科的方法进行信息。培训计划以候选人的先前培训为基础， 经验并利用心态团队和研究环境，以促进发展 候选人在1）对与PTSD有关的神经和心理生理概况的理解，2） 获得更深入的多模式磁共振成像（MRI）数据采集和分析的熟练程度，3） 对与患者有关的研究的精神障碍症状以及诊断和专业知识的理解，以及 4）科学研究中负责任的行为。该研究项目将使用新颖的虚拟现实任务，创建 通过适用和在健康人中得到证实的，以评估患者的大脑活动差异 PTSD（n = 30），受创伤暴露的健康对照（TEHC，n = 30），没有暴露创伤的健康控制（HC， n = 30）。多式联运MRI方法（功能，静止状态和结构MRI）将用于澄清 PTSD中背景威胁歧视的基础神经机制。另外，fMRI将与 动画的外围测量（例如，皮肤电导反应，心率，呼吸，化学计量法），主观 动画的评分和PTSD的症状簇。这项研究将在罗切斯特大学进行 由于医院并与PTSD和成像设施的患者接触，因此是最佳位置。结果 拟议的研究对于阐明患者歧视情境威胁的过程至关重要 通过焦虑症和PTSD，将导致未来的R01赠款检查其他与威胁有关的学习 跨焦虑和创伤相关疾病的过程。一起研究和培训经验以及 通过这项K01奖开发的专业知识将支持申请人过渡到研究独立性和 确保申请人成为威胁学习所需的大脑领域特定作用的领先权威 以及环境中的歧视以及它们如何分解精神障碍。