Relationship of Formal Exercise Interventions, Sleep, and Inflammation Markers in People Living with HIV

HIV 感染者的正式运动干预、睡眠和炎症标志物的关系

• 批准号: 10593050
• 负责人: Christine Horvat Davey
• 金额: $ 13.07万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-19 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10593050
• 关键词: Academia; Aerobic Exercise; Affect; Age; Biological Markers; Caffeine; Caring; Chronic Disease; Chronically Ill; Clinical Investigator; Clinical Trials; Coronary Arteriosclerosis; Coupled; Data; Development; Diabetes Mellitus; Drowsiness; Educational Intervention; Elderly; Enrollment; Environment; Exercise; General Population; Goals; HIV; HIV antiretroviral; HIV diagnosis; Habits; Health; Health Promotion; Heart Rate; Hygiene; Hypertension; Inadequate Sleep Hygiene; Inflammation; Inflammatory; Interferons; Interleukin-1 beta; Interleukin-10; Interleukin-13; Interleukin-2; Interleukin-4; Interleukin-6; Interleukin-8; Interleukins; Interval training; Intervention; Interview; Knowledge; Maximum Heart Rate; Measures; Medical; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Mission; National Institute of Nursing Research; Obesity; Older Population; Outcome; Parents; Pathway interactions; Patient Self-Report; Patients; Performance; Persons; Physical Function; Physical activity; Pilot Projects; Play; Population; Positioning Attribute; Randomized; Reporting; Research; Research Activity; Research Support; Resources; Role; Schedule; Science; Sleep; Sleep Deprivation; Sleep disturbances; Sleeplessness; Specific qualifier value; Surveys; Symptoms; TNF gene; Telephone Interviews; Training; Training Activity; United States; Universities; Walking; actigraphy; antiretroviral therapy; career; comorbidity; compare effectiveness; digital; exercise intensity; exercise intervention; experience; group intervention; implementation intervention; improved; improvement on sleep; inflammatory marker; innovation; insight; laboratory experience; modifiable behavior; mortality; multi-component intervention; multiplex assay; poor health outcome; poor sleep; recruit; research study; resistance exercise; skill acquisition; skills; sleep health; sleep quality; study population; symptom science; systemic inflammatory response

Project Summary/Abstract: Approximately half of all people living with HIV (PWH) in the United States are age 50 years and older. Older PWH are diagnosed with comorbidities such as obesity, hypertension, and diabetes at an earlier age, which contributes to poorer health outcomes including poor sleep quality. Poor sleep quality affects up to 75% of PWH and leads to poor outcomes, including decrease in performance of daily activities and increased mortality, but is a modifiable behavior. Sleep hygiene habits (i.e. bedroom environment, sleep schedule, caffeine) can impact sleep quality, but limited evidence exists regarding sleep hygiene habits in PWH. Systemic inflammation markers IL-10, IL-13, IFN-y, and TNF-α are associated with sleep disturbance in PWH, while CRP, TNF-α, IL-1β, IL-6, and IL-13 are associated with impaired sleep quality in other comorbid populations. Less physical activity is associated with increased inflammation. The collective or interacting impact of poor sleep quality and low levels of physical activity on inflammation may be stronger than either independent factor. In turn, it is vital to examine the causal pathway of the relation between physical activity through exercise interventions, sleep and inflammation in order to help mitigate poor sleep quality in PWH. The purpose of this study is to examine sleep hygiene habits in older PHW through in-depth interviews in order to understand the patient perspective of sleep quality and to characterize the effects of two exercise interventions, high-intensity interval training (HIIT) and continuous moderate-intensity exercise (CME), on sleep and inflammation in older PWH. We propose the following aims: AIM 1. Examine sleep hygiene habits in older PWH. AIM 2. Compare the effectiveness of HIIT and CME exercise interventions on sleep in older PWH. AIM 3. Quantify inflammation markers associated with sleep quality (self-report surveys) in older PWH at baseline, between (week 8) and after exercise interventions (HIIT and CME) (week 16). The proposed research is consistent with the National Institute for Nursing Research (NINR) mission to support research which uses biomarkers to assess symptoms and use of innovative interventions to mitigate symptom burden. My short-term goal for the K23 award is to acquire the necessary skills and training to increase my knowledge about sleep and the role exercise interventions and inflammation play in sleep quality. The K23 award will allow me to have a mentored training environment that will serve as a pathway to my long- term career goal of becoming an independent clinical investigator in symptom science developing multimodal interventions to mitigate poor sleep quality across comorbid conditions, including PWH. My specific training activities, ranging from coursework to direct exercise intervention and laboratory training, will allow me to develop new expertise. Case Western Reserve University provides an optimal environment with the necessary resources and facilities to complete this proposed research and facilitate my immediate and long term goals.

项目摘要/摘要： 在美国，大约有一半的艾滋病毒（PWH）年龄较大。 PWH被诊断为合并症，例如肥胖，高血压和糖尿病，年龄较早， 促成较差的健康状况，包括睡眠质量不佳。 PWH并导致结果不佳，包括日常活动的表现减少并增加 死亡率，但是一种可修改的行为 咖啡因）可能会影响睡眠质量，但是关于PWH中的睡眠卫生习惯有限。 全身炎症标记IL-10，IL-13，IFN-Y和TNF-α与PWH中的睡眠障碍有关 而CRP，TNF-α，IL-1β，IL-6和IL-13和IL-13在其他合并症中是缔合的睡眠质量 种群较少的体育活动与炎症增加有关。 睡眠质量差和体育锻炼水平低的影响可能比任何一个都要强大 独立因素。 通过运动干预，睡眠和炎症，以帮助减轻PWH的睡眠质量不佳。 这项研究的目的是通过深入的访谈检查较旧的PHW的睡眠习惯 为了了解患者的睡眠质量观点并表征两种运动的影响 干预措施，高强度间歇训练（HIIT）和连续中等强度练习（CME） 和较老的PWH中的炎症。 AIM 1.较老的PWH中的检查睡眠习惯。 AIM 2。比较HIIT和CME运动干预对较旧PWH的睡眠的有效性。 AIM 3。量化与较老PWH相关的与睡眠质量（自我报告调查）相关的炎症标记 基线，（第8周）和运动干预后（HIIT和CME）（第16周）。 拟议的研究也与国家护理研究所（NINR）任务一致 支持研究使用生物标志物评估症状和使用解释干预措施以减轻症状的研究 症状负担。 提高我对睡眠以及运动干预措施和睡眠质量发炎的知识。 K23奖Willow我将接受指导的培训培训。 成为症状科学独立临床研究者的职业职业目标发展了多模式 在合并症的情况下减轻睡眠质量不佳的干预措施包括我的特定培训 从课程到直接间隔和实验室培训的活动，将使我能够 开发新的专业知识。 资源和设施涂抹研究，并促进我的成熟和长期目标。

项目成果

Research and Quality Improvement: How Can They Work Together?

研究和质量改进：它们如何协同工作？

• 发表时间: 2022
• 期刊: Nephrology nursing journal : journal of the American Nephrology Nurses' Association
• 作者: Paulus,AmberB;Davey,ChristineHorvat;Feldner,KatieD
• 通讯作者: Feldner,KatieD

Socioeconomic Deprivation, Sleep Duration, and Mental Health during the First Year of the COVID-19 Pandemic.

• DOI: 10.3390/ijerph192114367
• 发表时间: 2022-11-03
• 期刊: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
• 作者: Griggs, Stephanie;Horvat Davey, Christine;Howard, Quiana;Pignatiello, Grant;Duwadi, Deepesh
• 通讯作者: Duwadi, Deepesh

Comparison of diet, muscle strength, steps per day and symptoms in people with HIV and HIV-negative peers.

• DOI: 10.1002/nur.22202
• 发表时间: 2022-03
• 期刊: Research in nursing & health
• 影响因子: 2
• 作者: Davey CH;Trinh V;Schexnayder J;Longenecker CT;Webel A
• 通讯作者: Webel A