Determining the role of social reward learning in social anhedonia in first-episode psychosis using motivational interviewing as a probe in a perturbation-based neuroimaging approach

使用动机访谈作为基于扰动的神经影像学方法的探索，确定社交奖励学习在首发精神病社交快感缺乏中的作用

• 批准号: 10594181
• 负责人: Michael F. Green
• 金额: $ 76.57万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2027-10-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10594181
• 关键词: Affect; Anhedonia; Anterior; Behavioral; Biological Markers; Clinical; Conceptions; Dorsal; Elements; Functional Magnetic Resonance Imaging; Future; Group Interviews; Individual; Interpersonal Relations; Intervention; Knowledge; Learning; Measures; Mechanics; Mental disorders; Methods; Neurosciences; Participant; Pathway interactions; Phenotype; Population; Positive Reinforcements; Prefrontal Cortex; Process; Psychoses; Psychotic Disorders; Public Health; Randomized; Reporting; Rewards; Role; Sampling; Seminal; Site; Social Functioning; Social Interaction; Specificity; Theoretical model; Time; Ventral Striatum; Work; affective neuroscience; behavior change; cingulate cortex; design; early psychosis; experience; first episode psychosis; group intervention; hedonic; indexing; insight; interest; motivational enhancement therapy; neural; neurobehavioral; neuroimaging; novel; nutrition; pleasure; psychotic; recruit; response; severe mental illness; sex; social; social influence; theories

Social anhedonia—a reduced tendency to enjoy interpersonal relationships and/or reduced interest in social interactions—poses a significant public health challenge. It is considered one of the most pervasive and debilitating features of severe mental illness, including psychosis. Social anhedonia substantially influences social functioning in psychosis, but currently there are no available treatments that target this debilitating hedonic deficit. Our limited understanding of the underlying mechanisms of social anhedonia presents a major obstacle for developing and evaluating interventions that target social anhedonia. This application aims to tackle this lack of knowledge by probing a process that is hypothesized to be central to social anhedonia: disrupted social reward learning. We developed our hypothesis from two complementary lines of work: a theoretical model of social anhedonia in psychosis and a growing body of work from affective neuroscience and behavioral neuroscience. To examine this hypothesized relationship between social reward learning and social anhedonia, this two-site study will recruit a sample enriched for social anhedonia (i.e., individuals who are within two years of their first psychotic episode) and employ a perturbation-based neuroimaging approach. The specificity of the relationship between reduced sensitivity to social reward and social anhedonia will be examined in two ways. First, we will employ two social reward learning tasks, each with both social and nonsocial reward conditions. Second, we will perturb social reward learning using Motivational Interviewing as a probe that is designed to increase sensitivity specifically to social reward. Participants will be randomized 1:1 to MI or a time- and format-matched control probe. At pre- and post-probe, participants will perform two social reward learning tasks in the scanner. We will examine the relationship between sensitivity to social reward and reduced subjective experience of social pleasure at both the behavioral and neural levels. The findings of this project will allow direct inferences about underlying mechanisms beyond demonstrating only the cross-sectional correlations between social reward sensitivity and social anhedonia. Thus, the findings of this project will provide valuable insights into the mechanistic pathways of social anhedonia and could provide novel neurobehavioral phenotypes that can serve as targets and biomarkers for developing novel treatments. Further, social anhedonia is not limited to severe mental illness, as some individuals with other mental disorders and also without mental illness report social anhedonia. The findings of this project will be valuable for our future efforts to determine whether the same underlying mechanism is related to social anhedonia across conditions and populations or not.

社会狂欢 - 享有人际关系和/或对社会兴趣的趋势减少了 互动 - 提出重大的公共卫生挑战。它被认为是最普遍的之一 严重精神疾病的特征，包括精神病。社会狂热的影响很大 精神病中的社会功能，但目前尚无针对这种衰弱的可用治疗方法 享乐国防。我们对社会Anhedonia的潜在机制的有限理解提出了一个主要的 制定和评估针对社会狂欢的干预措施的障碍。该应用程序旨在 通过探测一个被认为是社会抗议的过程的过程来解决这种缺乏知识： 破坏了社会奖励学习。 我们从两种完整的工作方面提出了假设：社会anhedonia的理论模型 在精神病和情感神经科学和行为神经科学的工作中越来越多的工作。到 检查社会奖励学习与社会anhedonia之间的这种假设的关系，这是这个两个站点 研究将招募一个富含社会anhedonia的样本 精神病发作）和员工一种基于扰动的神经影像学方法。关系的特异性 在降低对社会奖励的敏感性和社会anhedonia之间，将通过两种方式进行检查。首先，我们会的 员工两项社会奖励学习任务，每个任务均具有社会和非社会奖励条件。第二，我们 将使用动机访谈作为旨在增加的调查的社交奖励学习 特别对社会奖励的敏感性。 参与者将以1：1的方式随机分配给MI或时间和格式匹配的对照探针。在新事件和后期， 参与者将在扫描仪中执行两项社会奖励学习任务。我们将检查关系 在对社会奖励的敏感性和减少社会快乐的主题经验之间 行为和神经水平。该项目的发现将允许有关基础的直接推断 仅证明社会奖励敏感性与 社交狂欢。这是该项目的发现将为机械途径提供宝贵的见解 社会狂欢节，可以提供新型的神经行为表型，可以用作目标和 生物标志物用于开发新型治疗方法。此外，社会抗议不仅限于严重的精神疾病， 作为某些患有其他精神障碍的人，也没有精神疾病，也报告了社会抗议。 该项目的发现对于我们将来的努力确定同一基础是否有价值 机制与是否在条件和人群中与社会抗议有关。