Motivating Occupational Virtual Experiences In Therapy for kids

激发儿童治疗中的职业虚拟体验

• 批准号: 10264174
• 负责人: Richard J. Adams
• 金额: $ 92.8万
• 依托单位: BARRON ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10264174
• 关键词: Address; Adherence; Affect; Award; Blinded; Brain Injuries; Cerebral Palsy; Child; Childhood; Childhood stroke; Clinical; Clinical Research; Clinical Trials; Computer software; Development; Disease; Elements; Evidence based treatment; Exercise; Goals; Gold; Hand functions; Healthcare; Hemiplegia; Home; Human; Improve Access; Intervention; Interview; Learning; Marketing; Measures; Medical; Modeling; Monitor; Motion; Motivation; Motor; Motor Skills; Movement; Neuronal Plasticity; Occupational; Outcome; Parents; Participant; Patient Participation; Patients; Pediatric Hospitals; Performance; Phase; Pilot Projects; Play; Production; Provider; Public Health; Questionnaires; Randomized Controlled Trials; Recovery; Regimen; Rehabilitation therapy; Role playing therapy; Safety; Secure; Self Care; Small Business Innovation Research Grant; Specialist; Supervision; Support System; System; Technology; Testing; Toy; Training; Trauma; Universities; Upper Extremity; User-Computer Interface; Video Games; Virginia; Visual; base; cohort; commercialization; compliance behavior; constraint induced movement therapy; constraint induced therapy; cost; cost effective; dashboard; data fusion; design; dosage; efficacy study; evidence base; exercise program; experience; haptic feedback; improved; improved outcome; individual patient; individualized medicine; innovation; innovative technologies; kinematics; mixed reality; multisensory; programs; prototype; psychologic; remote monitoring; sensor; skills; standard measure; success; telehealth; therapy adherence; therapy duration; treatment as usual; treatment group; tumor; underserved area; usability; virtual; virtual world

PROJECT SUMMARY/ABSTRACT Introduction: The Motivating Occupational Virtual Experiences In Therapy for kids (MOVE-IT) SBIR Phase II program will support telehealth delivery of intensive rehabilitation for pediatric hemiplegia through smart toy- enabled games that inspire high-dosage, task-directed upper extremity (UE) movements. Although higher- dosage training is almost uniformly associated with better outcomes in UE rehabilitation [1], [2], [3], [4], achieving the repetitions necessary to attain lasting results through neuroplasticity is a formidable challenge. The MOVE- IT system will employ therapy games that combine virtual- and real-world physical elements to provide a turn- key solution suitable for both home and clinical use. MOVE-IT will engage patients in repetitive practice, facilitating an evidence-based approach that integrates proven concepts in constraint-induced movement therapy (CIMT) and other intensive therapy regimes [5]. This innovative solution employs a multi-sensory smart toy, advanced game engine, and low-cost motion tracking to create games that promote sustained adherence. Problem to be Addressed: Pediatric hemiplegia can result from Cerebral Palsy (CP) or acquired brain injury (including pediatric stroke, trauma, tumor, or other disease), and adversely affect motor functions essential to self-care, play, exploratory learning, and other daily activities [6]. Existing systems do not currently support telehealth delivery of the high-dosage, evidence-based therapy required for improvement in UE function. Long-Term Goals: Provide an effective home exercise program supported by remote guidance and monitoring of evidence-based treatment for pediatric hemiplegia. Improve patient participation and adherence to an intensive therapy regimen. Reduce the cost of, and improve access to, state-of-the-art rehabilitation. Provide validated metrics for remotely tracking patient status and progress. Phase I Results: Phase I produced a prototype smart toy, two UE therapy mini-games, human kinematics tracking software, and validated UE motor performance metrics. A pilot study was conducted at the University of Virginia (UVA) Children’s Hospital involving 10 children with hemiplegia. Analysis confirms the primary Phase I hypothesis that MOVE-IT generated metrics have high criterion validity with gold-standard measures of UE motor function. Patient/parent interviews/questionnaires strongly support the technology’s acceptance and usability. Phase II Summary: MOVE-IT Phase II will produce a commercial system including an enhanced smart toy and quest-based game software for sustained engagement over a full course of therapy; demonstrate efficacy; establish safety and usability; and pursue FDA-clearance. Phase II will culminate in a rater-blinded randomized, controlled trial to investigate efficacy in home use by children with hemiplegia, as measured by change in gold- standard measures of UE function for a cohort using MOVE-IT compared to a usual care treatment (UCT) group. Commercial Opportunity: High likelihood of commercialization is supported by Barron Associates’ past successes in development, clinical trials, FDA-clearance, and marketing of innovative technology for UE therapy.

项目摘要/摘要 简介：儿童治疗（Move-IT）SBIR II期的激励人造虚拟经历 计划将支持通过智能玩具远程医疗提供小儿偏瘫的密集康复 - 启用了激发高剂量，任务指导的上肢（UE）运动的游戏。虽然更高 - 剂量训练几乎与UE康复中更好的结果相关[1]，[2]，[3]，[4]，实现 通过神经可塑性获得持久结果所必需的重复是一个巨大的挑战。移动 - IT系统将采用结合虚拟和现实世界中物理元素的治疗游戏，以提供转向 关键解决方案适合家庭和临床使用。移动 - 它将让患者参与重复的实践， 促进基于证据的方法，该方法将证明概念纳入约束诱导的运动 治疗（CIMT）和其他强化治疗方案[5]。这种创新的解决方案采用了多感觉智能 玩具，高级游戏引擎和低成本运动跟踪，以创建促进持续依从性的游戏。 要解决的问题：小儿偏瘫可能是由脑瘫（CP）或获得的脑损伤引起的 （包括小儿中风，创伤，肿瘤或其他疾病），并对运动功能产生不利影响 自我护理，游戏，探索者学习和其他日常活动[6]。现有系统当前不支持 改善UE功能所需的高剂量，循证疗法的远程医疗提供。 长期目标：提供有效的家庭锻炼计划，由远程指导和监视支持 小儿偏瘫的循证治疗。改善患者的参与并遵守 强化治疗方案。降低最先进的康复成本并提高获得的成本。提供 经过验证的指标，用于远程跟踪患者状况和进度。 第一阶段结果：我生产了一个原型智能玩具，两个UE治疗迷你游戏，人类运动学 跟踪软件，并验证了UE电动机性能指标。在大学进行了一项试点研究 弗吉尼亚（UVA）儿童医院，涉及10个偏瘫儿童。分析证实了第一阶段 Move-IT产生的指标具有高标准有效性的假设，而UE电动机的金标准测量值 功能。患者/家长访谈/问卷强烈支持该技术的接受度和可用性。 第二阶段摘要：Move-It II阶段将产生一个商业系统，包括增强的智能玩具和 基于Quest的游戏软件，可在整个治疗过程中持续参与；证明效率； 建立安全性和可用性；并追求FDA清理。第二阶段将在分数随机分配中达到高潮， 对照试验，以研究偏瘫儿童的家庭使用效率，这是通过金的变化来衡量的 与常规护理治疗（UCT）组相比，使用Move-IT的UE功能的标准度量量度。 商业机会：Barron Associates的过去支持商业化的可能性很高 开发，临床试验，FDA清除和UE疗法创新技术的营销方面取得了成功。