Center for Translational Research on Aging

老龄化转化研究中心

• 批准号: 10263954
• 负责人: BRADLEY JOHN WILLCOX
• 金额: $ 236.96万
• 依托单位: KUAKINI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-10 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10263954
• 关键词: Advisory Committees; Aging; Asia; Basic Science; Bioinformatics; Biological; Biological Sciences; Biology of Aging; Biostatistics Core; Burn injury; Cardiovascular Diseases; Cells; Center for Translational Science Activities; Centers of Research Excellence; Clinical; Clinical Research; Clinical Sciences; Collaborations; Committee Members; Dementia; Disease; Doctor of Medicine; Doctor of Philosophy; Epidemiology; Faculty; Fostering; Funding; Future; Genetic; Genomics; Geriatrics; Goals; Grant; Hawaii; Heart; Human; Interdisciplinary Study; Laboratories; Longevity; Longitudinal cohort study; Malignant Neoplasms; Medical center; Mentors; Molecular; Mus; Phase; Phenotype; Pilot Projects; Principal Investigator; Process; Research; Research Infrastructure; Research Personnel; Running; Scientist; Senior Scientist; Specimen; System; Therapeutic; Translational Research; Translations; United States National Institutes of Health; Universities; Visit; Work; age related; base; biobank; career; career development; disability; experience; genome sciences; healthspan; healthy aging; improved; innovation; medical schools; meetings; member; mid-career faculty; multidisciplinary; novel; offspring; peer; peer coaching; professor; programs; recruit; research and development; residence; success; visiting scholar

ABSTRACT Kuakini Medical Center (Kuakini) proposes to develop a multidisciplinary Hawai'i-based Center of Biomedical Research Excellence (COBRE) for translational research on aging. This Center will draw on the most promising junior investigators from across the state with cross-institutional and interdisciplinary collaborative efforts between Kuakini, the University of Hawaii John A. Burns School of Medicine (JABSOM), and major academic research centers and medical centers. It will cross institutional borders to promote research aimed at improving human healthy lifespan (healthspan) and ameliorating major age-related diseases, including cardiovascular diseases, cancer and dementia, in people of Hawaii, the U.S. mainland and around the world. The Center will build upon the strengths of Kuakini's five-decade track record of NIH-funded research, its 420,000-specimen biorepository, and its existing strengths in aging research, notably, the 51-year long Kuakini Honolulu Heart Program (Kuakini HHP) and Kuakini Honolulu-Asia Aging Study (Kuakini HAAS), and Kuakini HHP Offspring Study. This will advance translational aging research and foster meaningful solutions toward the disease and disability associated with the aging process. We will pursue this long-term goal via the following specific aims:  Specific Aim 1: Create a world class, innovative, interdisciplinary Center for Translational Research on Aging (CTRA) by building on the existing rare and valuable Kuakini Honolulu Heart Program (Kuakini HHP) and its related studies, existing Kuakini HHP Offspring Study, and research infrastructure.  Specific Aim 2 - Advance the genomic, biological and clinical science of aging, and enhance the world class character of our proposed Center, by enlisting accomplished senior scientists to mentor promising Hawaii-based junior investigators in interdisciplinary research and career development.  Specific Aim 3 - Elevate the capacity of our Center by: i) creating a state-of-the-art Clinical and Translational Core, and ii) collaborating with other Centers of Biomedical Research Excellence. The Clinical and Translational Core will expand upon the strong epidemiologic, genomic and clinical work of Kuakini HHP and related studies and the Kuakini HHP Offspring Study; benefit investigators in the State of Hawaii and abroad, and foster translation of basic science and clinical findings into novel applications and therapeutics for healthy aging. COBRE funding will be leveraged with institutional commitments to accelerate the development of research excellence. The Center will collaborate with three other Hawaii-based COBREs, the COBRE Mouse Phenotyping Core, and the INBRE-funded Bioinformatics and Biostatistics Core at the University of Hawaii.

抽象的 Kuakini医疗中心（Kuakini）提出的提案，以开发一个基于夏威夷的多学科生物医学中心 研究卓越研究（COBRE），用于翻译衰老研究。这个中心将最大程度地利用 来自全州的有前途的初级调查员，通过跨机构和跨学科合作 Kuakini，夏威夷大学John A. Burns医学院（JABSOM）和Major之间的努力 学术研究中心和医疗中心。它将跨越机构边界，以促进针对的研究 改善人类健康的寿命（HealthSpan）和改善与年龄有关的主要疾病，包括 夏威夷，美国大陆及世界各地的心血管疾病，癌症和痴呆症。 该中心将基于Kuakini的NIH资助研究的五年历史记录，并以此为基础 420,000特定的生物座席及其在衰老研究中的现有优势，尤其是51岁的Kuakini 檀香山心脏计划（Kuakini HHP）和Kuakini檀香山 - 亚洲老化研究（Kuakini Haas）和Kuakini HHP后代研究。这将推动转化衰老的研究并促进有意义的解决方案 疾病和残疾与衰老过程有关。 我们将通过以下特定目标实现这一长期目标： 特定目标1：创建世界一流，创新，跨学科研究中心 通过建立现有稀有且有价值的Kuakini檀香山心脏计划的衰老（CTRA） （Kuakini HHP）及其相关研究，现有的Kuakini HHP后代研究和研究 基础设施。 具体目标2-推进衰老的基因组，生物学和临床科学，并增强世界 我们提议的中心的班级特征，通过邀请有成就的高级科学家在心理上承诺 位于夏威夷的跨学科研究和职业发展的初级研究人员。 特定目标3-通过以下方式提高我们中心的能力：i）创建最先进的临床和 转化核心和II）与其他生物医学研究中心合作。 临床和转化核心将扩展在强大的流行病学，基因组和临床工作上 Kuakini HHP和相关研究以及Kuakini HHP后代研究；福利状态的调查员 夏威夷和国外，以及将基础科学和临床发现的促进转化为新的应用， 健康衰老的治疗剂。毛绒资金将通过机构承诺来加速加速。 卓越研究的发展。该中心将与其他三个位于夏威夷的Cobres合作， 小鼠表型核心以及inbre资助的生物信息学和生物统计学核心 夏威夷大学。