Core 1: Biospecimen/Pathology

核心 1：生物样本/病理学

基本信息

批准号：
10263345
负责人：
Shannon Jones McCall
金额：
$ 10.02万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-14 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10263345
关键词：
Accreditation African American American Award Bioinformatics Biological Biomedical Research Biopsy Blood Blood specimen Cancer Center Support Grant Cancer Model Catchment Area Cell Culture Techniques Clinical Clinical Research Collection Colon Carcinoma Communities Community Outreach Consent Cooperative Human Tissue Network Country Data Data Analyses Development Ensure Equipment and supply inventories Ethnic Origin Exposure to Fresh Tissue Funding Future Generations Goals Helicobacter pylori Histology Immunohistochemistry Informed Consent Institutes International KRASG12D Libraries Link Liquid substance Malignant Neoplasms Malignant neoplasm of lung Minority Groups Minority Participation Modeling Molecular Mutate Neoadjuvant Therapy Neoplasm Metastasis Nucleic Acids Participant Pathologist Pathology Patients Pilot Projects Primary Neoplasm Process Protocols documentation Race Research Research Design Research Institute Research Personnel Research Project Grants Resource Sharing Retrospective cohort Sampling Services Societies Specimen Stomach Therapeutic Intervention Tissue Procurements Tissue Sample Tissues Translational Research Trust Underrepresented Minority Underrepresented Populations Update base biobank black patient cancer health disparity career development cohort college community engagement data registry health equity human model improved innovation meetings metabolomics molecular phenotype patient derived xenograft model programs repository sample collection success transcriptome sequencing translational cancer research tumor registry

项目摘要

ABSTRACT – Biospecimen/Pathology Core (Core 1) The Biospecimen/Pathology Core of the Duke Cancer Health Disparities P20 SPORE (DCHD) leverages and is housed in the Duke Cancer Institute’s BioRepository & Precision Pathology Center (BRPC). The BRPC is a Shared Resource of the Duke Cancer Institute and supported in part by the Duke Cancer Center Support Grant (5P30-CA014236-45). This NCI-funded shared service center obtains broad consent from patients for blood and tissue sample donation and procures, processes and banks both liquid and tissue biospecimens, supports Duke’s “living biobank” with the Duke Patient-Derived Xenograft and Primary Tumor Cell Culture Services, and implements bioinformatic and clinical strategies for precise sample and model annotation. For the DCHD, the Core will efficiently provide high-quality tissue, blood and fluid-based biospecimens and processing services to requesting investigators, and continue to adjust practices as researcher needs evolve (Aim 1); support current and future DCHD P20 projects through expansion of existing best practices in tissue procurement, processing, and sample management (Aim 2); and educate the local, regional and national community on the importance of available biospecimens in biomedical research to enhance availability of specimens and data from underrepresented minorities (Aim 3). The Duke BRPC has recently been awarded an NCI UM1 to join the Cooperative Human Tissue Network (CHTN)(www.chtn.org); this network of biorepositories will support deeper cohort generation from across the country. For the proposed Projects, we will provide appropriate lung cancer specimens and associated data from multiple races/ethnicities (Project 1), and stomach biopsies positive for H. pylori from Black patients (Project 2). The needs of future Pilot Projects will be assessed for feasibility; given the BRPC’s existing library, a recent focus on underrepresented minority inclusion, and CHTN participation, a wide range of cancer disparities research should be possible. This Core is fully integrated into the DCHD and is critical for its success.

摘要 – 生物样本/病理学核心（核心 1）杜克癌症健康差异 P20 SPORE (DCHD) 的生物样本/病理学核心利用并位于杜克癌症研究所的生物储存库和精密病理学中心 (BRPC)。杜克癌症研究所的共享资源，并由杜克癌症中心支持拨款提供部分支持 (5P30-CA014236-45) 这个由 NCI 资助的共享服务中心获得了患者的广泛同意，用于血液和药物治疗。组织样本捐赠和采购、处理和储存液体和组织生物样本，支持杜克大学的“活体生物库”以及杜克大学患者来源的异种移植和原代肿瘤细胞培养服务，以及实施精确样本和模型注释的生物信息学和临床策略。 Core 将高效地为以下领域提供高质量的组织、血液和液体生物样本及处理服务：要求研究人员，并根据研究人员需求的变化不断调整实践（目标 1）；和未来的 DCHD P20 项目，通过扩展组织采购、加工、和样本管理（目标 2）；并教育当地、区域和国家社区了解以下方面的重要性：生物医学研究中可用的生物样本，以提高样本和数据的可用性代表性不足的少数群体（目标 3）最近获得了 NCI UM1 加入杜克大学 BRPC 的资格。合作人体组织网络（CHTN）（www.chtn.org）；该生物样本库网络将支持对于拟议的项目，我们将提供适当的来自全国各地的队列生成。来自多个种族/民族的肺癌标本和相关数据（项目 1）以及胃活检黑人患者幽门螺杆菌呈阳性（项目 2）将评估未来试点项目的需求。可行性；考虑到 BRPC 现有的图书馆、最近关注代表性不足的少数群体包容性和 CHTN 参与，广泛的癌症差异研究应该完全融入这一核心。 DCHD 对其成功至关重要。