Longitudinal Trajectories of Physical and Cognitive Function among Persons Aging with HIV

艾滋病毒感染者的身体和认知功能的纵向轨迹

• 批准号: 10263350
• 负责人: Mary Clare Masters
• 金额: $ 15.95万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10263350
• 关键词: AIDS clinical trial group; Adult; Aging; Antidiabetic Drugs; Attenuated; Award; Caring; Clinical; Clinical Investigator; Clinical Trials; Cognition; Cohort Studies; Data; Development; Development Plans; Diabetes Mellitus; Elderly; Exercise; Exhibits; Female; Funding; Future; Gait speed; General Population; Glycosylated hemoglobin A; HIV; HIV Infections; Hand Strength; Hyperglycemia; Impaired cognition; Impairment; Incidence; Individual; Intervention; Investigation; Link; Longitudinal Studies; Measurement; Metformin; Mission; Morbidity - disease rate; Nature; Neurocognitive Deficit; Observational Study; Outcome; Participant; Persons; Pharmaceutical Preparations; Phenotype; Physical Function; Physical Performance; Physical activity; Population; Prediabetes syndrome; Proxy; Research; Research Personnel; Risk; The Multicenter AIDS Cohort Study; United States National Institutes of Health; Viral; Viremia; Woman; Women' s Interagency HIV Study; age related; anti aging; antiretroviral therapy; base; blood glucose regulation; career; cognitive function; cognitive performance; cohort; experience; frailty; functional decline; functional disability; functional status; glucose metabolism; immune function; improved; insight; interest; male; men; mortality; preservation; prevent; programs; prospective

PROJECT SUMMARY AND ABSTRACT Older persons with HIV (PWH) experience high rates of cognitive impairment and accelerated declines in function compared to the general population. These functional status declines have been associated with significant morbidity and mortality in among PWH. Among the elderly in the general y population, longitudinal dynamic relationships between physical and cognitive function have been identified. In PWH, cross-sectional associations between impaired cognition and physical function have been previously noted, but longitudinal trajectories of cognitive and physical function and how they are related have not been evaluated. Metformin has shown promise as a senolytic agent. Clinical trials are underway to investigate use of metformin in preventing age-related declines in among elderly adults without HIV. This proposal will investigate the longitudinal relationship between cognitive and physical function in PWH and assess the potential impact of metformin use on these trajectories. The proposed study will utilize data available from three large prospective, observational cohorts of men and women with or at risk for HIV. This investigation will be the first to comprehensively examine longitudinal associations between cognitive and physical function in a large group of PWH and assess the impact of metformin therapy on these outcomes among PWH. Our findings will inform the focus and ideal timing of interventions such as a formal interventional clinical trial of metformin use to prevent cognitive and physical function declines among older PWH. Moreover, this proposal aligns with the GEMSSTAR program’s mission to support a young investigator seeking to bridge aging and HIV research to improve care for older PWH.

项目摘要和摘要 艾滋病毒（PWH）的老年人经历了高度的认知障碍率，并加速下降 与一般人群相比，功能。这些功能状态下降与 PWH中的显着发病率和死亡率。在一般人口中，纵向 已经确定了身体和认知功能之间的动态关系。在PWH中，横截面 以前已经注意到认知和身体机能受损之间的关联，但纵向 尚未评估认知和身体功能以及如何相关的轨迹。二甲双胍具有 显示为鼻溶剂的承诺。正在进行临床试验以调查二甲双胍预防的使用 与年龄相关的没有艾滋病毒的老年人的下降。该提议将调查纵向 PWH中认知和身体功能之间的关系并评估二甲双胍使用的潜在影响 在这些轨迹上。拟议的研究将利用来自三个大型前瞻性观测的可用数据 有艾滋病毒风险或有风险的男性和女人的同龄人。这项投资将是第一个全面研究的投资 在大量PWH中认知和身体机能之间的纵向关联并评估影响 PWH中这些结果的二甲双胍疗法。我们的发现将为重点和理想的时机提供信息 诸如二甲双胍用于预防认知和物理的正式介入临床试验之类的干预措施 功能在较旧的PWH中下降。此外，该提案与Gemsstar计划的使命一致 支持一名年轻的研究人员，寻求桥接衰老和艾滋病毒研究，以改善对老年PWH的护理。