QMRA IV- Quantitative Microbial Risk Assessment Interdisciplinary Vehicle: Addressing Emerging Global Health Risks

QMRA IV-定量微生物风险评估跨学科工具：应对新出现的全球健康风险

• 批准号: 10263889
• 负责人: Jade Mitchell
• 金额: $ 46.11万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-16 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10263889
• 关键词: Address; Air; Behavioral; Biological Process; Biology; Communicable Diseases; Communities; Complex; Data; Data Set; Decision Making; Decontamination; Development; Discipline; Disease; Education; Emergency response; Engineering; Enrollment; Environment; Environmental Health; Epidemiologist; Equilibrium; Etiology; Evaluation; Exposure to; Food; Funding; Future; Goals; Health; Health Policy; Health Professional; Human; Industrial Health; Infection; Infectious Agent; Intervention; Lead; Learning; Mathematics; Measures; Mentors; Methodology; Modeling; Outcome; Participant; Population; Positioning Attribute; Prevention strategy; Probability; Process; Public Health; Research; Research Personnel; Rest; Risk; Risk Assessment; Risk Management; Science; Scientist; Soil; Specialist; Surface; System; Training; Translational Research; Trust; Uncertainty; United States National Institutes of Health; Water; Work; World Health Organization; base; biomedical scientist; career; computational platform; computerized tools; evidence base; first responder; foodborne illness; global health; improved; knowledge integration; learning materials; mathematical methods; medical countermeasure; member; microbial; mid-career faculty; multidisciplinary; outreach; pathogenic microbe; preventive intervention; programs; public health emergency; risk minimization; senior faculty; skills; statistics; tool; training opportunity; waterborne illness

Project Summary/Abstract Quantitative microbial risk assessment (QMRA) is a research domain that addresses exposures to microbial pathogens and infectious disease processes in order to characterize human health effects. It has become a well-established framework for predictive and retrospective evaluations of health risks. QMRA is a translational science requiring integration of knowledge from mathematics, statistics, biology, engineering, and public health. Though complex, QMRA is highly useful for addressing societal problems encountered within the multidisciplinary biomedical community - public health, emergency response, environmental control measures, decontamination, industrial hygiene and medical countermeasures. Exposure to microbial agents of disease and subsequent development of infection are dynamic processes associated with substantial variability and uncertainty across the population, which must also be communicated in order to effectively manage risk. Since risk science is inherently interdisciplinary, few programs in the contributing disciplines offer courses and training in QMRA. Though training, models and tools have increased as the result of our preliminary work, barriers to full participation across the biomedical community still exists especially needs in mentoring and outreach. Our long term goals are to increase the capability for biomedical and behavioral scientists: (i) to incorporate and contribute to microbial risk assessments related to their research; and (ii) to increase their ability to lead and contribute to diverse, interdisciplinary team science projects related to microbial risks. The objective of this project is to provide the biomedical community with comprehensive training in microbial risk sciences, evidence-based mentoring approaches to support inclusion and participation of scientists from diverse backgrounds and a data/computational platform to facilitate deeper learning and the QMRA practice. The proposed project builds upon several, successful, ten-day courses offered through the NIH funded QMRAIII program (2014 to 2018) and previous one week-long, intensive courses conducted through the Center for Advancing Microbial Risk Assessment) from 2006 to 2011. Each year, there were significantly more applicants than allowable enrollment; and mid-career and senior faculty members were generally excluded to prioritize early career researchers. Our evaluations and assessments support our model of practice for reaching learning objectives. However, the balance of contributions across the biomedical community would be greatly enhanced through sustained mentoring and outreach opportunities which are complementary to the course as well as an online platform for future trainees and educators.

项目摘要/摘要 定量微生物风险评估（QMRA）是一个研究领域，可解决微生物的暴露 病原体和传染病过程，以表征人类健康的影响。它已成为一个 完善的框架，用于对健康风险进行预测和回顾性评估。 QMRA是翻译 科学需要从数学，统计，生物学，工程和公众中融合知识 健康。 QMRA虽然很复杂，但对于解决内部遇到的社会问题非常有用 多学科生物医学界 - 公共卫生，应急响应，环境控制措施， 去污，工业卫生和医学对策。暴露于疾病的微生物剂 感染的随后发展是与实质性变异性相关的动态过程 整个人群的不确定性也必须进行传达才能有效地管理风险。自从 风险科学本质上是跨学科的，在贡献学科中很少有课程提供课程和 QMRA培训。尽管培训，模型和工具因我们的初步工作而增加了 在生物医学界充分参与的障碍仍然存在指导和 外展。我们的长期目标是提高生物医学和行为科学家的能力：（i） 纳入并促进与其研究相关的微生物风险评估； （ii）增加他们的 能够领导和促进与微生物风险有关的多样化，跨学科的团队科学项目。这 该项目的目的是为生物医学社区提供微生物风险的全面培训 科学，基于证据的指导方法，以支持和参与科学家的参与 不同的背景和数据/计算平台，以促进更深入的学习和QMRA实践。 拟议的项目建立在NIH资助的几项成功的十天成功的课程基础上 QMRAIII计划（2014年至2018年）和前一周的密集课程通过 从2006年到2011年，用于推进微生物风险评估的中心。每年，都有更多的 申请人比允许的入学人数；职业生涯和高级教职员工通常被排除在外 优先考虑早期职业研究人员。我们的评估和评估支持我们的实践模型 达到学习目标。但是，整个生物医学界的贡献平衡将是 通过持续的指导和外展机会得到了极大的增强，这些机会是互补的 课程以及未来学员和教育工作者的在线平台。