Core D: Neuropathology Core

核心 D：神经病理学核心

• 批准号: 10264626
• 负责人: Mohammad Haeri
• 金额: $ 25.8万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264626
• 关键词: Address; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Autopsy; Awareness; Biological Markers; Biopsy; Brain; Cell Line; Cells; Clinical; Consent; Consultations; DNA sequencing; Diagnostic; Doctor of Philosophy; Goals; Guidelines; Image; Infrastructure; Institution; Kansas; Leadership; Libraries; Mentors; Metabolism; Mission; Mitochondrial DNA; Molecular; Molecular Profiling; National Institute on Aging; Neurodegenerative Disorders; Pathology; Physicians; Protocols documentation; Reporting; Research; Research Activity; Research Personnel; Running; Scanning; Science; Scientist; Services; Slide; Tissues; Training; Training Activity; Training and Education; Universities; biobank; cohort; education research; endophenotype; induced pluripotent stem cell; neuropathology; operation; outreach; prevent; programs; ranpirnase; recruit; research and development; symposium

ABSTRACT: NEUROPATHOLOGY CORE The University of Kansas Alzheimer's Disease Research Center (KU ADRC) Neuropathology Core assesses Clinical Cohort decedent brains. It applies current National Institute on Aging–Alzheimer's Association diagnostic guidelines and provides this information to the National Alzheimer's Coordinating Center (NACC). The Core maintains autopsy tissue in its Brain Bank, provides consultation services to requesting investigators, and performs specialized analyses to meet specific investigator needs. The Core supports additional Center operations including the Clinical Core's autopsy consent and the Biomarker Core's mitochondrial DNA (mtDNA) sequencing programs. It obtains dural biopsies used to create induced pluripotent stem cell (iPSC) lines. The Neuropathology Core holds regular clinicopathologic conferences that educate Center stakeholders on the pathology of neurodegenerative diseases, and in conjunction with the Center's Research Education Component (REC) supports more intensive formal neuropathology training. By promoting KU ADRC research during the 2021-26 cycle, the Neuropathology Core advances the KU ADRC mission to advance Alzheimer's disease and related dementias (ADRD) science including science related to our scientific theme of metabolism. The Neuropathology Core will accomplish its goals by focusing on a defined set of specific aims that include: (1) Running the KU ADRC autopsy program; (2) Running the KU ADRC Brain Bank program; (3) Promoting neuropathology training, development, and research activities.

摘要：神经病理学核心 堪萨斯大学阿尔茨海默氏病研究中心（KU ADRC）神经病理学核心 评估临床队列的决策大脑。 协会诊断准则，并为国家阿尔茨海默氏症的核心提供信息 中央（NACC）。 请求研究人员，并执行专门的分析以满足特定的研究者需求。 支持Aditional Center操作运营临床核心的尸检和生物标志物Core Core的核心 线粒体DNA（mtDNA）测序程序。 干细胞（IPSC）线。 中央利益相关者对神经退行性疾病的病理，并与中心的结合 研究教育部分（REC）支持更强化的正式神经病理学培训。 通过在2021-26周期中促进KU ADRC研究，神经病理学核心促进了KU ADRC的使命是推进阿尔茨海默氏病和相关痴呆症（ADRD）科学，包括科学 与我们的科学主题相关的神经病理学核心将通过关注来实现其目标 在一组定义的特定目的上，包括：（1）运行KU ADRC尸检程序；（2）运行KU ADRC大脑银行计划；（3）促进神经病理学培训，开发和研究活动。