Core D: Neuropathology Core

核心 D：神经病理学核心

• 批准号: 10264291
• 负责人: Ann C. McKee
• 金额: $ 29.96万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10264291
• 关键词: Address; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid beta-Protein; Argyrophilic Grain Disease; Astrocytes; Biochemical; Biological Assay; Biological Markers; Boston; Brain; Brain Concussion; Cerebral Amyloid Angiopathy; Clinic; Clinical; Collaborations; Communities; DNA; Data; Diagnosis; Diagnostic; Digital Libraries; Doctor of Philosophy; Environmental Risk Factor; Epitopes; Evaluation; Exposure to; Family member; Fostering; Foundations; Framingham Heart Study; Frontotemporal Lobar Degenerations; Funding; Goals; Image; Infrastructure; Investigation; Knowledge; Leadership; Lewy Body Disease; Long-Term Effects; Measures; Methods; Microvascular Dysfunction; Molecular Profiling; Myelin; Nerve Degeneration; Nervous System Trauma; Outcome; Pathology; Phenotype; Prion Diseases; Progressive Supranuclear Palsy; RNA; Research; Research Personnel; Research Training; Resources; Risk Factors; Role; Scientist; Slide; System; Tauopathies; Tissues; Training; Trauma; United States National Institutes of Health; Universities; Work; abeta deposition; age related; alpha synuclein; biomarker development; chronic traumatic encephalopathy; contact sports; corticobasal degeneration; cytokine; data management; digital; education research; genetic profiling; genetic risk factor; head impact; high resolution imaging; hippocampal sclerosis; improved; innovation; international center; member; military service; neuroinflammation; neuropathology; next generation; novel marker; outreach; phenotypic data; programs; protein TDP-43; recruit; skills; statistics; tau Proteins; white matter

The Boston University Alzheimer’s Disease Research Center (BU ADRC) Neuropathology Core (NC) facilitates AD/ADRD research, conducts cutting-edge multi-ADRC AD/ADRD research and provides national leadership in AD/ADRD neuropathology. We facilitate AD/ADRD research by performing state-of-the-art diagnostic neuropathological evaluation on all brain donors, sharing well-characterized CNS tissue and biospecimens with qualified investigators; providing deep neuropathological phenotyping to foster innovative collaborations; and training the next generation of AD/ADRD neuropathologists and researchers. In addition, the NC conducts cutting-edge multi-ADRC research on AD/ADRD. The BU ADRC NC’s transformational research on post-traumatic neurodegeneration has changed scientific understanding of neurotrauma as a risk factor for AD/ADRD, including chronic traumatic encephalopathy (CTE). The NC has also shown that exposure to repetitive head impacts (RHI) alters the deposition of beta amyloid, alpha-synuclein, and TDP-43. Currently, the NC is collaborating with multiple ADRCs and centers (UCSF, Mayo Clinic, Mount Sinai, MGH, UT San Antonio) to continue this ground- breaking research. In addition, the NC provides national leadership by leading two major multi- ADRC NIH-funded programs on AD/ADRD. The NC will build on this strong record of accomplishment and leadership to support innovative multi-ADRC AD/ADRD research in 3 domains that support National Alzheimer’s Project Act (NAPA) milestones for AD/ADRD research: Understanding the contribution of RHI/TBI exposure to AD/ADRD; Understanding the role of age-related and trauma-related microvascular disease and white matter degeneration to AD/ADRD; Improving the neuropathological diagnostic and nosologic criteria for frontotemporal lobar degeneration-tau (FTLD-tau). The NC also works closely with the Framingham Heart Study by directing all brain banking and neuropathological analyses. In partnership with the Concussion Legacy Foundation global brain bank initiative, the BU ADC NC is committed to advancing multi-center international research. Throughout all its aims, the NC will work with the Clinical Core and Data Management and Statistics Core to enhance clinicopathological correlation in AD/ADRD, the Biomarker Core to develop novel biomarkers for AD/ADRD, the Genetics and Molecular Profiling Core to define genetic risk factors for AD/ADRD, the Research Education Component (REC) to engage trainees in scientific investigations and build skills in AD/ADRD research and the Outreach, Recruitment and Engagement Core (ORE) to educate the greater Boston community about the value of brain donation.

波士顿大学阿尔茨海默氏病研究中心（BU ADRC）神经病理核心 （NC）促进AD/ADRD研究，进行尖端的多ADRC AD/ADRD研究和 提供广告/ADRD神经病理学的国家领导 对所有大脑供体进行最先进的神经病理学评估，共享 具有合格研究者的特征性的中枢神经系统组织和生物测量 神经病理表型培养创新的合作； AD/AD/ADROPALOLOLAL和研究人员的产生。 关于广告/AD/AD/ADRD的尖端多ADRC研究。 关于创伤后神经退行性变化，改变了对神经曲霉的科学理解 AD/AD/AD/AD/AD/AD/的风险因素（CTE）也有NC。 表明暴露于重复的头部影响（RHI）改变了β-淀粉样蛋白的沉积， alpha-synuclein和TDP-43。 中心（UCSF，梅奥诊所，西奈山，MGH，UT San Antonio） 北卡罗来纳州的研究。 ADRC NIH资助的AD/ADRD计划。 成就和领导才能支持创新的多ADRC AD/ADRD研究 支持全国阿尔茨海默氏症项目法案（NAPA）的域名 研究：了解RHI/TBI对AD/ADRD的贡献； 与年龄相关和创伤有关的微血管疾病以及白质变性的作用 AD/ADRD； Lobar Demeneration-Tau（FTLD-TAU）也与Framingham心脏近似 通过与所有与神经病理学分析进行研究。 BU ADC NC致力于脑震荡遗产基金会全球脑库计划 在所有目标中，都在进行多中心的国际研究。 临床核心和数据管理和统计核心，以增强临床病理学 AD/ADRD的相关性是开发AD/ADRD新型生物标志物的生物标志物核心 遗传学和分子分析核心以定义AD/AD/ADRD的遗传危险因素，研究 教育部分（REC）让学员参与科学研究并建立技能 AD/ADRD研究以及宣传，招聘和英语核心（矿石）教育 大波士顿社区关于大脑捐赠的价值。