Extending Sleep to Improve Glycemic Control in Pediatric Type 1 Diabetes

延长睡眠时间以改善儿童 1 型糖尿病的血糖控制

• 批准号: 10263142
• 负责人: Michelle M Perfect
• 金额: $ 39.72万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-12 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10263142
• 关键词: Address; Adherence; Adolescence; Adolescent; Adult; Affect; Age; American; Attention; Beds; Behavior Therapy; Behavioral; Biological; Biological Markers; Blindness; Blood Glucose; Caring; Centers for Disease Control and Prevention (U.S.); Child; Childhood; Clinic; Clinical; Data; Development; Diabetes Mellitus; Diet; Disease; Disease Outcome; Disease Progression; Distress; Emotional; Evaluation; Glucose; Glycemic Index; Glycosylated hemoglobin A; Gold; Healthy People 2020; Hydrocortisone; Individual; Insulin; Insulin-Dependent Diabetes Mellitus; Intervention; Knowledge; Lead; Length; Link; Mediating; Mental Depression; Modification; Monitor; Morbidity - disease rate; Organ; Outcome; Pathway interactions; Patients; Pharmaceutical Preparations; Physical activity; Physiological; Positioning Attribute; Quality of life; Randomized; Recommendation; Reporting; Research; Research Project Grants; Role; Schedule; Schools; Sleep; Sleep Deprivation; Sleep disturbances; Slow-Wave Sleep; Technology; Telephone; Testing; Time; Translational Research; Youth; attentional control; base; behavioral outcome; blood glucose regulation; care burden; clinical care; clinical practice; cost effective; diabetes management; diabetes self-management; disorder control; emotional functioning; experience; experimental study; follow-up; glucose monitor; glycemic control; heart rate variability; improved; improved outcome; innovation; mortality; neurobehavioral; novel strategies; response; sleep behavior; sleep regulation; social

It is known that sleep disturbances in healthy youth have negative effects on neurobehavioral functioning. Further, data support that individuals with diabetes have more sleep disturbances and compromised neurobehavioral functioning than individuals without diabetes. Unfortunately, sleep is not routinely addressed in standard clinical care for youth with diabetes. An experimental study is needed to verify the direct impact of sleep duration on glycemic control and neurobehavioral functioning in youth with type 1 diabetes. Therefore, our primary study aims are to (1) Test if lengthening sleep improves glycemic control and in youth with T1DM; (2) Assess if “booster” sessions can contribute to sustained sleep length; and (3) Assess if “booster” sessions can lead to statistically and clinically meaningful changes in HbA1c, the gold standard of glucose control. In the proposed randomized study, up to 175 youth (ages 10 through 16) with T1DM will be assigned to a Sleep Extension or a Control condition. The Sleep Extension lengthens youth's time in bed to allow for a healthy sleep duration, whereas the control condition does not impose a prescribed sleep schedule; it controls for time and attention. We will test the impact of sleep extension on key indices of glycemic control (average glucose levels and % time in range) and secondary benefits (e.g., quality of life, diabetes-related distress, and social-emotional functioning); examine the mediating role of adherence, and explore physiological pathways of effect (e.g., heart rate variability (HRV), cortisol levels) Once our aims are achieved and a causal link is established, the proposed Sleep Extension intervention will advance knowledge about the role of sleep in diabetes management and provide a beneficial intervention to help youth with T1DM.

众所周知，健康青年的睡眠障碍对 神经行为功能。此外，数据支持糖尿病患者有更多的数据 与没有的人相比 糖尿病。不幸的是，对于青年的标准临床护理，没有常规地解决睡眠 糖尿病。需要一项实验研究来验证睡眠时间对 1型糖尿病青年的血糖控制和神经行为功能。因此，我们的 主要研究目的是（1）测试是否加长睡眠会改善血糖控制和青年 使用T1DM； （2）评估“助推器”课程是否可以导致持续的睡眠时间； （3） 评估“助推器”课程是否可以导致统计和临床上有意义的HBA1C变化， 葡萄糖控制的金标准。在拟议的随机研究中，多达175名青年（年龄） 10至16）使用T1DM分配到睡眠延长或控制条件。这 睡眠延长会延长青年在床上的时间，以允许健康的睡眠时间，而 控制条件不会施加规定的睡眠时间表；它控制时间和注意力。 我们将测试睡眠扩展对血糖控制关键指标的影响（平均葡萄糖 水平和范围的时间％）和次要福利（例如，生活质量，与糖尿病有关 困扰和社会情感功能）；检查依从性的中介作用，并 探索效果的物理途径（例如，心率变异性（HRV），皮质醇水平）一次 我们的目标是实现的，并建立了因果关系，拟议的睡眠扩展 干预将促进有关睡眠在糖尿病管理中的作用的知识， 提供有益的干预措施，以帮助青年患有T1DM。

项目成果

The Development of a Clinically Relevant Sleep Modification Protocol for Youth with Type 1 Diabetes.

针对患有 1 型糖尿病的青少年制定临床相关的睡眠修改方案。

• DOI: 10.1037/cpp0000145
• 发表时间: 2016
• 期刊: Clinical practice in pediatric psychology
• 影响因子: 1.1
• 作者: Perfect,MichelleM;Beebe,Dean;Levine-Donnerstein,Deborah;Frye,SaraS;Bluez,GraiP;Quan,StuartF
• 通讯作者: Quan,StuartF