An Administrative Research Supplement to Support Diversity for Parent Grant Extending Sleep to Improve Glycemia in Pediatric Type 1 Diabetes

支持家长多样性的行政研究补充资助延长睡眠时间以改善儿童 1 型糖尿病的血糖

• 批准号: 9795677
• 负责人: Michelle M Perfect
• 金额: $ 1.45万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-12 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9795677
• 关键词: Address; Adherence; Adolescence; Adolescent; Adult; Affect; Age; American; Attention; Beds; Behavioral; Biological; Blindness; Blood Glucose; Centers for Disease Control and Prevention (U.S.); Child; Childhood; Clinic; Clinical; Data; Diabetes Mellitus; Diet; Disease; Disease Outcome; Disease Progression; Distress; Emotional; Evaluation; Glucose; Glycemic Index; Glycosylated hemoglobin A; Gold; Healthy People 2020; Hydrocortisone; Insulin; Insulin-Dependent Diabetes Mellitus; Intervention; Knowledge; Lead; Length; Link; Mediating; Mental Depression; Metabolic; Modification; Monitor; Morbidity - disease rate; Organ; Outcome; Pathway interactions; Patients; Pharmaceutical Preparations; Physical activity; Physiological; Positioning Attribute; Quality of life; Randomized; Recommendation; Reporting; Research; Role; Schedule; Schools; Self Management; Sleep; Sleep Deprivation; Slow-Wave Sleep; Technology; Telephone; Testing; Time; Translational Research; Youth; attentional control; base; behavioral outcome; blood glucose regulation; care burden; clinical care; clinical practice; diabetes management; disorder control; experience; experimental study; follow-up; glucose monitor; glycemic control; heart rate variability; improved; innovation; mortality; neurobehavioral; parent grant; psychosocial; response; sleep behavior; sleep regulation; social; stress symptom

Extending Sleep to Improve Glycemia in Pediatric Type 1 Diabetes RDK110528-A Project Abstract Data have increasingly supported the association of sleep and metabolic functioning. We previously found that various sleep parameters are associated with glucose control and psychosocial functioning. Unfortunately, sleep is not routinely addressed in standard clinical care for youth with type 1 diabetes mellitus (T1DM). An experimental study is needed to verify the direct impact of sleep duration on glycemic control and neurobehavioral functioning in youth with type 1 diabetes. Therefore, our primary study aims are to (1) Test if lengthening sleep improves glycemic control and in youth with T1DM; (2) Assess if “booster” sessions can contribute to sustained sleep length; and (3) Assess if “booster” sessions can lead to statistically and clinically meaningful changes in HbA1c, the gold standard of glucose control. In the proposed randomized study, up to 175 youth (ages 10 through 17) with T1DM will be assigned to a Sleep Extension or a Control condition. The Sleep Extension lengthens youth's time in bed to allow for a healthy sleep duration, whereas the control condition does not impose a prescribed sleep schedule; it controls for time and attention. We will test the impact of sleep extension on key indices of glycemic control (average glucose levels and % time in range) and secondary benefits (e.g., quality of life, diabetes-related distress, and social-emotional functioning, traumatic stress symptoms); examine the mediating role of adherence, and explore physiological pathways of effect (e.g., heart rate variability (HRV), cortisol levels) Once our aims are achieved and a causal link is established, the proposed Sleep Extension intervention will advance knowledge about the role of sleep in diabetes management and provide a beneficial intervention to help youth with T1DM.

延长睡眠以改善小儿1型糖尿病的血糖 RDK110528-A 项目摘要 数据增加了睡眠和代谢功能的关联。我们 以前发现各种睡眠参数与葡萄糖控制和 社会心理功能。不幸的是，在标准临床中未常规地解决睡眠 护理1型糖尿病（T1DM）的青年。需要一项实验研究以验证 睡眠持续时间对青年人的血糖控制和神经行为功能的直接影响 与1型糖尿病。因此，我们的主要研究目的是（1）测试是否延长睡眠 改善血糖控制和T1DM青年； （2）评估“助推器”会议是否可以 有助于持续的睡眠长度； （3）评估“助推器”会议是否可以从统计上导致 HBA1C（葡萄糖控制的黄金标准）的临床意义变化。在 拟议的随机研究，将分配多达175名青年（10至17岁）T1DM 到睡眠延伸或控制条件。睡眠延长延长了青年在床上的时间 为了允许健康的睡眠持续时间，而控制条件不施加 处方睡眠时间表；它控制时间和注意力。我们将测试睡眠的影响 扩展血糖控制的关键指标（平均葡萄糖水平和范围内的百分比）和 次要好处（例如，生活质量，与糖尿病有关的困扰和社会情感 功能，创伤性压力症状）；检查依从性的中介作用，并探索 效果的物理途径（例如，心率变异性（HRV），皮质醇水平） 实现目标并建立因果关系，拟议的睡眠延长干预 将促进有关睡眠在糖尿病管理中的作用的知识，并提供 有益的干预措施，以帮助青年患有T1DM。