Validation of the Addictions Neuroclinical Assessment Among Diverse Individuals with Alcohol Use Disorder

不同酒精使用障碍患者成瘾神经临床评估的验证

• 批准号: 10262942
• 负责人: Elena Rachel Stein
• 金额: $ 3.39万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-14 至 2022-07-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10262942
• 关键词: Address; Adopted; Adoption; Alcohol consumption; Alcohols; Assessment tool; Basic Science; Behavior; Behavioral; Caring; Clinical; Cognitive; Data; Data Analyses; Diagnosis; Emotional; Equation; Executive Dysfunction; Foundations; Future; Genomics; Goals; Heterogeneity; Hour; Individual; Lead; Life; Literature; Longitudinal Studies; Measurement; Measures; Mental disorders; Methodology; Methods; Modeling; Movement; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Neurobiology; Neuropsychology; Neurosciences; Outcome; Patient Self-Report; Patients; Phenotype; Process; Reporting; Research; Research Domain Criteria; Research Personnel; STEM research; Sampling; Science; Severities; Sex Differences; Standardization; Structure; Testing; Time; Validation; Work; addiction; alcohol abuse therapy; alcohol behavior; alcohol testing; alcohol use disorder; base; behavior change; clinically relevant; drinking; drinking behavior; emotional functioning; evidence base; executive function; follow-up; functional improvement; improved; incentive salience; indexing; neural circuit; neurobiological mechanism; neuroimaging; precision medicine; psychologic; racial and ethnic; recruit; research study; sex; socioeconomics

Project Summary/Abstract There has been a broad movement in psychological science, stemming from the Research Domain Criteria initiative by the National Institute of Mental Health, to study the core features of mental disorders by integrating data across levels of information (“from genomics and circuits to behavior and self-report”). Given the vast heterogeneity among those with alcohol use disorders (AUD), there has been a recent call to establish a similar Alcohol and Addictions Research Domain Criteria (AARDoC). Investigators at the National Institute on Alcohol Abuse and Alcoholism have proposed the Addictions Neuroclinical Assessment (ANA) as an organizing framework for carrying out AARDoC research, with the goal of establishing a common assessment battery to be used by researchers and clinicians. The ANA consists of three core domains that are derived from disrupted neurocircuitry in addiction: negative emotionality, incentive salience, and executive dysfunction. The ANA holds promise as a more effective way to characterize individuals with AUD and may lead to better individual treatment matching based on core neurobiologically-derived phenotypes. However, additional validation of the ANA domains must be conducted. The aims of the proposed research study will fill important gaps in the literature by validating the three ANA domains in a new and diverse sample of individuals with AUD (Aim 1), examining how the ANA domains relate to drinking behavior at baseline as well as how changes in ANA domains relate to changes in drinking over a three-month time period (Aim 2), and, as an exploratory aim, evaluating sex differences in ANA domains and sex differences in the relationship between drinking and ANA domains (Aim 3). In order to achieve these aims, this study will leverage data (N=264) from two longitudinal studies with nearly identical recruitment and assessment strategies. Both studies conducted in depth assessment, including neuroimaging, neuropsychological, behavioral, and self-report measures, assessed at an initial assessment and at a three-month follow-up. Importantly, the included studies represent AUD diversity in several key ways: the individuals in these samples report a range of AUD severity, they vary with respect to treatment-seeking status including many non-treatment seekers who are representative of the majority of individuals who meet criteria for AUD, and the sample is diverse in terms of racial/ethnic and socioeconomic representation. Thus, this combined sample provides rich data from across levels of analysis (neurocircuitry, cognitive, behavioral, self-report) and presents a unique opportunity to use advanced quantitative methods, including exploratory structural equation modeling (Aims 1, 2, and 3), latent change score modeling (Aim 2), and measurement invariance testing (Aims 2 and 3), to further validate the ANA domains and explore how they relate to changes in drinking behavior over time. Findings from this study will be important for testing AARDoC and how AARDoC domains relate to clinically relevant alcohol behavior change. Ultimately, findings will inform measurement-based care and precision medicine in AUD.

项目摘要/摘要 基于研究领域的标准，心理科学的运动广泛 美国国家心理健康研究所的倡议，通过整合来研究精神障碍的核心特征 跨信息级别的数据（“从基因组学和电路到行为和自我报告”）。考虑到差距 在患有酒精使用障碍的患者中的异质性（AUD），最近有一个呼吁建立一个 类似的酒精和成瘾研究领域标准（AARDOC）。美国国家研究所的调查人员 酗酒和酗酒提出了成瘾神经临床评估（ANA）作为 组织框架进行AARDOC研究，目的是建立共同的评估 用于研究人员和临床医生使用的电池。 ANA由得出的三个核心域组成 来自成瘾的神经记录的破坏：负面情绪，激励性显着性和执行功能障碍。 ANA将承诺作为表征AUD的个人的更有效的方式，并可能会带来更好 基于核心神经生物学衍生的表型的个体治疗匹配。但是，其他 必须对ANA域进行验证。拟议的研究的目的将填补重要的 通过验证具有AUD的个体的新和潜水员样本中的三个ANA域，在文献中的差距 （AIM 1），检查ANA域与基线时饮酒行为的关系以及如何变化 ANA领域与三个月内饮酒的变化有关（AIM 2），作为探索性目的， 评估ANA领域的性别差异和饮酒与ANA之间关系的性别差异 域（目标3）。为了实现这些目标，本研究将利用两个纵向的数据（n = 264） 通过几乎相同的招聘和评估策略进行研究。两项研究都深入进行 评估，包括神经影像学，神经心理学，行为和自我报告措施，评估 初步评估和三个月的随访。重要的是，纳入的研究代表听觉多样性 以几种关键的方式：这些样本中的个人报告了一系列的听觉严重性，它们因 寻求治疗的地位，包括许多代表大多数的非治疗寻求者 符合AUD标准的个人，样本在种族/种族和社会经济方面是潜水员 表示。这是该组合样本提供了来自分析级别的丰富数据（神经通路，， 认知，行为，自我报告），并提供了使用高级定量方法的独特机会， 包括探索性结构方程建模（目标1、2和3），潜在变化评分建模（AIM 2）， 和测量不变性测试（目标2和3），以进一步验证ANA域并探索它们如何 涉及随着时间的推移饮酒行为的变化。这项研究的发现对于测试AARDOC很重要 以及AARDOC领域与临床相关的酒精行为变化的关系。最终，调查结果将告知 基于测量的护理和精确医学。