Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health

运动后的生活：先前的受伤和久坐行为是后来健康状况不佳的机制

基本信息

批准号：
10253367
负责人：
Jacob J Capin
金额：
$ 39.76万
依托单位：
MARQUETTE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-22 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10253367
关键词：
Adult Age American Athletic Behavior Therapy Body Composition Body fat Chronic Disease Clinical Counseling Data Degenerative polyarthritis Delaware Development Disease Doctor of Philosophy Equipment Exercise Faculty Female Funding Future General Population Goals Guidelines HRK gene Health Health Promotion Injury Intervention Intervention Studies Knee Injuries Laboratories Lead Life Longevity Longitudinal Studies Manuscripts Medical Mentors Methods Minority Musculoskeletal National Institute of Child Health and Human Development Outcome Participant Pattern Peer Review Physical activity Physical therapy Play Population Populations at Risk Positioning Attribute Procedures Publications Quality of life Recording of previous events Rehabilitation therapy Research Research Assistant Research Support Research Training Resources Risk Risk Factors Scientist Services Sports Testing Time Underrepresented Populations United States United States National Institutes of Health Universities Walking Work aging population cardiometabolism cardiovascular disorder risk career career development chronic pain cohort college cost design disability doctoral student early onset experience hamstring health related quality of life healthspan high school improved innovation longitudinal analysis male middle age moderate-to-vigorous physical activity mortality musculoskeletal injury novel peer physical therapist prevent professor programs quadriceps muscle sedentary sedentary lifestyle success

项目摘要

PROJECT SUMMARY/ABSTRACT Approximately 8.5 million high school and collegiate athletes engage annually in competitive sport. While competitive sport offers many benefits, it also poses underappreciated risks to long-term health. Competitive sport profoundly increases risk for injury (e.g., knee injury) and may position athletes for early onset of chronic diseases (e.g., osteoarthritis), chronic pain, poor health-related quality of life, and disability. Preliminary evidence indicates former athletes in mid-life (mean age 53) perform worse on functional tests than non-athlete peers, but did not account for prior injury status. Quantifying function in former athletes with and without a prior injury and non-athlete controls is therefore critical to informing targeted interventions and ultimately increasing healthspans and quality of life. One modifiable factor that may explain the association between sports participation and poor long-term health is physical activity (PA) patterns including prolonged sedentary behavior (SB). Even among adults who meet recommended PA guidelines, SB is strongly associated with a host of poor outcomes including chronic disease and all-cause mortality. Current male professional athletes are substantially more sedentary outside their practice times than non-athletes, but whether this harmful pattern of SB also exists in amateur (e.g., high school, collegiate) or female athletes or persists in former athletes is unknown. The long-term research goal is to improve musculoskeletal, cardiometabolic, and general health and function across the lifespan of male and female former athletes, emphasizing early behavioral interventions that prevent this underrepresented and at-risk population from developing chronic diseases by mid-life. The overarching hypothesis is that former athletes, especially those with a prior injury, will have poorer function and health in mid-life and that current and former athletes will engage in greater overall and longer bouts of SB compared to matched non-athletes. Using a cross-sectional design, Aim 1 will compare function, strength, and cardiometabolic indicators among former athletes with and without prior knee injury and non- athlete matched controls in mid-life (age 45-64). Hypothesis 1 is that former athletes with a prior injury will have the poorest (1a) function (30-second chair stand, 6-minute walk, stair climb), (1b) quadriceps and hamstring strength, and (1c) cardiometabolic indicators (body composition, cardiovascular disease risk). Aim 2 will compare SB and PA patterns in current (age 18-25) and mid-life former athletes to matched non-athlete controls. Hypothesis 2.1 is that current athletes will have greater SB, longer SB bouts, and higher levels of moderate-to-vigorous PA. Hypothesis 2.2 is that former athletes in mid-life will have greater SB, longer SB bouts, and lower PA levels. Identifying and ultimately intervening on risk factors for early chronic disease will not only benefit many millions of male and female former athletes—a group in which minorities are increasingly more represented than in the overall United States population—but also provide an efficient means to prevent or delay chronic disease development in the population at large, a recent NIH emphasis (e.g., PA-18-849).

项目概要/摘要每年约有 850 万高中和大学运动员参加竞技体育运动。竞技运动带来了许多好处，但它也给长期健康带来了未被充分认识的风险。运动会普遍增加受伤风险（例如膝盖受伤），并可能导致运动员早期出现慢性病疾病（例如骨关节炎）、慢性疼痛、健康相关的生活质量差和残疾。有证据表明，中年时期的前运动员（平均年龄 53 岁）在功能测试中的表现比非运动员差同行，但没有考虑到以前有或没有受伤的前运动员的功能。因此，伤害和非运动员控制对于为有针对性的干预措施提供信息并最终增加健康寿命和生活质量可以解释运动之间的关联。身体活动 (PA) 模式（包括长时间久坐）会影响参与度和长期健康状况不佳即使在符合推荐的 PA 指南的成年人中，SB 也与行为密切相关。许多不良结果，包括慢性病和全因死亡率。与非运动员相比，他们在训练时间之外久坐的次数要多得多，但这是否有害 SB 模式也存在于业余运动员（例如高中、大学）或女运动员中，或者持续存在于以前的运动员中运动员的长期研究目标是改善肌肉骨骼、心脏代谢和一般功能。男性和女性前运动员一生的健康和功能，强调早期行为预防这一代表性不足和高危人群罹患慢性病的干预措施最重要的假设是，前运动员，尤其是那些曾受过伤的运动员，情况会更糟。中年的功能和健康，现任和前任运动员将参与总体上更大、更长时间的活动 SB 回合与匹配的非运动员进行比较使用横截面设计，目标 1 将比较功能，以前有或没有膝伤和非膝伤的前运动员的力量和心脏代谢指标中年时期（45-64 岁）的运动员与对照组相匹配假设 1 是以前受过伤的运动员会患有这种疾病。最差的 (1a) 功能（30 秒椅子站立、6 分钟步行、爬楼梯）、(1b) 股四头肌和腿筋强度，以及 (1c) 心脏代谢指标（身体成分、心血管疾病风险）。将当前（18-25 岁）和中年前运动员与匹配的非运动员的 SB 和 PA 模式进行比较假设 2.1 是当前运动员将有更大的 SB、更长的 SB 回合和更高的水平。假设 2.2 是中年时期的前运动员会有更大的 SB、更长的 SB。识别并最终干预早期慢性疾病的危险因素将有助于减少发作和降低 PA 水平。不仅许多人受益于数以百万计的男性和女性前运动员——在这个群体中，少数族裔越来越多地受益比美国总人口的代表性更高，但也提供了一种有效的手段来预防或延缓大众慢性疾病的发展，这是 NIH 最近的重点（例如，PA-18-849）。