Impacts of Sleep and Circadian Biology on Alzheimer's Disease and Aging: A Focus on Genetics and Genomics

睡眠和昼夜节律生物学对阿尔茨海默病和衰老的影响：关注遗传学和基因组学

基本信息

批准号：
10237478
负责人：
VIVEK KUMAR
金额：
$ 4.14万
依托单位：
JACKSON LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10237478
关键词：
Affect Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease model Animal Model Area Attenuated Biology Biology of Aging Blood Vessels Career Mobility Circadian Rhythms Clinical Collaborations Computational Biology Data Data Analyses Data Set Development Disadvantaged Discipline Disease Disease Progression Educational process of instructing Educational workshop Ethics Event Faculty Focus Groups Fostering Funding Future Genetic Genetic Markers Genomic approach Genomics Grant Human Impaired cognition Investigation Laboratory mice Learning Metabolism Modeling Molecular Morehouse School of Medicine Mus Nerve Degeneration Neurobiology Outcome Participant Pattern Postdoctoral Fellow Public Health Research Research Personnel Research Project Grants Resources Schedule Scholarship Science Scientist Seeds Series Shock Sleep Sleep disturbances Societies System Technology The Jackson Laboratory Time Training Underrepresented Minority abeta accumulation career career development circadian clinical biomarkers epigenomics experience falls genetic approach genomic biomarker genomic data graduate student insight interest learning materials next generation novel posters programs recruit single-cell RNA sequencing symposium transcriptome sequencing translational approach

项目摘要

PROJECT SUMMARY An emerging area of investigation is the relationship between aging, sleep and circadian rhythm, and Alzheimer’s disease (AD) progression. For example, the AD hallmark of Aβ aggregation is associated with changes in sleep- wake patterns and circadian-related metabolism. As these changes occur years prior to clinical manifestations of AD, they may be early events in AD. To understand this relationship, the fields of sleep/circadian biology and AD are taking similar strategies that include genetic and biomarker studies in humans and model organisms such as the mouse, and research is converging on recent advances in genomic technologies (e.g., single-cell RNA-seq and epigenomics) that allow more precise description of molecular and cellular changes that occur as a function of age, sleep/circadian rhythm, and AD progression. As studies in these fields are at the nascent and critical stage of intersection, we recognize an unmet need for investigators in sleep/circadian biology to learn from their colleagues in AD, and vice versa. Currently, no conference in the aging/AD field incorporates sleep/circadian biology, let alone focuses on genetics, genomics, and computational biology approaches. To fill this gap, we propose the unique and timely interdisciplinary conference “Impacts of Sleep and Circadian Biology on Alzheimer’s Disease and Aging: a Focus on Genetics and Genomics” to ignite interactions among a focused group of scientists and trainees from these fields and to foster future collaborations. We propose an annual, intensive 3-day conference beginning in October, 2021 at The Jackson Laboratory in Bar Harbor, ME. We will bring together 50 scientists -- graduate students, postdoctoral fellows, and junior and senior investigators -- from the fields of aging/AD, neurodegeneration, genetics of sleep/circadian biology, genetics, and computational biology. In Aim 1, we will organize this interdisciplinary conference on sleep/circadian biology and AD with a focus on genetic and genomic approaches. Invited speakers and session topics will represent a variety of disciplines that aim to solve questions related to AD. Each day a morning seminar will introduce trainees in the AD field to the fundamentals of sleep/circadian biology and advanced computational approaches in genetics and genomics while a hands-on afternoon workshop will focus on 'omics' analyses to spur the trainees' own research. In Aim 2, we will promote interactions that foster collaborative research and career advancement. We will include breaks and a poster session as opportunities for free-form discussions as well as devote one workshop to career development, including grantsmanship and ethics. To foster inclusive and creative science, in Aim 3 we will focus on recruitment of diverse attendees, utilizing our partnership societies and networks to recruit underrepresented minority and disadvantaged attendees, as well as offering scholarships to those who qualify and are in need. We anticipate that the conference and workshops will cross-pollinate the fields of sleep/circadian biology and AD and seed new collaborations while equipping the next generation of AD and sleep/circadian biology researchers with the ability to harness advanced computational approaches in their research.

项目概要一个新兴的研究领域是衰老、睡眠和昼夜节律与阿尔茨海默病之间的关系例如，AD 的 Aβ 聚集特征与睡眠的变化有关。唤醒模式和昼夜节律相关的代谢由于这些变化发生在临床表现之前数年。睡眠/昼夜节律生物学和 AD 的早期事件可能是 AD 的早期事件。 AD 正在采取类似的策略，包括对人类和模式生物进行遗传和生物标志物研究例如小鼠，研究正在集中于基因组技术的最新进展（例如，单细胞 RNA-seq 和表观基因组学）可以更精确地描述发生的分子和细胞变化年龄、睡眠/昼夜节律和 AD 进展的函数，因为这些领域的研究还处于起步阶段。交叉的关键阶段，我们认识到睡眠/昼夜节律生物学研究人员的学习需求尚未得到满足来自 AD 领域的同事，反之亦然。目前，老龄化/AD 领域还没有会议纳入其中。睡眠/昼夜节律生物学，更不用说专注于遗传学、基因组学和计算生物学方法了。为此，我们提出了独特且及时的跨学科会议“睡眠和昼夜节律生物学的影响” 关于阿尔茨海默氏病和衰老：关注遗传学和基因组学”，以激发重点关注者之间的互动我们提议每年举办一次，由来自这些领域的科学家和受训人员组成，并促进未来的合作。我们将于 2021 年 10 月在缅因州巴港的杰克逊实验室举行为期 3 天的密集会议。汇集了 50 名科学家——研究生、博士后研究员以及初级和高级研究人员——来自衰老/AD、神经退行性疾病、睡眠遗传学/昼夜节律生物学、遗传学和计算领域在目标 1 中，我们将组织这次关于睡眠/昼夜节律生物学和 AD 的跨学科会议。受邀演讲者和会议主题将重点关注遗传和基因组方法。旨在解决 AD 相关问题的学科每天都会在上午的研讨会上介绍受训者。 AD 领域涉及睡眠/昼夜节律生物学的基础知识以及遗传学和生物医学领域的高级计算方法下午的实践研讨会将重点关注“组学”分析，以激发学员自己的研究。在目标 2 中，我们将促进促进合作研究和职业发展的互动。休息和海报会议作为自由讨论的机会，并专门举办一次职业研讨会为了促进包容性和创造性的科学，我们将在目标 3 中重点关注。关于招募多样化的与会者，利用我们的伙伴关系协会和网络来招募代表性不足的人员少数民族和弱势参加者，以及为符合资格和有需要的人提供奖学金。预计会议和研讨会将在睡眠/昼夜节律生物学和AD领域进行异花授粉并播种新的合作，同时为下一代 AD 和睡眠/昼夜节律生物学研究人员提供装备能够在研究中利用先进的计算方法。