Impacts of Sleep and Circadian Biology on Alzheimer's Disease and Aging: A Focus on Genetics and Genomics

睡眠和昼夜节律生物学对阿尔茨海默病和衰老的影响：关注遗传学和基因组学

• 批准号: 10378650
• 负责人: VIVEK KUMAR
• 金额: $ 4.14万
• 依托单位: JACKSON LABORATORY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10378650
• 关键词: Affect; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease model; Animal Model; Area; Attenuated; Biology; Biology of Aging; Blood Vessels; Career Mobility; Circadian Rhythms; Clinical; Collaborations; Computational Biology; Data; Data Analyses; Data Set; Development; Disadvantaged; Discipline; Disease; Disease Progression; Educational process of instructing; Educational workshop; Ethics; Event; Faculty; Focus Groups; Fostering; Funding; Future; Genetic; Genetic Markers; Genomic approach; Genomics; Grant; Human; Impaired cognition; Investigation; Laboratory mice; Learning; Metabolism; Modeling; Molecular; Morehouse School of Medicine; Mus; Nerve Degeneration; Neurobiology; Outcome; Participant; Pattern; Postdoctoral Fellow; Public Health; Research; Research Personnel; Research Project Grants; Resources; Schedule; Scholarship; Science; Scientist; Seeds; Series; Shock; Sleep; Sleep disturbances; Societies; System; Technology; The Jackson Laboratory; Time; Training; Underrepresented Minority; abeta accumulation; career; career development; circadian; circadian biology; clinical biomarkers; epigenomics; experience; falls; genetic approach; genomic biomarker; genomic data; graduate student; insight; interest; learning materials; next generation; novel; posters; programs; recruit; single-cell RNA sequencing; symposium; transcriptome sequencing; translational approach

PROJECT SUMMARY An emerging area of investigation is the relationship between aging, sleep and circadian rhythm, and Alzheimer’s disease (AD) progression. For example, the AD hallmark of Aβ aggregation is associated with changes in sleep- wake patterns and circadian-related metabolism. As these changes occur years prior to clinical manifestations of AD, they may be early events in AD. To understand this relationship, the fields of sleep/circadian biology and AD are taking similar strategies that include genetic and biomarker studies in humans and model organisms such as the mouse, and research is converging on recent advances in genomic technologies (e.g., single-cell RNA-seq and epigenomics) that allow more precise description of molecular and cellular changes that occur as a function of age, sleep/circadian rhythm, and AD progression. As studies in these fields are at the nascent and critical stage of intersection, we recognize an unmet need for investigators in sleep/circadian biology to learn from their colleagues in AD, and vice versa. Currently, no conference in the aging/AD field incorporates sleep/circadian biology, let alone focuses on genetics, genomics, and computational biology approaches. To fill this gap, we propose the unique and timely interdisciplinary conference “Impacts of Sleep and Circadian Biology on Alzheimer’s Disease and Aging: a Focus on Genetics and Genomics” to ignite interactions among a focused group of scientists and trainees from these fields and to foster future collaborations. We propose an annual, intensive 3-day conference beginning in October, 2021 at The Jackson Laboratory in Bar Harbor, ME. We will bring together 50 scientists -- graduate students, postdoctoral fellows, and junior and senior investigators -- from the fields of aging/AD, neurodegeneration, genetics of sleep/circadian biology, genetics, and computational biology. In Aim 1, we will organize this interdisciplinary conference on sleep/circadian biology and AD with a focus on genetic and genomic approaches. Invited speakers and session topics will represent a variety of disciplines that aim to solve questions related to AD. Each day a morning seminar will introduce trainees in the AD field to the fundamentals of sleep/circadian biology and advanced computational approaches in genetics and genomics while a hands-on afternoon workshop will focus on 'omics' analyses to spur the trainees' own research. In Aim 2, we will promote interactions that foster collaborative research and career advancement. We will include breaks and a poster session as opportunities for free-form discussions as well as devote one workshop to career development, including grantsmanship and ethics. To foster inclusive and creative science, in Aim 3 we will focus on recruitment of diverse attendees, utilizing our partnership societies and networks to recruit underrepresented minority and disadvantaged attendees, as well as offering scholarships to those who qualify and are in need. We anticipate that the conference and workshops will cross-pollinate the fields of sleep/circadian biology and AD and seed new collaborations while equipping the next generation of AD and sleep/circadian biology researchers with the ability to harness advanced computational approaches in their research.

项目摘要 新兴的调查领域是衰老，睡眠和昼夜节律与阿尔茨海默氏症之间的关系 疾病（AD）进展。例如，Aβ聚集的AD标志与睡眠的变化有关 唤醒模式和与昼夜节律有关的代谢。由于这些变化发生在临床表现之前的几年 在广告中，它们可能是广告中的早期事件。为了了解这种关系，睡眠/昼夜生物学领域和 广告正在采用类似的策略，包括人类和模型生物的遗传和生物标志物研究 例如小鼠，以及研究基因组技术的最新进展（例如，单细胞） RNA-seq和表观基因组学）允许对分子和细胞变化的更精确描述为 年龄，睡眠/昼夜节律和AD进展的功能。由于这些领域的研究处于新生和 十字路口的关键阶段，我们认识到对睡眠/昼夜生物学研究人员学习的需求未满足 来自AD的同事，反之亦然。目前，在老龄化/广告领域有没有会议 睡眠/昼夜节律生物学，更不用说专注于遗传学，基因组学和计算生物学方法。填充 这个差距，我们提出了独特及时的跨学科会议，“睡眠和昼夜节律生物学的影响 关于阿尔茨海默氏病和衰老：对遗传学和基因组学的关注”，以激发重点的相互作用 这些领域的科学家和学员小组，以促进未来的合作。我们建议一年一度 2021年10月从我的杰克逊实验室开始，为期3天的大会会议。我们将 从来自 衰老/AD的领域，神经变性，睡眠/昼夜生物学的遗传学，遗传学和计算 生物学。在AIM 1中，我们将组织这个关于睡眠/昼夜生物学的跨学科会议，并与 专注于遗传和基因组方法。受邀演讲者和会议主题将代表各种各样的 旨在解决与AD有关的问题的学科。每天早上开创性的开创性都会在 广告领域涉及遗传学和高级计算方法的睡眠基础知识 基因组学虽然下午的讲习班将重点介绍“ OMIC”分析，以刺激培训自己的研究。 在AIM 2中，我们将促进互动，以促进协作研究和职业发展。我们将包括 休息和海报会议是自由形式讨论的机会，并将一个研讨会投入职业 发展，包括赠款和道德。为了培养包容性和创造性科学，在AIM 3中，我们将集中精力 利用我们的合伙协会和网络招募潜水员的参与者招募人数不足 少数派和处境不利的与会者，并向有资格和有需要的人提供奖学金。 预计会议和研讨会将交叉授粉睡眠/昼夜生物学领域和广告 和种子新的合作，同时为下一代广告和睡眠/昼夜生物学研究人员提供 具有利用高级计算方法的能力。