Timing Of Exercise In Concussed Rat Athletes

脑震荡大鼠运动员的运动时机

• 批准号: 10576291
• 负责人: Mayumi Lynn Prins
• 金额: $ 48.32万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10576291
• 关键词: Address; Adolescent; Adolescent and Young Adult; Adult; Affect; Age; Animals; Anxiety; Behavioral; Biogenesis; Biological Markers; Brain; Brain Concussion; Brain Injuries; Brain-Derived Neurotrophic Factor; Cerebrum; Classification; Development; Equilibrium; Exercise; Experimental Models; Exposure to; Female; Functional disorder; Glucose; Glutamates; Goals; Grant; Guidelines; Home; Impaired cognition; Injury; Male Adolescents; Mental Depression; Metabolic; Mitochondria; Modeling; Monitor; N-acetylaspartate; Physical activity; Physiology; Play; Population; Protocols documentation; Psyche structure; Rattus; Recovery; Reporting; Research; Rest; Risk; Rodent; Role; Running; Severities; Sex Differences; Social Interaction; Socialization; Sports; Standardization; Study models; Symptoms; Synaptophysin; Time; Training; Traumatic Brain Injury; Work; adolescent health; allodynia; brain health; clinical translation; clinically relevant; cognitive testing; experimental study; glucose metabolism; improved outcome; insight; male; metabolic depression; metabolic rate; mild traumatic brain injury; neurochemistry; pain sensitivity; prevent; reduce symptoms; response; response to brain injury; sedentary; sex

Project Summary/Abstract Repeat concussions are a growing concern for adolescents and young adult athletes. Experimentally one of the problems is that no one has been addressing this in an “athlete” model. Growing evidence shows that the brains of those that exercise regularly (athletes) are very different than those that are sedentary. These differences will affect how the “athlete brain” responds to concussive injuries. In this application we have developed a rathlete model to study the effects of concussive injuries and recovery between the athlete brain and non-athlete brain in both male and female rats. This work will not only provide important information regarding brain injury research, but emphasize the role of exercise in adolescent health.

项目摘要/摘要 重复咨询是青少年和年轻运动员日益关注的问题。实验 问题之一是，没有人在“运动员”模型中解决这个问题。越来越多的证据 表明那些定期运动的人（运动员）的大脑与那些的大脑大不相同 久坐。这些差异将影响“运动员大脑”如何应对脑震荡。在这个 应用我们已经开发了一个相当相当的模型来研究脑震荡和恢复的影响 在男性和雌性大鼠的运动员大脑和非运动员大脑之间。这项工作不仅会 提供有关脑损伤研究的重要信息，但强调运动在 青春期健康。