Cerebral Substrate Support After Traumatic Brain Injury

脑外伤后的脑基质支持

基本信息

批准号：
10199063
负责人：
Mayumi Lynn Prins
金额：
$ 34.13万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-30 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10199063
关键词：
Anaerobic Bacteria Animals Apoptosis Basic Science Behavioral Biogenesis Brain Brain Injuries Cells Cerebrum Clinical Clinical Research Cognitive Cognitive deficits Coupled Craniocerebral Trauma Development Diagnostic Dose Effectiveness Equilibrium Female Free Radicals Gender Glucose Glutamates Goals Grant Histology Human Impairment Injury Ketones Lesion Mental Depression Metabolic Metabolic dysfunction Metabolism Mitochondria Motor Necrosis Neurons Outcome Outcome Measure Patients Pentosephosphate Pathway Physiological Production Property Protons Pyruvate Rattus Recovery Recovery of Function Reporting Research Research Personnel Respiration Sex Differences Supplementation Synaptic Transmission Synaptic plasticity TBI treatment Therapeutic Time Traumatic Brain Injury behavioral outcome beta-Hydroxybutyrate compare effectiveness effectiveness evaluation functional outcomes glucose metabolism glucose uptake head-to-head comparison improved injury recovery male metabolic depression mitochondrial dysfunction neurochemistry neuronal survival neuroprotection prevent response sex tool treatment effect

项目摘要

Project Summary/Abstract Basic science and clinical research has shown that traumatic brain injury (TBI) results in immediate and transient increases in glucose uptake (CMRglc) to re-establish ionic equilibrium and neurochemical imbalances. This is rapidly followed by a prolonged period of glucose metabolic depression, a hallmark of TBI and a critical component of the cerebral metabolic crisis. During this depression the brain is vulnerable and there are many problems with glucose metabolism. We have shown that early administration of alternative substrates after injury reduces cell loss, improves cellular energy and early beahvioral outcomes. This grant will directly compare the capacity of alternative substrates to decrease metabolic crisis, improve mitochondrial energy, decrease free radical damage and improve long-term function in both male and female subjects. Findings from these studies will establish which brain fuels are optimal for recovery in both genders after TBI.

项目概要/摘要基础科学和临床研究表明，创伤性脑损伤（TBI）会立即导致葡萄糖摄取 (CMRglc) 短暂增加，以重建离子平衡和神经化学不平衡。随后迅速出现长时间的葡萄糖代谢抑制，这是一个标志 TBI 的发生和脑代谢危象的一个重要组成部分。在抑郁症期间，大脑身体脆弱，糖代谢存在很多问题。我们早已经证明损伤后施用替代底物可减少细胞损失，提高细胞能量并早期行为结果。这笔赠款将直接比较替代基质的容量减少代谢危机，提高线粒体能量，减少自由基损伤，改善男性和女性受试者的长期功能。这些研究的结果将确定哪些大脑燃料对于两性 TBI 后的恢复都是最佳的。