Neurobehavioral & Psychiatry Core

神经行为

• 批准号: 10561652
• 负责人: Jennifer E Iudicello
• 金额: $ 16.72万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-24 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10561652
• 关键词: AIDS clinical trial group; AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Anhedonia; Anti-Retroviral Agents; Anxiety; Anxiety Disorders; Area; Authorization documentation; Basic Science; Biological; Biological Factors; Biological Markers; COVID-19 pandemic; Certification; Clinical; Clinical Research; Clinical Trials; Clinical assessments; Cognition; Cognitive; Collaborations; Complex; Consult; Consultations; Cytomegalovirus; Data; Depressed mood; Development; Diagnostic; Dimensions; Disease; Disparity; Doctor of Philosophy; Educational workshop; Evaluation; Extramural Activities; Fright; Funding; Goals; HIV; HIV Seronegativity; Health; Impairment; Individual; Inflammatory; Interdisciplinary Study; Interleukin-6; International; Intervention; Investigation; Leadership; Life; Link; Loneliness; Major Depressive Disorder; Maps; Medical; Mental Depression; Mental Health; Mental disorders; Mentors; Metabolic syndrome; Methods; Mood Disorders; Moods; Neurocognition; Neurocognitive; Neurocognitive Deficit; Neurologic; Neuropsychology; Outcome; Participant; Pathogenesis; Persons; Phenotype; Pilot Projects; Process; Psychiatric Diagnosis; Psychiatrist; Psychiatry; Psychological Factors; Psychosocial Factor; Registries; Reproducibility; Research; Research Design; Research Personnel; Research Priority; Resources; Risk; Role; Science; Self Efficacy; Services; Social support; Standardization; Stress; Symptoms; Telephone; Time; Training; Translational Research; Trauma; Underserved Population; Validation; Vinorelbine tartrate; Viral Load result; Visit; Work; adverse childhood events; authority; career development; clinically relevant; co-infection; comorbidity; daily functioning; data standards; depressive symptoms; follow-up; gut-brain axis; health disparity; immune depression; instrument; low socioeconomic status; meetings; metabolome; microbiome; multidisciplinary; neuroAIDS; neurobehavioral; neuroinflammation; neurotoxic; outreach; psychiatric symptom; recruit; remote assessment; resilience; social stigma; standardize measure; substance use; translational study

PROJECT SUMMARY/ABSTRACT: NEUROBEHAVIORAL AND PSYCHIATRY CORE The NeuroBehavioral and Psychiatry (NBP) Core, previously the Neurobehavioral Unit of the NeuroAssessment Core from the prior funding period, is a new Core proposed for the competing HNRC renewal. The new NBP Core will apply assessment expertise in conducting comprehensive neuropsychological, psychiatric (including both psychiatric diagnoses and dimensional symptom levels), substance use, and daily functioning assessments. This supports the Center’s new emphasis on neurobehavioral phenotypes among persons with HIV (PWH), and links them to medical and biological data from other HNRC Cores and associated studies. NBP aims map directly onto the Office of AIDS Research Priorities under the major topic of “HIV- associated comorbidities, coinfections, and complications” by addressing areas of neurologic consequences, mental illness, and health disparities. The goals of the NBP Core are to contribute to the identification of individuals who have evidenced changes in cognition, depression and daily functioning, and to provide comprehensive longitudinal neurocognitive, psychiatric, substance use and everyday functioning assessments on the PWH and HIV- comparison participants. Importantly, our core will provide the neuropsychological and psychiatric (including depression) assessments in order to determine neurobehavioral phenotypes. We aim to facilitate and enhance multidisciplinary research in neuroHIV by providing a range of services, training and scientific consultation to projects such as investigator-driven R01s, R21s, and R34s, international neuroHIV studies, and a variety of intra- and extramural investigations. Historically, the NBP Core and its investigators have been national and international leaders in the neuroHIV field, spurring the development of both international harmonization of assessments and new methods, while adapting to the continually evolving scientific landscape. We aim to continue in this regard. In addition, in support of the HNRC’s increased focus on combined neurobehavioral phenotypes among PWH, and participants who change over time, the NBP Core will administer a more detailed psychiatric assessment which will examine detailed components of depression (e.g., anhedonia, apathy), anxiety, stress, adverse childhood events and life trauma, and resilience and social support. All of these factors may influence the complex relationships among neurocognition, depression, HIV disease and other clinical outcomes. We will work hand-in-hand with 1) the NeuroMedical Core to identify underlying biological mechanisms of neurobehavioral phenotypes, exploring connections to HIV disease (e.g., CSF viral load), inflammatory processes/biomarkers (e.g., IL-6), other medical comorbidities (e.g., metabolic syndrome), co- infections (e.g., CMV; NM and NVB Cores); and 2) with the MIBI Core to explore effects of microbiome and metabolome on neurobehavioral outcomes and/or phenotypes; and with both NM and NVB Cores regarding neuroinflammation and long-term protective and/or neurotoxic effects of antiretrovirals.

项目摘要/摘要：神经行为和精神病学核心 神经行为和精神病学 (NBP) 核心，以前是神经行为科 上一资助期的 NeuroAssessment Core 是为竞争性 HNRC 更新而提议的新核心。 新的 NBP 核心将应用评估专业知识来进行全面的神经心理学、 精神科（包括精神科诊断和维度症状水平）、物质使用和日常 这支持了该中心对神经行为表型的新重视。 艾滋病毒感染者 (PWH)，并将他们与其他 HNRC 核心和相关的医疗和生物数据联系起来 NBP 的研究目标直接映射到艾滋病研究优先事项办公室，其主要主题是“艾滋病毒- 相关的合并症、合并感染和并发症”通过解决神经系统后果领域， NBP 核心的目标是帮助识别精神疾病和健康差异。 认知、抑郁和日常功能发生明显变化的个人，并提供 全面的纵向神经认知、精神、物质使用和日常功能评估 重要的是，我们的核心将提供神经心理学和艾滋病毒比较参与者的信息。 我们的目标是进行精神（包括抑郁症）评估以确定神经行为表型。 通过提供一系列服务、培训和培训，促进和加强神经艾滋病毒的多学科研究 为研究者驱动的 R01s、R21s 和 R34s、国际 NeuroHIV 等项目提供科学咨询 历史上，NBP 核心及其研究人员进行了各种研究以及各种校内和校外调查。 是神经艾滋病领域的国内和国际领导者，推动了国际和国家的发展 协调评估和新方法，同时适应不断发展的科学格局。 此外，我们的目标是继续支持 HNRC 对联合的关注。 NBP 核心将管理 PWH 中的神经行为表型以及随时间变化的参与者 更详细的精神评估，将检查抑郁症的详细组成部分（例如快感缺失、 冷漠）、焦虑、压力、不良童年事件和生活创伤，以及适应力和社会支持。 因素可能会影响神经认知、抑郁症、艾滋病毒疾病和其他疾病之间的复杂关系 我们将与 1) 神经医学核心携手合作，确定潜在的生物学结果。 神经行为表型的机制，探索与艾滋病毒疾病的联系（例如脑脊液病毒载量）， 炎症过程/生物标志物（例如 IL-6）、其他医学合并症（例如代谢综合征）、合并症 感染（例如 CMV、NM 和 NVB 核心）；2) 使用 MIBI 核心探索微生物组和 代谢组对神经行为结果和/或表型的影响；以及 NM 和 NVB 核心 神经炎症以及抗逆转录病毒药物的长期保护和/或神经毒性作用。