Data Management and Analysis Core

数据管理与分析核心

• 批准号: 10271835
• 负责人: JENNIFER L. CLARKE
• 金额: $ 16.8万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10271835
• 关键词: Address; Biochemical; Bioinformatics; Biological; Biological Sciences; Biomedical Research; Biotechnology; Chemicals; Collaborations; Collection; Communication; Communication Research; Communities; Complex; Computational Biology; Computer software; Core Facility; Data; Data Analyses; Data Management Resources; Data Science; Data Science Core; Data Set; Data Storage and Retrieval; Development; Education; Educational workshop; Electron Microscopy; Equipment; Experimental Designs; FAIR principles; Faculty; Fee-for-Service Plans; Fees; Funding; Generations; Goals; Grant; Human Resources; Image; Individual; Infrastructure; Internet; Laboratories; Libraries; Link; Manuscripts; Molecular Biology; Nebraska; Outcome; Pathway interactions; Peer Review; Phase; Public Health; Publications; Research; Research Personnel; Resources; Role; Seeds; Services; Statistical Data Interpretation; Technical Expertise; Time; Training; Universities; Workforce Development; base; biomedical data science; biomedical resource; cohort; complex data; computational pipelines; computational platform; computer science; computing resources; cost; cost effective; cryogenics; cyber infrastructure; data exchange; data infrastructure; data management; data pipeline; data portal; data science management; data science resource; experimental study; knowledge base; member; molecular imaging; research facility; statistics; structural biology; tool; web page; web portal; webinar; x-ray free-electron laser

PROJECT SUMMARY/ABSTRACT The broad, long-term goal of the Data and Life Sciences Core (DLSC) within the Nebraska Center for Integrated Biomolecular Communication (CIBC) is to serve as a critical, sustainable resource for biomedical data science and data management expertise, service, and education at the University of Nebraska. The research performed by CIBC investigators will continue to result in the creation of large, complex data sets, particularly for those researchers with projects involving high-throughput biological data and molecular biology data. Proper experimental design, data generation, and subsequent analyses of these data sets requires analytical and computational expertise, access to scientific equipment and relevant technical expertise, high-throughput computing, and resources for data management. Coordinated access to such services is often cost prohibitive and nonintuitive for individual laboratories. Another obstacle faced by many biomedical researchers, including those affiliated with CIBC, is the timely and comprehensive sharing of research data and research findings with collaborators, stakeholders, and the public. To address these issues, CIBC will continue to support DLSC. DLSC provides hardware, software, and expertise in experimental design, bioinformatics, computational biology, statistics, computer science, data management, and advanced cyberinfrastructure to CIBC investigators and the wider university community. To date, DLSC has launched a web portal for data transfer, hosting, and sharing through Globus and the University of Nebraska’s Holland Computing Center; initiated collaborations with CIBC researchers leading to presentations and publications; provided access to analytical software; and hosted training and workforce development opportunities. The immediate goal of DLSC for Phase 2 is to expand and strengthen the core’s data science and data management infrastructure, services, expertise, and educational programming in support of CIBC investigators and the Center’s overall goals and long-term sustainability. This will be achieved through four aims: 1) expand an existing computational platform for data storage, analysis, and management to include support for biomolecular imaging experiments and integration with the Research Space platform, 2) promote core sustainability by initiating collaborations with personnel across the University of Nebraska campuses to enable complex, interdisciplinary biomedical projects that require expertise in data science and data management, 3) serve a critical, sustainable role in CIBC research by collaborating on CIBC projects, both as authors on research publications relevant to CIBC and as investigators on subsequent proposals for internal and external research funding, and 4) educate CIBC members about the role of data science in chemical and biochemical research, the potential and caveats of experimental data, and start-of-the- art resources and pipelines for data preprocessing and analysis. DSLC will continue to capitalize on existing expertise at the University of Nebraska, hire needed expertise, and build long-term core sustainability.

项目摘要/摘要 内布拉斯加州综合中心内数据和生命科学核心（DLSC）的广泛，长期目标 生物分子通信（CIBC）将作为生物医学数据科学的关键，可持续资源 内布拉斯加州大学的数据管理专业知识，服务和教育。研究进行了 CIBC调查人员将继续导致创建大型，复杂的数据集，特别是对于这些数据集 研究人员的项目涉及高通量生物学数据和分子生物学数据。恰当的 实验设计，数据生成以及对这些数据集的后续分析需要分析和 计算专业知识，获得科学设备和相关技术专长，高通量 计算和数据管理的资源。协调获得此类服务的访问通常是禁止的 对于单个实验室而非直觉。许多生物医学研究人员面临的另一个障碍，包括 与CIBC相关的人，是及时，全面的研究数据和研究结果的共享 合作者，利益相关者和公众。为了解决这些问题，CIBC将继续支持DLSC。 提供实验设计，生物信息学，计算生物学的硬件，软件和专业知识， CIBC调查人员和 更广泛的大学社区。迄今为止，DLSC启动了一个用于数据传输，托管和共享的Web门户网站 通过Globus和内布拉斯加大学的荷兰计算中心；与CIBC启动合作 研究人员导致演讲和出版物；提供了对分析软件的访问；并主持 培训和劳动力发展机会。 DLSC对于第2阶段的直接目标是扩展和 加强核心的数据科学和数据管理基础架构，服务，专家和教育 支持CIBC调查人员以及中心的总体目标和长期可持续性的编程。这 将通过四个目的来实现：1）扩展一个现有的计算平台，用于数据存储，分析和 管理层以包括对生物分子成像实验的支持并与研究空间的整合 平台，2）通过与大学的人员合作来促进核心可持续性 内布拉斯加州校园能够启用复杂的跨学科生物医学项目，这些项目需要数据专业知识 科学与数据管理，3）在CIBC上合作在CIBC研究中起着至关重要的可持续作用 项目，无论是作为与CIBC相关的研究出版物的作者还是致作为随后的研究人员 内部和外部研究资金的建议，以及4）教育CIBC成员有关数据的作用 化学和生化研究的科学，实验数据的潜力和警告以及开始 用于数据预处理和分析的艺术资源和管道。 DSLC将继续利用现有的 内布拉斯加州大学的专业知识，雇用需要专业知识，并建立长期的核心可持续性。