A new PET neuroimaging probe for sigma 1 receptor

一种新的 Sigma 1 受体 PET 神经影像探针

基本信息

批准号：
10272877
负责人：
Changning Wang
金额：
$ 25.06万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10272877
关键词：
Affinity Animals Astrocytes Automation Binding Biochemical Process Brain Brain Diseases Brain imaging Cell membrane Clinical Research Clinical Trials Coupled Data Development Diagnosis Disease Drug Addiction Drug Kinetics Endocrine Endoplasmic Reticulum Evaluation Functional disorder Goals Grant Human Ideal 1 Image Imaging Device Imaging Techniques Immune In Vitro Investigative Techniques Ion Channel Kinetics Lead Ligands Maximum Tolerated Dose Measurement Measures Mechanics Medical Research Membrane Mental disorders Metabolism Methods Microglia Molecular Chaperones Nerve Degeneration Neuraxis Neurons Neurotransmitter Receptor Nuclear Envelope Oligodendroglia Opioid Pain Pain management Pathologic Pathologic Processes Pathway interactions Patients Peripheral Physiological Processes Plasma Positron-Emission Tomography Process Property Proteins Reporting Research Rodent Role Safety Sensory Specificity Structure Techniques Testing Therapeutic Tissues Tracer Translating Translational Research Validation brain research cell type design dosimetry drug discovery experience human disease human imaging human study imaging agent imaging probe imaging study improved in vivo in vivo imaging kinetic model man mitochondrial membrane molecular imaging neuroimaging non-invasive imaging nonhuman primate novel pre-clinical radiotracer receptor receptor binding receptor expression receptor function sigma-1 receptor small molecule therapeutics success technique development therapeutic target tool uptake

项目摘要

Project Summary Sigma 1 receptor (σ1R) has been implicated in multiple functions and associated with various human diseases, including brain diseases/disorders. σ1R has been reported to interact with numerous neurotransmitter receptors and ion channels, and involved in diverse basic biochemical processes and pathological conditions related to neurodegeneration, pain sensitization, psychiatric disorders, and drug addiction. Therefore, it is important to have a tool for non-invasive measurement of σ1R expression and function in vivo, and PET imaging would be an ideal tool. Unfortunately, to date, there are no suitable non-invasive neuroimaging tools for investigating these processes in animals or in man. The development of techniques for visualizing σ1R in vivo represents a key step in understanding both the normal function and pathophysiology of σ1R in brain. Moreover, these techniques will accelerate the discovery of small molecule therapeutics that selectively interacts with σ1R. The project is designed to validate a novel PET imaging probe, [18F]CNY-05, for σ1R imaging in rodents and non-human primates.

项目概要 Sigma 1 受体 (σ1R) 具有多种功能并与多种人类疾病相关，据报道，σ1R 与许多神经递质受体相互作用。和离子通道，并参与多种基本生化过程和相关的病理状况神经退行性变、疼痛敏感、精神疾病和药物成瘾因此很重要。拥有一种非侵入性测量体内 σ1R 表达和功能的工具，并且 PET 成像将一个理想的工具。不幸的是，迄今为止，还没有合适的非侵入性神经影像工具来研究这些过程在动物或人体中可视化 σ1R 的技术的发展代表了关键的一步。了解大脑中 σ1R 的正常功能和病理生理学。加速发现与 σ1R 选择性相互作用的小分子疗法。旨在验证一种新型 PET 成像探针 [18F]CNY-05，用于啮齿动物和非人类的 σ1R 成像灵长类动物。