Physiology Core

生理学核心

基本信息

批准号：
10588533
负责人：
MANAMI HARA
金额：
$ 35.25万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-12-01 至 2028-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10588533
关键词：
Adenine Nucleotides Animal Model Appetitive Behavior Area Atrophic Back Beta Cell Bioenergetics Biopsy Body Composition C-Peptide Calorimetry Cell physiology Chicago Circadian Dysregulation Circadian Rhythms Clinical Research Collaborations Core Facility Desire for food Development Diabetes Mellitus Digestive System Disorders Disease Evolution Family Fatty acid glycerol esters Functional disorder Generations Gestational Diabetes Glucose Goals Human Image Analysis Institution Insulin Resistance Knowledge Label Measurement Measures Metabolic Metabolic Diseases Microbe Mission Modeling Mus Obesity Pancreas Physiological Physiology Research Research Personnel Resources Role Services Sleep Disorders Sleep disturbances Sterols Structure Structure of beta Cell of islet Techniques Technology Tissues Training Universities assay development behavioral study diabetic experience feeding glycemic control human model human subject human tissue in vivo insulin secretion investigator training islet metabolic phenotype metabolic rate microbiome mouse model non-diabetic tool translational pipeline transplant model

项目摘要

PROJECT SUMMARY – PHYSIOLOGY CORE Physiological research in humans and animal models has been an integral part of the Chicago Diabetes Research and Training Center (DRTC) since its inception. The mission of the Physiology Core is to provide DRTC investigators with the tools and knowledge necessary to investigate the pathophysiology of diabetes and its effects on metabolically active tissues. An important evolution of this Core is the inclusion of detailed metabolic phentopying services and circadian rhythm services based at Northwestern University. This new collaborative working relationship between the University of Chicago and Northwestern University adds value to the DRTC by providing access to an array of both state-of-the-art and unique resources, technology and services that are not otherwise available through core facilities at any of the DRTC affiliated institutions. The long-range objectives and goals of this Core are to understand the pathophysiology of diabetes and its complications. The Core serves both experienced as well as novice users and functions as an important conduit for facilitating entry into the field for investigators who have not traditionally performed metabolic physiology research. In addition to consultative and experimental services, the Core provides training for investigators who wish to incorporate specialized techniques back into their own lab. The Core provides advice and hands-on-training to investigators in clinical studies of non-diabetic and diabetic humans, physiology studies of mice and mouse, mouse model generation, and cellular physiology studies. The Specific Aims of the Core are to provide advice, training, and service in each of the following areas: 1. Clinical studies of non-diabetic and diabetic human subjects. 2. Large-scale analysis of pancreatic beta-cell mass, islet size distribution, islet cellular composition and islet vasculature in the human and mouse pancreas 3. Comprehensive metabolic phenotyping of mice. 4. Generation of specialized mouse models that span disorders of metabolism and glucose. 5. Cellular physiology services, including bioenergetic analyses, metabolic flux labeling, and measurement of adenine nucleotides 6. Studies of the role of the microbiome on diabetes and obesity.

项目摘要 - 生理核心人类和动物模型的生理研究一直是芝加哥糖尿病不可或缺的一部分研究与培训中心（DRTC）自成立以来。生理学核心的使命是提供 DRTC调查人员使用所需的工具和知识来研究糖尿病和它对代谢活性组织的影响。该核心的一个重要演变是包括详细的代谢基于西北大学的Phentopying Services和昼夜节律服务。这个新的合作芝加哥大学和西北大学之间的工作关系为DRTC增添了价值提供访问不是最先进的和独特的资源，技术和服务的访问权限否则可通过任何DRTC分支机构机构的核心设施获得。远程目标该核心的目标是了解糖尿病的病理生理及其并发症。核心服务经验丰富和喷嘴用户都可以作为支持进入现场的重要渠道对于传统上不进行代谢生理学研究的研究人员。除了咨询和实验服务，核心为希望合并专业的调查人员提供培训技术回到自己的实验室。核心向临床调查人员提供建议和实践培训非糖尿病和糖尿病人类的研究，小鼠和小鼠的生理研究，小鼠模型产生，和细胞生理研究。核心的具体目的是在每种方面提供建议，培训和服务以下领域： 1。非糖尿病和糖尿病人类受试者的临床研究。 2。胰腺β细胞质量，胰岛尺寸分布，胰岛细胞组成和胰岛的大规模分析人和老鼠胰腺中的脉管系统 3。小鼠的综合代谢表型。 4。跨越代谢和葡萄糖疾病的专业小鼠模型的产生。 5。细胞生理服务，包括生物能分析，代谢通量标记和测量腺嘌呤核苷酸 6。研究微生物组在糖尿病和肥胖症中的作用。