Quantitative analysis of aging in the human pancreas

人类胰腺衰老的定量分析

• 批准号: 8444951
• 负责人: MANAMI HARA
• 金额: $ 7.9万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8444951
• 关键词: Age; Age-Years; Aging; Architecture; Autopsy; Beta Cell; Caliber; Cells; Cellular biology; Chicago; Chronic; Chronic Disease; Clinical; Collaborations; Communities; Computer Assisted; Cyclic GMP; Cystic Fibrosis; D Cells; Data Analyses; Data Set; Databases; Diabetes Mellitus; Digestive System Disorders; Disease; Endocrine; Ensure; Evaluation; Exhibits; Foundations; Funding; Future; Genes; Glucagon; Goals; Hormones; Human; Image; Image Analysis; Imaging Techniques; Individual; Institutes; Insulin; Islet Cell; Islets of Langerhans; Islets of Langerhans Transplantation; Kidney Diseases; Libraries; Malignant Neoplasms; Metabolic Diseases; Methods; Modeling; Nature; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Pancreas; Pancreas Transplantation; Pancreatitis; Pathway interactions; Physiological; Population; Process; Property; Recording of previous events; Research; Research Personnel; Risk Factors; Rodent; Shapes; Somatostatin; Spatial Distribution; Specimen; Structure; Therapeutic; Tissues; Transplantation; Universities; age effect; expectation; follow-up; human tissue; interest; islet; novel; programs; response; success; tissue resource

DESCRIPTION (provided by applicant): The islets of Langerhans which are distributed throughout the pancreas comprise 1-2% of the mass of the pancreas and contain the endocrine cells that secrete insulin (beta-cells) and other hormones. The overall goal of the studies outlined in this application is to provide a better understanding of normal physiological changes in islet number, size, shape, distribution and cellular composition associated with aging with the expectation that the results will provide a foundation to further study the processes in response to perturbations such as chronic metabolic diseases. Here we propose to use novel large-scale imaging techniques to describe and quantify changes in human pancreatic islets as a function of age. This application is a collaboration between investigators at the University of Chicago and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and has one specific aim: Specific Aim: Quantitative analysis of changes in human pancreatic islets as a function of age The proposed study will provide a detailed understanding of the effect of aging on human pancreatic islets and the genes and pathways involved. The results form the foundation for future studies of human pancreatic islets under physiological and pathophysiological conditions. The primary data and analyses will be made available to the diabetes community through an online library for follow-up analyses. PUBLIC HEALTH RELEVANCE: The overall goal of this project is to characterize the number, size, shape, distribution and cellular composition of human pancreatic islets as a function of age. The results will provide a better understanding of the normal changes in islets that occur as we age and a foundation for similar studies under other physiological and pathophysiological conditions.

描述（由申请人提供）：在整个胰腺中分布的Langerhans的胰岛占胰腺质量的1-2％，并包含分泌胰岛素（β细胞）和其他激素的内分泌细胞。本应用中概述的研究的总体目标是更好地了解与衰老相关的胰岛数量，大小，形状，分布和细胞组成的正常生理变化，并希望结果为进一步研究响应诸如慢性代谢疾病等扰动的过程提供基础。在这里，我们建议使用新型的大规模成像技术来描述和量化人类胰岛的变化作为年龄的函数。该应用是芝加哥大学的研究人员与国家糖尿病与消化和肾脏疾病研究所（NIDDK）之间的合作，并且具有一个具体目的：具体目的：对人类胰岛随着年龄的影响的变化的定量分析，建议的研究将提供对人类对人类对人类pancancreatic Islets和Genesles和该基因的影响的详细理解，并将其涉及该基因和该基因。结果构成了生理和病理生理条件下人类胰岛的未来研究的基础。主要数据和分析将通过在线图书馆向糖尿病社区提供，以进行后续分析。 公共卫生相关性：该项目的总体目标是表征人类胰岛的数量，大小，形状，分布和细胞组成的数量，与年龄的关系。结果将更好地理解随着年龄的增长，在其他生理和病理生理条件下的类似研究的基础上发生的正常变化。