Social Facilitation of Emotion Regulation in Adolescence

青春期情绪调节的社会促进

• 批准号: 10588378
• 负责人: Naomi Ilana Eisenberger
• 金额: $ 23.55万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-12 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10588378
• 关键词: Adolescence; Adolescent; Adult; Age; Amygdaloid structure; Behavior; Behavioral; Brain; Brain region; Buffers; Cognitive; Collection; Cues; Data; Decision Making; Development; Down-Regulation; Emotional; Emotions; Event; Frequencies; Friends; Functional Magnetic Resonance Imaging; Goals; Intervention; Lateral; Link; National Institute of Child Health and Human Development; Pathway interactions; Patient Self-Report; Play; Prefrontal Cortex; Regulation; Research; Rewards; Risk Behaviors; Role; Shapes; Social Environment; Social Facilitation; Source; Stimulus; Symptoms; Testing; Time; Ventral Striatum; Well in self; Work; adolescent brain development; adolescent health; age group; age related; cognitive control; cognitive reappraisal; efficacy evaluation; emotion dysregulation; emotion regulation; experience; improved; negative affect; neural; neurodevelopment; neuromechanism; novel; peer; peer influence; recruit; reward circuitry; scaffold; showing emotion; social; social interventions; success; therapy design; vulnerable adolescent

Project Summary Adolescents demonstrate a high need for emotion regulation [2-4], but often struggle to employ gold- standard regulatory strategies such as cognitive reappraisal due to underdeveloped lateral prefrontal neuroarchitecture (i.e. lateral prefrontal cortex (LPFC)), which plays a crucial role in cognitive control [5-8]. At the same time, adolescents are exquisitely sensitive to their peers [11,13-16]. Notably, neural regions linked to peer influence in adolescence, including ventral striatum (VS) and ventromedial prefrontal cortex (vmPFC), mature prior to LPFC. Thus, adolescents are uniquely poised to benefit from a social intervention designed to appropriate peer influence mechanisms towards enhancing emotion regulation efficacy. The goal of this R21 is to work with the developing brain, not against it, to utilize adolescent-emergent reward-related circuitry (VS, VMPFC) instead of LPFC to regulate emotion in adolescents. We will administer a novel paradigm during functional magnetic resonance imaging (fMRI) to examine whether adolescents (N = 50) and adults (N = 50) are more effective at down-regulating negative affect when a friend provides them with reinterpretations of negative stimuli (i.e. social reappraisal), as compared to when they reinterpret stimuli alone (i.e., cognitive reappraisal) [12]. Specifically, we will investigate whether social reappraisal is more effective and longer-lasting than cognitive reappraisal in down-regulating negative affect in adolescents and adults (Aim 1). We hypothesize that social reappraisal will be more effective and enduring than cognitive reappraisal in both groups, but that this effect will be larger in adolescents given their heightened sensitivity to peers. Furthermore, we will identify the neural mechanisms supporting social versus cognitive reappraisal and characterize age-related differences in these mechanisms (Aim 2). We will focus on examining activation in the amygdala, LPFC, VS, and VMPFC, as well as functional connectivity between these regions. We hypothesize that LPFC-amygdala connectivity will support cognitive reappraisal, which will be stronger in adults versus adolescents, whereas VS-amygdala and VMPFC-amygdala connectivity will support social reappraisal. While VS-amygdala connectivity is likely to be stronger in adolescents than adults, VMPFC- amygdala connectivity might not be given that this pathway is still developing during adolescence [21,76]. We expect that social reappraisal will have a more transformative and thus longer-lasting effect on amygdala- based representations of negative stimuli, particularly in adolescents, and will use representation similarity analysis to test this hypothesis. Examining the efficacy and neural underpinnings of social reappraisal in adolescents versus adults is an important step in advancing our understanding of how social contexts shape emotion regulation neurodevelopment, with the aim of improving adolescent health and laying the groundwork for positive emotional wellbeing into adulthood.

项目摘要 青少年表现出对情绪调节的高需求[2-4]，但经常努力使用黄金 - 标准的监管策略，例如由于前额叶发育不足而导致的认知重新评估 神经结构（即外侧前额叶皮层（LPFC）），在认知对照中起着至关重要的作用[5-8]。在 同时，青少年对他们的同龄人非常敏感[11,13-16]。值得注意的是，神经区域与 青春期的同伴影响，包括腹侧纹状体（VS）和腹侧前额叶皮层（VMPFC）， LPFC之前成熟。因此，青少年被唯一准备从旨在的社会干预中受益 适当的同伴会影响增强情绪调节功效的机制。 R21的目标 是与发展中的大脑，而不是反对它，以利用青少年奖励奖励相关 电路（VS，VMPFC），而不是LPFC来调节青少年的情绪。我们将管理一本小说 功能性磁共振成像（fMRI）期间的范式检查青少年（n = 50）和 当朋友向他们提供时，成人（n = 50）在下调负面影响方面更有效 与单独重新解释刺激相比，负面刺激的重新解释（即社会重新评估） （即认知重新评估）[12]。具体来说，我们将调查社会重新评估是否更有效 在青少年和成年人的下调负面影响下，比认知重新评估的持久性更长（AIM 1）。我们假设社会重新评估将比认知重新评估更有效和持久 两组，但是鉴于青少年对同龄人的敏感性的提高，这种影响将更大。 此外，我们将确定支持社会与认知重新评估的神经机制 表征与年龄相关的这些机制的差异（AIM 2）。我们将专注于检查激活 杏仁核，LPFC，VS和VMPFC，以及这些区域之间的功能连接。我们 假设LPFC-Amygdala连接将支持认知重新评估，这将在 成人与青少年，而VS-Amygdala和VMPFC-Amygdala连接将支持社交 重新评估。尽管VS-Amygdala连通性在青少年中可能比成年人更强，但VMPFC- 可能没有杏仁核连接性在青春期仍在发展[21,76]。我们 预计社会重新评估将对杏仁核具有更大的变革性和更长的影响 基于负面刺激的表示，特别是在青少年中，并将使用表示相似性 分析以检验该假设。研究社会重新评估的疗效和神经基础 青少年与成年人是促进我们对社会环境如何形成的理解的重要步骤 情绪调节神经发育，目的是改善青少年健康并奠定基础 积极的情感福祉到成年。