Development of Layer Specific FMRI for Clinical Scanners

临床扫描仪层特异性 FMRI 的开发

• 批准号: 10589648
• 负责人: Luis Hernandez-Garcia
• 金额: $ 39.06万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2025-09-19
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10589648
• 关键词: 3-Dimensional; Animals; Area; Blood; Blood Vessels; Blood Volume; Brain; Clinical; Confocal Microscopy; Data; Development; Diameter; Electrodes; Fourier Transform; Functional Imaging; Functional Magnetic Resonance Imaging; Goals; Hand; Hospitals; Human; Image; Institution; Literature; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methods; Movement; Neurosciences; Noise; Operative Surgical Procedures; Output; Pattern; Physiologic pulse; Psychiatry; Public Health; Research; Resolution; Respiration; Sampling; Scanning; Scheme; Series; Signal Transduction; Source; Specificity; Structure; Techniques; Technology; Testing; Time; Tissues; Training; Translating; Work; contrast imaging; imaging modality; implantation; improved; innovation; interest; novel; preservation; prevent; spatiotemporal; stem; temporal measurement; time use; tool

Summary Layer Specific FMRI is a new and exciting tool to probe mesoscale brain networks non-invasively, without the need for invasive surgical procedures, such as electrode implantation, or confocal microscopy. Recent work has demonstrated the Layer Specific FMRI can identify both the columnar, as well as layer specific structure of a network. While the field of Layer Specific FMRI is dominated by “ultra-high” field MRI scanners (7T and above), it is still extremely challenging to achieve those results in 3T scanners because of their reduced signal:noise ratio (SNR). The need for ultra-high field scanners stems from the requirement of extremely small voxels for layer specific FMRI, which translates into a dramatic loss of SNR. This need for ultra high field scanners means that much of it has to be carried out on small animals, and human work in this area is limited to a few select institutions. The goal of this proposal is to develop the technology needed to make layer specific FMRI feasible at 3T scanners, common in most research institutions. Our proposed strategy is to improve SNR efficiency and reduce scan time by using a reduced field of view, 3D read-out in tandem with a new positive vascular contrast imaging method based on Velocity Selective pulses to collect arterial blood volume weighted images much faster. At the same time, we will also aim to reduce the noise of the measurement by an efficient echo correction technique.

概括 层特定的fMRI是一种新的令人兴奋的工具，可无创地探测中尺度脑网络， 无需侵入性手术程序，例如电极植入或共焦 显微镜。最近的工作表明，特定fMRI层可以识别 柱状以及网络的图层特定结构。而特定fMRI的字段 由“超高”场MRI扫描仪（7T及以上）主导，它仍然非常挑战 由于信号的减少：噪声比（SNR），因此在3T扫描仪中获得这些结果。 需要超高的野外扫描仪，距离极小体素的需求 特定的fMRI，转化为SNR的巨大损失。 这种对超高现场扫描仪的需求意味着必须在小型上进行大部分 动物以及该地区的人工工作仅限于一些精选的机构。目标的目标 建议是开发在3T扫描仪中可行的特定层fMRI所需的技术， 在大多数研究机构中很常见。我们提出的策略是提高SNR效率和 通过使用降低的视场减少扫描时间，并以新的正面读取3D读出 基于速度选择性脉冲的血管对比成像方法收集动脉血液 体积加权图像更快。同时，我们还将降低 通过有效的回声校正技术进行测量。