Neuroinflammation, Neuronal IL-1R1, and Behavior

神经炎症、神经元 IL-1R1 和行为

基本信息

批准号：
10586078
负责人：
Ning Quan
金额：
$ 34.22万
依托单位：
FLORIDA ATLANTIC UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10586078
关键词：
Acute Brain Injuries Adhesions Aging Anatomy Animal Model Atlases Behavior Behavioral Binding Brain Brain Mapping CNS autoimmune disease Cells Central Nervous System Diseases Chronic Data Development Disease Epilepsy Etiology Genetic Polymorphism Genetic Predisposition to Disease Glutamates Hippocampus Human Genetics IL1R1 gene Impaired cognition Inflammatory Interleukin-1 Interleukin-1 Receptors Knock-in Knock-in Mouse Label Light Link LoxP-flanked allele Maps Mediating Memory impairment Mental disorders Methods Microscopy Modeling Molecular Mood Disorders Mus Nervous System Neurodegenerative Disorders Neurologic Neurons Neurotransmitters Pathogenesis Pathology Pathway interactions Predisposition Protein Tyrosine Phosphatase Psychopathology Reporter Role Short-Term Memory Signal Pathway Signal Transduction Stress Synapses System Tracer Withdrawal behavioral study cell type comorbidity cytokine design fighting mRNA Expression neuroinflammation neuropathology neuroregulation novel prevent protein expression psychologic receptive field receptor response single cell sequencing social synaptogenesis

项目摘要

Project Summary Neuroinflammation is a significant contributor to most CNS disorders including neurodegenerative diseases and psychological disorders. A hallmark of neuroinflammation is the increased expression of the proinflammatory cytokine interleukin-1 (IL-1) in the brain. How IL-1 causes neuro- and psycho- pathologies is poorly understood. We have recently discovered that the receptor for IL-1, IL-1R1, is expressed in specific sets of neurons in the brain. These neuronal IL-1R1s, nIL-1R1, modulate neuronal activity via non-canonical signaling pathways to alter neuronal function and circuit connectivity. This application is designed to: 1) map nIL-1R1 distribution in the brain, 2)demonstrate the involvement of nIL-1R1 in neuroinflammation induced behavioral deficits and neuropathology, and 3) elucidate the mechanisms of nIL-1R1 mediated neuromodulation.

项目摘要神经炎症是大多数CNS疾病（包括神经退行性）的重要贡献疾病和心理疾病。神经炎症的标志是增加的表达大脑中促炎性细胞因子白细胞素1（IL-1）。 IL-1如何引起神经和心理病理学知之甚少。我们最近发现IL-1，IL-1R1的受体是以大脑中的特定神经元组表示。这些神经元IL-1R1，NIL-1R1，调节神经元通过非规范信号通路的活性，以改变神经元功能和电路连接。这应用设计为：1）MAP NIL-1R1在大脑中的分布，2）证明 NIL-1R1在神经炎症中引起的行为缺陷和神经病理学，3）阐明 NIL-1R1的机理介导的神经调节。