DEVELOPMENTAL RESEARCH PROGRAM

发展研究计划

• 批准号: 7976019
• 负责人: ROBERT ZYGMUNT ORLOWSKI
• 金额: $ 9.11万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7976019
• 关键词: Budgets; Clinical; Collaborations; Core Facility; Development; Diagnosis; Disease; Eligibility Determination; Event; Fostering; Funding; Future; Goals; Hematologic Neoplasms; Institution; Methods; Mission; Monitor; Multiple Myeloma; Peer Review; Procedures; Process; Program Research Project Grants; Program Reviews; Progress Reports; Reproduction spores; Request for Applications; Research; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Review Committee; Scientist; Seeds; Source; Specific qualifier value; Staging; Testing; Translational Research; United States National Institutes of Health; flexibility; innovation; interest; meetings; member; multidisciplinary; novel; novel strategies; prevent; programs

The Developmental Research Program (DRP) will provide seed funding to meritorious translational projects that have the potential for significantly advancing our ability to prevent, detect, diagnose, stage, or treat multiple myeloma. Project proposals will be selected in a rigorous, peer-reviewed, two-tiered process, starting with a once-yeariy request for applications that will be communicated to investigators at all three participafing institutions. In this first round, proposals will be limited to four pages, and required to assume the format of an NIH R01 applicafion, incorporafing specific aims, background and significance, preliminary studies, and research design and methods. These proposals will be reviewed by the DRP Director and Co- Director to identify those that meet the pre-specified eligibility criteria, and these will be invited to submit a full, ten-page applicafion, using the same format with the inclusion of a budget and justification. During this second fier, proposals will be reviewed by the DRP Review Committee, which will include Leaders and/or Co-Leaders of each of the SPORE Projects, Directors and/or Co-Directors of SPORE Cores, and at least four members of the External Scientific Advisory Board, and four members of the Internal Scientific Advisory Board. Up to four projects each year will be selected for funding and supported for one year, during which progress reports will be monitored every six months. Renewal of support may be possible for a second year, but will require the project to successfully compete with the next year's pool of proposals. Through this mechanism, the specific aims of the DRP are: 1. To support novel, highly translational research projects that take maximum advantage of the new research opportunities afforded by the SPORE; 2. To build and foster new collaborafions among scientists within SPOREs, or with scienfists outside the SPORE mechanism; and 3. To provide.scientific flexibility to the SPORE that will allow promofion of promising DRP projects to full Project status. Prior to the submission of this applicafion, the standard operating procedure outlined above was successfully tested, and led to the selection of several promising proposals to serve as examples of the types of projects that would be considered for support. Notably, these come from a diverse group of invesfigators interested in a variety of approaches with important translational implicafions, and support the future strength of the DRP.

发展研究计划（DRP）将为优秀的转化项目提供种子资金 有潜力显着提高我们预防、检测、诊断、分期或治疗的能力 多发性骨髓瘤。项目提案将通过严格的、同行评审的两级流程进行选择， 从每年一次的申请请求开始，该请求将传达给所有三个机构的调查人员 参与机构。在第一轮中，提案将限于四页，并且需要假设 NIH R01 申请的格式，包括具体目标、背景和意义、初步 研究、研究设计和方法。这些提案将由 DRP 主任和副主任审查 主任确定那些符合预先指定的资格标准的人，并邀请他们提交一份 完整的十页申请，使用相同的格式，包括预算和理由。在此期间 第二层，提案将由 DRP 审查委员会审查，其中包括领导人和/或 每个 SPORE 项目的联合领导者、SPORE 核心的董事和/或联合董事，并且至少 四名外部科学顾问委员会成员和四名内部科学顾问委员会成员 木板。每年最多选择四个项目进行资助并支持一年，在此期间 每六个月将监测一次进度报告。可能会在第二年续签支持， 但需要该项目成功地与明年的提案库竞争。通过这个 DRP 机制的具体目标是： 1. 支持新颖、高度转化的研究项目 最大限度地利用 SPORE 提供的新研究机会； 2. 构建和 促进 SPORE 内科学家之间或与 SPORE 外科学家之间的新合作 机制; 3. 为 SPORE 提供科学灵活性，以促进有前景的 DRP 项目达到完整项目状态。在提交本申请之前，标准操作程序 上述概述已成功测试，并导致选择了几个有前途的提案作为 将考虑支持的项目类型的示例。值得注意的是，这些来自不同的 对具有重要转化意义的各种方法感兴趣的研究小组，以及 支持DRP未来的实力。