Monitoring Disease in Lupus

监测狼疮疾病

基本信息

批准号：
10583454
负责人：
CHANDRA MOHAN
金额：
$ 54.2万
依托单位：
UNIVERSITY OF HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-03-08 至 2025-02-28
项目状态：
未结题

项目摘要

Lupus is a systemic autoimmune disease resulting in inflammation in multiple organ systems. The disease course is very variable and unpredictable. There is a definite clinical need for better biomarkers for monitoring this disease, particularly renal disease. The current tools available for monitoring lupus and end-organ involvement are not optimal. More reliable tools that detect early disease are warranted. Early detection and prompt treatment can have significant impact on morbidity and disease course. There is also a need for better biomarkers that can be used to assess treatment response in clinical trials. Our completed studies using a couple of targeted proteomic platforms have uncovered several serum or urine proteins that are elevated in lupus patients with elevated SLE disease activity index. From our completed studies, and newly proposed targeted proteomic screens, we will assemble a panel of about 40 serum or urine biomarkers. We will ascertain if these novel biomarkers have the potential to identify lupus patients with active renal disease, monitor disease activity serially, predict treatment response or project long-term outcome in these patients. Besides their biomarker potential, the protein markers examined in this proposal may also constitute therapeutic targets as they exhibit a variety of interesting functional attributes. Better non-invasive biomarkers can significantly improve disease management in patients with lupus nephritis.

狼疮是一种全身性自身免疫性疾病，导致多个器官系统炎症。疾病课程是非常多变且不可预测的。临床确实需要更好的生物标志物进行监测这种疾病，特别是肾脏疾病。当前可用于监测狼疮和终末器官的工具参与度并不是最佳的。需要更可靠的工具来检测早期疾病。及早发现和及时治疗可对发病率和病程产生重大影响。还需要更好的可用于评估临床试验中治疗反应的生物标志物。我们完成的研究使用几个靶向蛋白质组平台发现了几种血清或尿液蛋白质在 SLE 疾病活动指数升高的狼疮患者。根据我们完成的研究和新提出的通过靶向蛋白质组筛选，我们将组装一组约 40 种血清或尿液生物标志物。我们将确定如果这些新的生物标志物有潜力识别患有活动性肾病的狼疮患者，则监测疾病连续活动，预测这些患者的治疗反应或预测长期结果。除了他们的生物标志物潜力，本提案中检查的蛋白质标志物也可能构成治疗靶点，如它们表现出各种有趣的功能属性。更好的非侵入性生物标志物可以显着改善狼疮性肾炎患者的疾病管理。