Foreboding Lupus Nephritis in Minority Woman

少数民族妇女患狼疮性肾炎的预兆

• 批准号: 8329662
• 负责人: CHANDRA MOHAN
• 金额: $ 44.24万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8329662
• 关键词: Address; African American; Antibodies; Antineutrophil Cytoplasmic Antibodies; Biological Assay; Biological Markers; Biopsy; Clinical Management; Collection; Complex; Cross-Sectional Studies; Disease; Disease Outcome; Disease Progression; Early Diagnosis; End stage renal failure; Experimental Models; Flare; Focal Segmental Glomerulosclerosis; Frequencies; Gel; Genetic; Glomerulonephritis; Goals; Grant; Hispanics; Human; Incidence; Individual; Inflammation; Kidney; Kidney Diseases; Knowledge; Laboratories; Longitudinal Studies; Lupus; Lupus Nephritis; Mass Spectrum Analysis; Mediating; Minority; Monitor; Morbidity - disease rate; Mus; Nephritis; P-Selectin; Pathology; Patients; Peptide Hydrolases; Predictive Value; Prostaglandin D2; Prostaglandin-Endoperoxide Synthase; Proteinuria; Proteome; Proteomics; Renin; Rheumatoid Arthritis; Role; Sampling; Serum; Specificity; Superoxide Dismutase; Systemic Lupus Erythematosus; Technology; Urine; Vascular Cell Adhesion Molecule-1; Woman; cohort; cost effective; disease diagnosis; follow-up; mortality; mouse model; novel; response; routine practice; systemic autoimmune disease; urinary

Lupus is a systemic autoimmune disease that is complex in genetics and its immunological origins. Renal disease is a leading cause of morbidity and mortality in lupus, particularly among minority women. Although serial renal biopsies may be ideal in closely monitoring the progression of lupus nephritis, it may not be practical or feasible. Hence, the long-term goal of these studies is to identify potential biomarkers that may be of use in monitoring the progression of renal disease in lupus. Using different proteomic approaches, we have uncovered several molecules that appear in the urine during antibody-mediated nephritis. Our completed cross-sectional studies have helped uncover 6 potential biomarker candidates in the urine of mice and patients with lupus. In this proposal, we will study a cohort of lupus patients, 90% of whom are minority individuals, in a longitudinal fashion in order to determine if any of the urinary biomarker candidates might be better at predicting flares, severe histological nephritis, or end stage renal disease, compared to currently used laboratory yardsticks. In addition, we propose to establish the specificity of these biomarkers for lupus nephritis, as well as other causes of proteinuria and nephritis. Given the high incidence of end stage renal disease in lupus, early diagnosis and prompt treatment is absolutely essential. Identification of more predictive biomarkers in the urine of these patients could have a profound impact on the clinical management of lupus nephritis.

狼疮是一种系统性自身免疫性疾病，其遗传学及其免疫学起源非常复杂。肾 该疾病是狼疮发病和死亡的主要原因，特别是在少数族裔妇女中。 尽管连续肾活检可能是密切监测狼疮性肾炎进展的理想选择，但它可能 不切实际或不可行。因此，这些研究的长期目标是确定潜在的生物标志物 可用于监测狼疮肾病的进展。 使用不同的蛋白质组学方法，我们发现了尿液中出现的几种分子 抗体介导的肾炎。我们完成的横断面研究帮助发现了 6 种潜力 小鼠和狼疮患者尿液中的候选生物标志物。在本提案中，我们将研究一组 狼疮患者，其中 90% 是少数族裔，以纵向方式确定是否有任何狼疮患者 的候选尿液生物标志物可能能够更好地预测耀斑、严重组织学肾炎或终末期肾病 与目前使用的实验室标准相比，肾病阶段。此外，我们建议设立 这些生物标志物对狼疮性肾炎以及蛋白尿和肾炎的其他原因的特异性。 鉴于狼疮终末期肾病的高发病率，早期诊断和及时治疗至关重要 绝对必要。在这些患者的尿液中鉴定出更具预测性的生物标志物可能有助于 对狼疮性肾炎的临床治疗产生深远影响。