Using pre-pandemic baseline data in people with and without PTSD to study effects of the COVID-19 pandemic on mental health and brain emotion circuits

使用患有和不患有 PTSD 的人的大流行前基线数据来研究 COVID-19 大流行对心理健康和大脑情绪回路的影响

• 批准号: 10583520
• 负责人: Xin Wang
• 金额: $ 18.57万
• 依托单位: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-03 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10583520
• 关键词: Address; Adult; Affect; Analysis of Variance; Attention; Behavioral; Brain; Brain region; COVID-19 pandemic; COVID-19 pandemic effects; COVID-19 patient; Communities; Coronavirus Infections; Data; Development; Diagnosis; Emotions; Face; Foundations; Fright; Functional disorder; Impairment; Interview; Investigation; Life Stress; Longitudinal Studies; Measures; Mediating; Mediation; Mental Health; Mental association; Mental disorders; Methods; Middle frontal gyrus structure; Patients; Persons; Post-Traumatic Stress Disorders; Reaction; Regression Analysis; Research; Resolution; Seminal; Severities; Social isolation; Stress; Structure; Surveys; Survivors; Symptoms; System; Testing; Theoretical model; Thick; Time; Trauma; Work; associated symptom; brain based; case control; coronavirus disease; effective therapy; emotion dysregulation; emotional adjustment; emotional experience; emotional trauma; experience; longitudinal analysis; neuroimaging; pandemic disease; pandemic impact; post-trauma; post-traumatic symptoms; pre-pandemic; prospective; social relationships

Project Summary The coronavirus disease 2019 (COVID-19) pandemic has caused fear, stress, and emotional trauma due to loss of lives, widespread sickness, extended social isolation, and financial insecurity. Pandemic-related experiences can lead to post-traumatic stress symptoms (PTSS) and other mental health problems and can exacerbate pre-existing mental health conditions. Neuroimaging studies suggest that PTSS and other mental health symptoms involve emotion dysregulation that emerges from functional and structural alterations of brain emotion circuits. Extending pre-pandemic neuroimaging research on PTSD development, this application proposes to use neuroimaging and behavioral data from adult pre-pandemic trauma survivors, who subsequently developed or did not develop PTSD prior to the pandemic, as baselines from which to longitudinally study pandemic effects on PTSS and associated brain emotion systems in these same subjects. Pandemic emotional experiences associated with, e.g., coronavirus infection, social isolation, and financial insecurity will be analyzed with respect to pre- vs. peri-pandemic changes in PTSS, other mental health symptoms, brain structure, and brain activation to fear emotion related tasks. Peri-pandemic symptoms and brain measures will also be compared in pre-pandemic PTSD vs. non-PTSD groups to test if these groups are being affected in similar or different ways. Comparison of pre- vs. peri- pandemic data in the same subjects will optimize resolution of how the pandemic is affecting mental health and brain function and structure and of how the pandemic is affecting people with different pre-pandemic PTSD dispositions. The results will identify ongoing mental health and brain effects of this pandemic and help prepare strategies to deal with its aftermath.

项目概要 2019 年冠状病毒病 (COVID-19) 大流行造成了恐惧、压力和情感创伤，原因是 造成生命损失、疾病蔓延、社会隔离时间延长和经济不安全。疫情相关 经历可能导致创伤后应激症状（PTSS）和其他心理健康问题，并且可能 加剧已有的心理健康状况。神经影像学研究表明 PTSS 和其他精神疾病 健康症状涉及因大脑功能和结构改变而出现的情绪失调 情感回路。该应用程序扩展了大流行前对 PTSD 发展的神经影像学研究 建议使用大流行前创伤幸存者的神经影像和行为数据，他们 在大流行之前随后出现或未出现 PTSD，作为基线 纵向研究流行病对这些相同受试者的 PTSS 和相关大脑情绪系统的影响。 与冠状病毒感染、社会隔离和财务等相关的流行病情绪体验 将根据 PTSS 和其他心理健康方面的大流行前与大流行期间的变化来分析不安全感 症状、大脑结构以及恐惧情绪相关任务的大脑激活。大流行期间的症状和 还将对大流行前 PTSD 组与非 PTSD 组的大脑测量进行比较，以测试这些组是否 以类似或不同的方式受到影响。对同一受试者的大流行前与大流行期间数据进行比较将 优化解决大流行如何影响心理健康和大脑功能和结构以及如何影响心理健康和大脑功能和结构的问题 这场流行病正在影响具有不同流行前创伤后应激障碍倾向的人。结果将确定 这种流行病对心理健康和大脑的持续影响，并帮助制定应对其后果的策略。