Using pre-pandemic baseline data in people with and without PTSD to study effects of the COVID-19 pandemic on mental health and brain emotion circuits

使用患有和不患有 PTSD 的人的大流行前基线数据来研究 COVID-19 大流行对心理健康和大脑情绪回路的影响

• 批准号: 10583520
• 负责人: Xin Wang
• 金额: $ 18.57万
• 依托单位: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-03 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10583520
• 关键词: Address; Adult; Affect; Analysis of Variance; Attention; Behavioral; Brain; Brain region; COVID-19 pandemic; COVID-19 pandemic effects; COVID-19 patient; Communities; Coronavirus Infections; Data; Development; Diagnosis; Emotions; Face; Foundations; Fright; Functional disorder; Impairment; Interview; Investigation; Life Stress; Longitudinal Studies; Measures; Mediating; Mediation; Mental Health; Mental association; Mental disorders; Methods; Middle frontal gyrus structure; Patients; Persons; Post-Traumatic Stress Disorders; Reaction; Regression Analysis; Research; Resolution; Seminal; Severities; Social isolation; Stress; Structure; Surveys; Survivors; Symptoms; System; Testing; Theoretical model; Thick; Time; Trauma; Work; associated symptom; brain based; case control; coronavirus disease; effective therapy; emotion dysregulation; emotional adjustment; emotional experience; emotional trauma; experience; longitudinal analysis; neuroimaging; pandemic disease; pandemic impact; post-trauma; post-traumatic symptoms; pre-pandemic; prospective; social relationships

Project Summary The coronavirus disease 2019 (COVID-19) pandemic has caused fear, stress, and emotional trauma due to loss of lives, widespread sickness, extended social isolation, and financial insecurity. Pandemic-related experiences can lead to post-traumatic stress symptoms (PTSS) and other mental health problems and can exacerbate pre-existing mental health conditions. Neuroimaging studies suggest that PTSS and other mental health symptoms involve emotion dysregulation that emerges from functional and structural alterations of brain emotion circuits. Extending pre-pandemic neuroimaging research on PTSD development, this application proposes to use neuroimaging and behavioral data from adult pre-pandemic trauma survivors, who subsequently developed or did not develop PTSD prior to the pandemic, as baselines from which to longitudinally study pandemic effects on PTSS and associated brain emotion systems in these same subjects. Pandemic emotional experiences associated with, e.g., coronavirus infection, social isolation, and financial insecurity will be analyzed with respect to pre- vs. peri-pandemic changes in PTSS, other mental health symptoms, brain structure, and brain activation to fear emotion related tasks. Peri-pandemic symptoms and brain measures will also be compared in pre-pandemic PTSD vs. non-PTSD groups to test if these groups are being affected in similar or different ways. Comparison of pre- vs. peri- pandemic data in the same subjects will optimize resolution of how the pandemic is affecting mental health and brain function and structure and of how the pandemic is affecting people with different pre-pandemic PTSD dispositions. The results will identify ongoing mental health and brain effects of this pandemic and help prepare strategies to deal with its aftermath.

项目摘要 2019年冠状病毒病（COVID-19）大流行引起了恐惧，压力和情绪创伤 丧生，广泛的疾病，扩展的社会隔离和财务不安全感。大流行有关 经验会导致创伤后压力症状（PTS）和其他心理健康问题，并且可以 恶化的精神健康状况。神经影像学研究表明，PTSS和其他精神 健康症状涉及情绪失调，这些失调来自大脑的功能和结构改变 情绪电路。扩展了有关PTSD开发的流行前神经影像学研究，该应用 建议使用成人大流行前创伤幸存者的神经影像学和行为数据，谁 随后在大流行之前开发或不发展PTSD，作为基准 纵向研究对这些受试者中PTSS和相关大脑情绪系统的大流行作用。 与冠状病毒感染，社会隔离和财务相关的大流行情感经历 将在PTSS，其他心理健康的PRE与大群变化方面分析不安全感 症状，大脑结构和大脑激活与情绪相关的任务。流血症状和 还将在研究前PTSD与非PTSD组中比较脑测量，以测试这些组是否是 以类似或不同的方式受到影响。在同一受试者中比较Pre-er-大流行数据的比较 优化大流行如何影响心理健康，大脑功能和结构以及如何解决的解决方案 大流行正在影响患有不同前PTSD处置的人。结果将确定 这种大流行的持续心理健康和大脑影响，并有助于准备应对其后果的策略。