Social, Developmental and Epidemiology of Alcohol Use Disorders

酒精使用障碍的社会、发育和流行病学

基本信息

批准号：
10581566
负责人：
KENNETH SEEDMAN KENDLER
金额：
$ 49.73万
依托单位：
VIRGINIA COMMONWEALTH UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-15 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10581566
关键词：
Academic achievement Acculturation Acquaintances Address Affect Age Alcohols Birth Cardiovascular system Caring Childhood Clinical Communities Couples Data Data Sources Development Disease Economics Environmental Risk Factor Epidemiology Etiology Extended Family Family Funding Generations Genetic Genetic Models Genetic Risk Geographic Locations Geography Goals Health Heterogeneity Hospitals Hypertension Immigrant Immigration Individual International Classification of Disease Codes Intervention Laws Marital Relationships Marital Status Marriage Mediating Mediator Medical Mental Depression Mental disorders Methodology Methods Morbidity - disease rate Natural experiment Nature Nuclear Family Obesity Onset of illness Outcome Parents Partner in relationship Pathway interactions Pattern Performance Personality Pharmaceutical Preparations Phenotype Policies Population Prevention Primary Care Process Productivity Psychological Models Psychopathology Randomized Records Recurrence Refugees Registries Research Resources Risk Risk Assessment Risk Factors Role Sampling Sex Differences Siblings Social outcome Specialist Statistical Methods Structural Models Sweden Testing Typology Universities Virginia Woman Work alcohol consequences alcohol epidemiology alcohol exposure alcohol risk alcohol use disorder causal model comorbidity contagion data registry deprivation design disorder risk epidemiological model genetic analysis genetic pedigree grandchild high risk improved indexing insight medical complication member men offspring protective factors psychiatric comorbidity psychosocial residence sex social social model sociodemographic factors transmission process

项目摘要

Project Summary We seek, in this revision of our renewal application, to build on the findings of our productive first project period that was focused on advancing our understanding of risk and protective factors for, and the consequences of, Alcohol Use Disorder (AUD). In the next funding period, we will apply our epidemiological and methodological expertise to examine the following facets of AUD: the etiology and consequences of its phenotypic heterogeneity; the influence of specific causal factors; the nature and etiology of the medical consequences of AUD; the transmission of AUD within marital pairs, nuclear families and extended pedigrees and the impact of acculturation on risk for AUD in various immigrant groups. These goals all utilize the wide range of data available from multiple nationwide data sources in Sweden on 11.8 million men and women, 26% of whom are 1st- or 2nd-generation immigrants. These data are of unparalleled completeness and depth and have recently been expanded to include a Swedish primary care registry (PCR) created by our team. Our first specific aim seeks to address the important problem of the heterogeneity of AUD by applying latent class analysis to develop an optimal typology of AUD in all affected cases in Sweden. We will then validate this using a split-half design and determine how these subtypes are associated with key risk factors and whether subtypes are differentially associated with psychosocial and medical sequelae of AUD. Our second aim uses standard and newly developed methods of causal inference to examine the impact of poor academic achievement on AUD risk, and evaluate, in two different ways, promising models for the psychological transmission of AUD within families. We will here utilize a range of natural experiments available in Swedish registry data. Our third aim will capitalize on the newly available PCR and other medical registers to determine the temporal, genetic, and environmental relationships between AUD and both classical alcohol-related medical complications and common medical morbidities such as cardiovascular illness, hypertension and obesity. Our fourth aim will explore the transmission of AUD risk within large pedigrees and marital relationships using three major strategies: advanced SEM methods; exploration within three-generation pedigrees of features of second generation members who do versus do not transmit AUD to the third generation; and study of the multiple ways in which various marital outcomes can impact on the risk for and the course of AUD. Our final aim will examine, among immigrants to Sweden, how rates of AUD are modified by acculturation. Applying the expertise of our research groups at Virginia Commonwealth and Lund University in AUD research, social and genetic epidemiology, and causal modeling to a uniquely powerful sample, we will be able to improve risk assessment and offer insight for promising prevention/intervention targets for AUD and its consequences.

项目摘要在对我们续订申请的这一修订中，我们寻求基于我们富有成效的第一项目时期的发现这重点是推进我们对风险和保护因素的理解，以及酒精使用障碍（AUD）。在下一个资金期间，我们将应用流行病学和方法论专业知识来检查AUD的以下方面：其表型的病因和后果异质性；特定因果因素的影响；医学后果的性质和病因 aud;在婚姻对，核心家庭和延长的血统内传播AUD的影响以及各个移民群体中AUD风险的适应性。这些目标都利用了广泛的数据瑞典的多个全国数据来源可从1,180万男女获得，其中26％是第一代或第二代移民。这些数据是无与伦比的完整性和深度，最近具有被扩展到包括我们团队创建的瑞典初级保健注册表（PCR）。我们的第一个特定目标试图通过将潜在类别分析应用于AUD的异质性的重要问题在瑞典所有受影响的情况下，开发出AUD的最佳类型。然后，我们将使用半分裂来验证这一点设计并确定这些亚型如何与关键危险因素相关联以及亚型是否与与AUD的社会心理和医学后遗症有关。我们的第二个目标使用标准和新开发的因果推断方法，以检查不良学术成就对AUD的影响风险，并以两种不同的方式评估AUD内部心理传播的有希望的模型家庭。我们将在这里利用瑞典注册表数据中可用的一系列自然实验。我们的第三个目标将利用新的PCR和其他医疗记录来确定时间，遗传和 AUD与经典酒精相关的医疗并发症以及常见的医疗病患者，例如心血管疾病，高血压和肥胖症。我们的第四个目标使用三个主要的策略：高级SEM方法；第二代特征的三代探索与之相对于第三代的一代成员不要将AUD传输到第三代；并研究倍数各种婚姻结果可能会影响AUD风险和进程的方式。我们的最终目标在瑞典的移民中检查AUD率如何通过适应来改变。应用我们在弗吉尼亚州联邦和隆德大学的研究小组的专业知识在AUD研究，社会和遗传流行病学和为独特强大样本的因果建模，我们将能够改善风险评估并提供有希望的预防/干预目标及其后果的见解。

项目成果

期刊论文数量（50）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Alcohol use disorder and divorce: evidence for a genetic correlation in a population-based Swedish sample.

DOI：
10.1111/add.13719
发表时间：
2017-04
期刊：
Addiction (Abingdon, England)
影响因子：
0
作者：
Salvatore JE;Larsson Lönn S;Sundquist J;Lichtenstein P;Sundquist K;Kendler KS
通讯作者：
Kendler KS

The rearing environment and the risk for alcohol use disorder: a Swedish national high-risk home-reared v. adopted co-sibling control study.

DOI：
10.1017/s0033291720000963
发表时间：
2021-10
期刊：
Psychological medicine
影响因子：
6.9
作者：
Kendler KS;Ohlsson H;Sundquist J;Sundquist K
通讯作者：
Sundquist K

Geographic proximity is associated with transmission of suicidal behaviour among siblings.

地理位置的接近与兄弟姐妹之间自杀行为的传播有关。

DOI：
10.1111/acps.13040
发表时间：
2019
期刊：
Acta psychiatrica Scandinavica
影响因子：
6.7
作者：
Edwards,AC;Ohlsson,H;Mościcki,EK;Sundquist,J;Sundquist,K;Kendler,KS
通讯作者：
Kendler,KS

Death of parent, sibling, spouse, and child in a Swedish national sample and risk of subsequent stress reaction, major depression, alcohol-use disorder, and drug-use disorder.

DOI：
10.1017/s0033291723000570
发表时间：
2023-11
期刊：
PSYCHOLOGICAL MEDICINE
影响因子：
6.9
作者：
Kendler, Kenneth S.;Lonn, Sara L.;Sundquist, Jan;Sundquist, Kristina
通讯作者：
Sundquist, Kristina

Parental alcohol use disorder and offspring marital outcomes.

父母酒精使用障碍和后代婚姻结果。

DOI：
10.1111/add.14405
发表时间：
2019
期刊：
Addiction (Abingdon, England)
影响因子：
0
作者：
Salvatore,JessicaE;LarssonLönn,Sara;Long,ElizabethC;Sundquist,Jan;Kendler,KennethS;Sundquist,Kristina;Edwards,AlexisC
通讯作者：
Edwards,AlexisC