Arkansas Center for Food Allergy Research (ArCOFAR)

阿肯色州食物过敏研究中心 (ArCOFAR)

• 批准号: 10581677
• 负责人: Stacie M Jones
• 金额: $ 23.5万
• 依托单位: ARKANSAS CHILDREN'S HOSPITAL RES INST
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-03 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10581677
• 关键词: Achievement; Address; Adult; Advanced Development; Advocacy; Affect; Allergic; Area; Arkansas; Awareness; Birth; Characteristics; Child; Child Health; Clinical; Clinical Research; Clinical Skills; Clinical Trials; Cohort Studies; Collaborations; Communities; Development; Disease; Education; Enrollment; Faculty; Faculty Recruitment; Food; Food Hypersensitivity; Foundations; Funding; Future; Genetic study; Geographic Locations; Geography; Goals; Historical Cohort Studies; Immunotherapeutic agent; Individual; Industry; Institution; Interdisciplinary Study; International; Investigation; Juglans; Knowledge; Leadership; Life; Link; Longitudinal Studies; Low income; Measurable; Mentors; Mission; National Institute of Allergy and Infectious Disease; Natural History; Nut Hypersensitivity; Outcome; Participant; Patients; Pediatric Hospitals; Population; Population Heterogeneity; Population Research; Positioning Attribute; Prevalence; Prevention; Privatization; Productivity; Reaction; Recruitment Activity; Research; Research Personnel; Resources; Rural; Scientist; Seminal; Shapes; Site; Testing; Therapeutic; Therapeutic Trials; Translational Research; United States National Institutes of Health; Work; career; career development; clinical care; cohort; design; effective therapy; experience; faculty mentor; improved; industry partner; innovation; medically underserved; novel; oral immunotherapy; programs; racial diversity; recruit; success; therapeutically effective

PROJECT SUMMARY Food allergy is a disease of global impact associated with life-threatening reactions, increasing prevalence, and limited options for treatment and prevention. Despite significant research advances, many remaining questions must be addressed before global implementation of impactful therapeutic and prevention options for patients affected by food allergy can be realized. The Consortium for Food Allergy Research (CoFAR) was formed to address these unresolved questions through its collaborative research network of Clinical Research Units (CRU) with experience and expertise in food allergy clinical trials. To this end, the Arkansas Center for Food Allergy Research (ArCOFAR) builds on a >30 year foundation of excellence, expertise, and leadership in food allergy and is prepared to immediately address the overarching program goals of CoFAR. The ArCOFAR site is ideally-positioned to function as a CoFAR CRU through contribution of our extensive research experience and by capitalizing on our population's unique geographic and patient demographic characteristics. Our efforts will be directed by the central hypothesis that ArCOFAR will enable the participation of diverse groups of food allergic individuals in expertly designed, innovative clinical trials of the highest quality and scientific value. Our overarching goal is to provide a unique research platform to measurably improve the lives of children and adults with food allergy. This goal will be accomplished by the design and implementation of innovative clinical studies and therapeutic trials via high-quality, high-impact research collaboration. Our hypothesis will be tested by executing four specific aims: 1) Leverage established expertise in food allergy research as a platform to expand clinical trials development in immunotherapeutics through integrated research efforts with other CoFAR CRUs; 2) Apply institutional and community resources to expand ArCOFAR CRU capacity for population-based research in food allergy, including participation in birth cohort and longitudinal outcome studies; 3) Link current inter- and intra-institutional resources to broaden the scope of clinical research participation to include a more diverse population of food allergic patients; 4) Promote career development of new and early career food allergy researchers through active recruiting and mentoring of new faculty and linking established programmatic and network resources. In addition, our cutting-edge clinical trial of walnut oral immunotherapy will address an unmet need in management of tree nut allergy. Further, ArCOFAR's multi-disciplinary team with established expertise and international leadership in food allergy clinical trials, will expand clinical research through the development and testing of novel immunotherapeutics and implementation of cohort studies, while providing mentoring and career development opportunities to early and new career investigators. The outcome of this proposal will be to improve the health of children and adults with food allergy in Arkansas and beyond while advancing the mission of CoFAR to fundamentally change the field of food allergy.

项目摘要 食物过敏是一种与威胁生命的反应相关的全球影响疾病，增加了患病率， 以及有限的治疗和预防选择。尽管有重大的研究进展，但仍有许多 在全球实施有影响力的治疗和预防方案之前，必须解决问题 可以实现受食物过敏影响的患者。食品过敏研究联盟（Cofar）是 通过其临床研究的协作研究网络来解决这些未解决的问题 单位（CRU）具有食物过敏临床试验方面的经验和专业知识。为此，阿肯色州的中心 食品过敏研究（Arcofar）建立在卓越，专业和领导力的30年基金会基础上 在食物过敏中，准备立即解决科法尔的总体计划目标。这 Arcofar网站是理想位置的，可以通过我们的广泛研究的贡献作为Cofar Cru起作用 经验并通过利用我们人口独特的地理和患者人口特征。 我们的努力将由中心假设指导，即Arcofar将使各种参与 最高质量的专业设计的创新临床试验中的食物过敏者组 和科学价值。我们的总体目标是提供一个独特的研究平台，以衡量改善 食物过敏的儿童和成人的生活。这个目标将通过设计和 通过高质量的高质量研究实施创新的临床研究和治疗试验 合作。我们的假设将通过执行四个具体目标来检验：1）利用已建立的专业知识 在食品过敏研究中，作为扩大免疫治疗剂临床试验开发的平台 与其他Cofar Crus的整合研究工作； 2）应用机构和社区资源来扩展 用于基于人群的食物过敏研究的Arcofar CRU能力，包括参与出生队列 和纵向结果研究； 3）将当前和内部机构内部资源联系起来，以扩大 临床研究参与包括更多种群的食物过敏患者； 4）促进职业 通过积极招募和指导新的和早期的职业食品过敏研究人员开发 教师和链接已建立的程序化和网络资源。此外，我们的尖端临床试验 核桃口服免疫疗法将满足对树坚果过敏的治疗的需求。更远， Arcofar的多学科团队拥有既定的食品过敏方面的专业知识和国际领导 临床试验将通过开发和测试新型免疫疗法扩大临床研究 并实施队列研究，同时提供指导和职业发展机会 和新的职业调查员。该提议的结果将是改善儿童和成人的健康 在阿肯色州及以后的食物过敏的同时推进科法尔的使命，从根本上改变 食物过敏领域。