Nutrient-dependent regulation of neural stem cell proliferation and neural circuit formation

神经干细胞增殖和神经回路形成的营养依赖性调节

• 批准号: 10581868
• 负责人: Sarah Elizabeth Siegrist
• 金额: $ 1.64万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10581868
• 关键词: Alzheimer' s Disease; Animals; Award; Biological Models; Brain; Cells; Development; Diet; Drosophila genus; Drosophila melanogaster; Funding; Genetic; Healthcare Systems; Human; Humidity; Incubators; Laboratories; Malignant Neoplasms; Microcephaly; Molecular; Neurodegenerative Disorders; Neurodevelopmental Disorder; Neurons; Nutrient; Research; Societies; Staging; Temperature; autism spectrum disorder; cost; dietary; experimental study; nerve stem cell; neural circuit; neuronal circuitry; neuroregulation; response; stem cell proliferation

PROJECT SUMMARY We are seeking to acquire supplemental funds to support the purchase of an incubator that will be used in our research that is currently funded by a R35 award. Our current R35 is aimed at uncovering genetic and molecular mechanisms that regulate neural stem cell proliferation decisions in response to dietary nutrient availability and the nutrient-regulated neuronal circuitry that controls these decisions. We use Drosophila melanogaster as a model system. In order to use Drosophila in a laboratory setting, a temperature, humidity, and light/dark cycle controlled incubator is needed to house the animals and for developmental staging experiments.

项目摘要 我们正在寻求获取补充资金，以支持购买将要购买的孵化器 目前由R35奖资助的研究中使用。我们目前的R35针对 发现调节神经干细胞增殖的遗传和分子机制 响应饮食营养的可用性和养分调节的神经元电路的决定 控制这些决定。我们将果蝇Melanogaster用作模型系统。为了 在实验室环境中使用果蝇，温度，湿度和光/暗周期控制 需要孵化器来容纳动物并进行发育分期实验。