RFA-CK-22-002, Adaptation and assessment of smartphone technology to improve the implementation and evaluation of One Health systems for rabies control and surveillance globally

RFA-CK-22-002，智能手机技术的适应和评估，以改善全球狂犬病控制和监测的 One Health 系统的实施和评估

• 批准号: 10581316
• 负责人: Luke Gamble
• 金额: $ 17.88万
• 依托单位: MISSION RABIES USA, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10581316
• 关键词: RFA; CK; 22; 002; Adaptation

1 Project summary 2 Rabies is one of the most devastating diseases, with near 100% case fatality once clinical signs occur. 3 The vast majority of the tens of thousands of human deaths from rabies every year occur in low- to 4 middle-income countries (LMICs) of Africa and Asia, transmitted through a bite from a rabid dog. 5 Unlike many neglected tropical diseases, rabies is entirely preventable through timely provision of 6 post-exposure prophylaxis (PEP) and elimination through mass vaccination of the dog population has 7 been demonstrated to be both achievable and cost-effective. Nevertheless, children and those at 8 the socioeconomic and geographic margins of society are more likely to die of rabies due to 9 inequities in access to public health services and education, often dying in horrific circumstances 10 without any palliative care. Poor data quality, stemming from limited field-level collection, has been 11 implicated as the singularly most important barrier to rabies control, clouding evidence-based 12 policies and hampering successful control measures. Smartphone and online technologies have 13 revolutionized connectivity between program managers and their remote workforce, enabling field- 14 side digital capture and transmission of programmatic data and spatial communication through 15 interactive maps. The resulting high-resolution data on host population distribution and spatio- 16 temporal rabies case incidence provides new opportunities to optimize control strategies for efficacy 17 and cost-efficiency. This project builds on a long-established program of rabies control interventions 18 across Latin America, Asia and Africa and a versatile platform of technologies developed to support 19 mass dog vaccination and surveillance activities. Further technology development will focus on 20 facilitating widespread democratization of systems, integration with national and international 21 platforms and approaches to support data-driven planning and refinement of rabies control 22 campaigns. Automation of processes for mapping, post-vaccination evaluation and reporting will 23 serve to align strategies and protocols with evidence-based international best-practices for 24 campaign implementation and stimulate engagement with stakeholders at all levels. The impact of 25 novel approaches to the geographic prioritization of vaccination resource on campaign efficiency 26 and rabies transmission will be evaluated. Automated in-app guidance for vaccination team 27 direction, PEP regimen scheduling and the investigation of suspect rabid dogs will be evaluated as 28 compared to non-technology aided approaches. Outcomes of the project will unlock in-country 29 capacity for the implementation of effective One Health rabies control interventions and accelerate 30 progress towards the 2030 global goal for dog-transmitted human rabies elimination.

1个项目摘要 2只狂犬病是最具破坏性的疾病之一，一旦发生临床症状，近100％的病例死亡。 3每年狂犬病的数万人死亡的绝大多数人以低至 非洲和亚洲的4个中等收入国家（LMIC）通过狂犬病狗的咬伤传播。 5与许多被忽视的热带疾病不同，狂犬病完全可以通过及时提供 6个暴露后预防（PEP）和通过大规模接种狗种群的消除 7被证明是可实现且具有成本效益的。然而，孩子和那些 8社会的社会经济和地理边缘更有可能因狂犬病而死于 9在获得公共卫生服务和教育方面的不平等，经常在可怕的情况下死亡 10没有任何姑息治疗。数据质量差，来自有限的现场级收集，已经是 11被暗示是狂犬病控制的最重要的障碍，云 12条政策并阻碍了成功的控制措施。智能手机和在线技术有 13彻底改变了计划经理与其远程劳动力之间的连通性，从而使领域 - 14侧数字捕获和传输程序数据和空间通信 15个互动图。由此产生的有关宿主总体分布和空间的高分辨率数据 16颞狂犬病病例发病率提供了新的机会来优化效力控制策略 17和成本效率。该项目以悠久的狂犬病控制干预措施为基础 18整个拉丁美洲，亚洲和非洲以及为支持的技术平台而开发的技术平台 19大规模狗疫苗接种和监视活动。进一步的技术开发将集中在 20促进系统的广泛民主化，与国家和国际的融合 21种平台和方法支持数据驱动的计划和狂犬病控制的完善 22个运动。用于映射，疫苗接种后评估和报告的流程自动化将 23用于使策略和协议与基于证据的国际最佳实践相结合 24运动实施并刺激各级利益相关者的参与。的影响 25个新的方法，即疫苗接种资源的竞选效率优先级 26和狂犬病的传播将进行评估。疫苗接种团队的自动化内指南 27方向，PEP方案计划和对可疑狂犬犬的调查将被评估为 28与非技术辅助方法相比。该项目的结果将解锁国内 29实施有效的健康狂犬病控制干预措施并加速的能力 30朝着2030年全球狗的狂犬病消除目标的进展。