Colombia-U.S. Fogarty training program on the impact of emerging zoonotic and vector-borne diseases in acute undifferentiated febrile illnesses

哥伦比亚-美国

• 批准号: 10577786
• 负责人: Patricia Veronica Aguilar
• 金额: $ 29.74万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-15 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10577786
• 关键词: 2019-nCoV; Acute; Address; Authorization documentation; Awareness; Bioethics; Bioinformatics; Colombia; Colombian; Country; Dengue; Diagnosis; Diagnostic Procedure; Disease; Doctor of Philosophy; Educational workshop; Electron Microscopy; Enrollment; Ensure; Ethics; Faculty; Fever; Funding; Goals; Grant; Health Personnel; Health Professional; Human; Incidence; Infectious Diseases Research; Institution; Laboratories; Latin America; Leadership; Manuscripts; Mentorship; Methodology; Methods; Molecular; Morbidity - disease rate; Outcome; Postdoctoral Fellow; Preparation; Progress Reports; Public Health; Research; Research Methodology; Research Training; Science; Scientist; Students; Testing; Trainers Training; Training; Training Programs; Training Support; Undifferentiated; Vector-transmitted infectious disease; Visit; Writing; Zoonoses; authority; design; doctoral student; expectation; influenzavirus; interest; low and middle-income countries; member; mortality; novel; novel diagnostics; pathogen; pre-doctoral; programs; recruit; respiratory virus

Abstract Non-malarial acute undifferentiated febrile illnesses (AUFIs) are significant causes of morbidity and mortality in Latin America, and the incidence of dengue-like illness has increased dramatically in recent years. As in most low-and middle-income countries, only a handful of “dengue” cases are confirmed by laboratory testing and therefore many other pathogens remain hidden under the dengue “umbrella”. Lack of proper training among scientists and health care workers was recognized as one of the major obstacles in the diagnosis of AUFIs. To fill this gap, our D43 Global Infectious Disease Research Training Program was launched in 2016, with the goal of forming a strong team of scientists studying non-malarial acute undifferentiated febrile illnesses (AUFIs) in Colombia. Since then, the program has filled a major gap. Over the past five years, we completed advanced training of Colombian Faculty members, predoctoral and postdoctoral students, and conducted short-term training on grant writing and manuscript preparation. The program encompassed short, medium, and long-term research training, and it has exceeded expectations (see Progress Report). The past five years has allowed us to identify additional gaps, challenges, and opportunities. Our new proposed activities will build on our accomplishments and continue to build capacity and train a new group of Colombian Faculty members, PhD students and postdoctoral fellows studying the emerging zoonotic and vector-borne diseases. We will expand the focus of our D43 training program to address respiratory viruses, including SARS-CoV-2 and influenza viruses. We will incorporate training of master’s students enrolled in the Master’s in Basic Biomedical Sciences and implement training on novel molecular and bioinformatic methods, electron microscopy, novel diagnostic methods, grant writing, scientific writing, ethics in scientific research, and biosafety, and for Colombian Faculty, PhD students and postdoctoral fellows, research leadership. Our carefully designed plan includes: 1) In Years 1 and 2, we will support medium-term training of six Colombian Faculty members under a “train the trainer” approach, 2) In Years 1 and 2, we will recruit and support in-country long-term training of master’s students interested in emerging zoonotic and vector-borne diseases working under the mentorship of the Colombian Program Faculty, 3) In Years 3 through 5, we will recruit and support long-term training of PhD, and postdoctoral fellows in the US in advanced research methodologies, scientific writing, biosafety, and bioethics, and, 4) we will conduct short-term in country training in Colombia to ensure appropriate implementation of methodologies, and also conduct specific workshops. We will continue to support training across institutions in the region through in- country visits of US Faculty members and funds will be available for pilot and reinsertion small grants after completion of training. An important planned outcome is the increased awareness of these diseases at the level of human and veterinary health professionals, as well as public health authorities.

抽象的 非疟疾急性未分化的高温疾病（AUFI）是发病率和死亡率的重要原因 近年来，拉丁美洲以及类似登革热疾病的事件急剧增加。和大多数一样 低收入和中等收入国家，仅通过实验室测试和 因此，许多其他病原体仍然隐藏在登革热“伞”下。缺乏适当的培训 科学家和卫生保健工作者被认为是AUFIS诊断的主要障碍之一。到 填补这一空白，我们的D43全球传染病研究培训计划于2016年启动，目标 组成了一个研究非车道急性未分化的高热病（AUFIS）的强大科学家团队 哥伦比亚。从那以后，该计划填补了一个重大差距。在过去的五年中，我们完成了高级 培训哥伦比亚教职员工，占主导地位和博士后学生，并进行了短期 培训赠款写作和手稿准备。该计划涵盖了短期，中和长期的 研究培训及其超出了预期（请参阅进度报告）。过去五年允许我们 确定其他差距，挑战和机遇。我们的新提议的活动将基于我们 成就并继续增强能力，并培训一组新的哥伦比亚教职员工，博士 学生和博士后研究员正在研究新兴的人畜共患病和媒介传播疾病。我们将扩展 我们的D43培训计划的重点是解决呼吸道病毒，包括SARS-COV-2和actractza 病毒。我们将纳入对基础生物医学硕士学位的硕士学生的培训 并实施有关新型分子和生物信息学方法，电子显微镜，新型诊断的培训 方法，赠款写作，科学写作，科学研究中的道德规范和生物安全以及哥伦比亚教职员工， 博士生和博士后研究员，研究领导。我们精心设计的计划包括：1）在1年 2，我们将在“培训培训师”下支持六名哥伦比亚教职员工的中期培训 方法，2）在第1年和第2年，我们将招募和支持国内长期培训硕士学生的长期培训 对新兴的人畜共患病和媒介传播疾病感兴趣 课程教师，3）在第3至5年级，我们将招募和支持博士学位的长期培训和博士后培训 美国的研究员在高级研究方法，科学写作，生物安全和生物伦理学中，以及4）我们将 在哥伦比亚进行短期培训，以确保适当的方法实施 我们将继续支持该地区跨该机构的培训 国家访问美国教职员工和资金将用于飞行员和再插入小额赠款 完成培训。一个重要的计划结果是对这些疾病的意识提高了 人类和兽医专业人士以及公共卫生当局