Colombia-U.S. Fogarty training program on the impact of emerging zoonotic and vector-borne diseases in acute undifferentiated febrile illnesses

哥伦比亚-美国

基本信息

批准号：
10240140
负责人：
Patricia Veronica Aguilar
金额：
$ 30.1万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-15 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10240140
关键词：
2019-nCoV Acute Address Awareness Bioethics Bioinformatics Colombia Colombian Country Dengue Diagnosis Diagnostic Procedure Disease Doctor of Philosophy Educational workshop Electron Microscopy Enrollment Ensure Ethics Faculty Fever Funding Goals Grant Health Personnel Health Professional Human Incidence Infectious Diseases Research Institution Laboratories Latin America Leadership Manuscripts Mentorship Methodology Methods Molecular Morbidity - disease rate Outcome Postdoctoral Fellow Preparation Progress Reports Public Health Research Research Methodology Research Training Science Scientist Students Testing Trainers Training Training Training Programs Training Support Undifferentiated Vector-transmitted infectious disease Visit Writing Zoonoses authority design doctoral student expectation influenzavirus interest low and middle-income countries member mortality novel novel diagnostics pathogen pre-doctoral programs recruit respiratory virus

项目摘要

Abstract Non-malarial acute undifferentiated febrile illnesses (AUFIs) are significant causes of morbidity and mortality in Latin America, and the incidence of dengue-like illness has increased dramatically in recent years. As in most low-and middle-income countries, only a handful of “dengue” cases are confirmed by laboratory testing and therefore many other pathogens remain hidden under the dengue “umbrella”. Lack of proper training among scientists and health care workers was recognized as one of the major obstacles in the diagnosis of AUFIs. To fill this gap, our D43 Global Infectious Disease Research Training Program was launched in 2016, with the goal of forming a strong team of scientists studying non-malarial acute undifferentiated febrile illnesses (AUFIs) in Colombia. Since then, the program has filled a major gap. Over the past five years, we completed advanced training of Colombian Faculty members, predoctoral and postdoctoral students, and conducted short-term training on grant writing and manuscript preparation. The program encompassed short, medium, and long-term research training, and it has exceeded expectations (see Progress Report). The past five years has allowed us to identify additional gaps, challenges, and opportunities. Our new proposed activities will build on our accomplishments and continue to build capacity and train a new group of Colombian Faculty members, PhD students and postdoctoral fellows studying the emerging zoonotic and vector-borne diseases. We will expand the focus of our D43 training program to address respiratory viruses, including SARS-CoV-2 and influenza viruses. We will incorporate training of master’s students enrolled in the Master’s in Basic Biomedical Sciences and implement training on novel molecular and bioinformatic methods, electron microscopy, novel diagnostic methods, grant writing, scientific writing, ethics in scientific research, and biosafety, and for Colombian Faculty, PhD students and postdoctoral fellows, research leadership. Our carefully designed plan includes: 1) In Years 1 and 2, we will support medium-term training of six Colombian Faculty members under a “train the trainer” approach, 2) In Years 1 and 2, we will recruit and support in-country long-term training of master’s students interested in emerging zoonotic and vector-borne diseases working under the mentorship of the Colombian Program Faculty, 3) In Years 3 through 5, we will recruit and support long-term training of PhD, and postdoctoral fellows in the US in advanced research methodologies, scientific writing, biosafety, and bioethics, and, 4) we will conduct short-term in country training in Colombia to ensure appropriate implementation of methodologies, and also conduct specific workshops. We will continue to support training across institutions in the region through in- country visits of US Faculty members and funds will be available for pilot and reinsertion small grants after completion of training. An important planned outcome is the increased awareness of these diseases at the level of human and veterinary health professionals, as well as public health authorities.

抽象的非疟疾急性未分化发热性疾病 (AUFI) 是儿童发病和死亡的重要原因与大多数地区一样，拉丁美洲和登革热类疾病的发病率近年来急剧增加。在低收入和中等收入国家，只有少数“登革热”病例通过实验室检测和确诊因此，许多其他病原体仍然隐藏在登革热“保护伞”之下。缺乏适当的培训。科学家和卫生保健工作者被认为是诊断AUFI的主要障碍之一。为了填补这一空白，我们于 2016 年启动了 D43 全球传染病研究培训计划，其目标组建一支强大的科学家团队，研究非疟疾急性未分化发热性疾病（AUFI）哥伦比亚：从那时起，该计划在过去五年中填补了一项重大空白。对哥伦比亚教员、博士前和博士后学生进行培训，并进行了短期培训该计划包括短期、中期和长期培训。研究培训，并且超出了我们的预期（参见进度报告）。以确定其他差距、挑战和机遇。我们新提议的活动将建立在我们的基础上。成就并继续建设能力并培训一批新的哥伦比亚教职人员、博士我们将扩大研究新出现的人畜共患病和媒介传播疾病的学生和博士后。我们 D43 培训计划的重点是应对呼吸道病毒，包括 SARS-CoV-2 和流感我们将纳入对基础生物医学硕士研究生的培训。并实施新型分子和生物信息方法、电子显微镜、新型诊断方法的培训方法、拨款写作、科学写作、科学研究伦理和生物安全，以及哥伦比亚教师，博士生和博士后研究人员，我们精心设计的计划包括： 1) 在第一年。 2，我们将支持六名哥伦比亚教员在“培训师培训”下的中期培训 2）第一年和第二年，我们将招募和支持硕士生在国内长期培养对在哥伦比亚的指导下工作的新出现的人畜共患病和媒介传播疾病感兴趣项目教师，3）在第3年至第5年，我们将招募和支持博士和博士后的长期培训美国高级研究方法、科学写作、生物安全和生物伦理学领域的研究员，4) 我们将在哥伦比亚进行短期国家培训，以确保方法的适当实施，以及我们还将继续通过内部培训支持该地区各机构的培训。美国教职人员的国家访问和资金将可用于试点和重新插入小额赠款培训的一个重要计划成果是提高了对这些疾病的认识。人类和兽医卫生专业人员以及公共卫生当局。