Functional Immunomics Core

功能免疫组学核心

基本信息

批准号：
10577767
负责人：
Bing Li
金额：
$ 46.69万
依托单位：
UNIVERSITY OF LOUISVILLE
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10577767
关键词：
Applications Grants Area Biological Specimen Banks Blood Cancer Center Cancer Patient Cell Separation Cells Centers of Research Excellence Clinic Clinical Contract Services Core Facility Cytometry DNA Data Databases Decentralization Dedications Development Education Ensure Extramural Activities Fee-for-Service Plans Flow Cytometry Freezing Funding Future Genomics Goals Human Human Resources Immune Immune system Immunofluorescence Immunologic Immunologic Monitoring Immunologics Immunooncology Immunotherapy Infrastructure Institution Investments Kentucky Location Malignant Neoplasms Molecular Mus Paraffin Embedding Patients Phase Phenotype Process Proteins Protocols documentation Publications Qualifying RNA Research Research Personnel Research Support Resources Running Sampling Services Site Slide Specimen Stains Technology Tissues Training Training and Education Translations Tumor-Associated Process Universities University resources Writing cancer immunotherapy clinical application design equipment acquisition innovation instrument instrumentation interest member new therapeutic target novel operation prospective success tissue processing tissue/cell preparation transcriptomics treatment strategy tumor tumor immunology

项目摘要

SUMMARY (Functional Immunomics Core) The primary goal of the Functional Immunomics Core (FIC) is to serve as the central infrastructure entity that supports all the investigators in the Center for Cancer Immunology and Immunotherapy (CCII) COBRE. FIC will utilize new equipment purchased with institutional funds and leverage existing facilities at the University of Louisville to provide molecular/cellular immune profiling for mouse and human projects in the CCII. Specific Aim 1 is to build a functional immunomics facility at the University of Louisville. With the support of CCII, we will establish a streamlined state-of-the-art immunomics facility in a central location by incorporating the existing resources of the University of Louisville. This unique resource will act as a vital integrative component of the CCII through providing centralized services not only for its members but also for the Institution as a whole. Specific Aim 2 is to utilize the comprehensive and integrative FIC platform to ensure the success of CCII-supported projects. The major goal of the FIC will be to support the development, progress and success of proposed CCII projects in all phases of their research. Particularly, the FIC will provide human sample analytics expertise and technical services to support the specific aims of the CCII projects. Specific Aim 3 is to facilitate translational cancer immunology/immunotherapy research and develop a self-sustaining entity of the CCII through University/region-wide services. In summary, by integrating with the existing resources at the UofL, the newly-established FIC will provide a comprehensive immunomics service center for the success of the proposed CCII projects and the translation of novel experimental discoveries to clinical applications.

摘要（功能免疫组学核心）功能免疫组学核心 (FIC) 的主要目标是作为中央基础设施实体，支持癌症免疫学和免疫治疗中心 (CCII) COBRE 的所有研究人员。 FIC 将利用机构资金购买的新设备并利用大学的现有设施路易斯维尔将为 CCII 中的小鼠和人类项目提供分子/细胞免疫分析。具体的目标 1 是在路易斯维尔大学建立功能性免疫组学设施。在CCII的支持下，我们将在中心位置建立一个精简的、最先进的免疫组学设施，将路易斯维尔大学的现有资源。这种独特的资源将成为重要的综合组成部分 CCII 不仅为其成员而且还为该机构提供集中服务所有的。具体目标2是利用全面、综合的FIC平台确保项目的成功 CCII 支持的项目。 FIC 的主要目标是支持发展、进步和成功拟议的 CCII 项目在其研究的各个阶段。特别是，FIC将提供人体样本分析专业知识和技术服务，以支持 CCII 项目的具体目标。具体目标 3 是促进转化癌症免疫学/免疫治疗研究并开发一个自我维持的实体 CCII 通过大学/地区范围内的服务。综上所述，通过整合现有资源 UofL，新成立的FIC将为以下项目的成功提供全面的免疫组学服务中心：拟议的 CCII 项目以及将新的实验发现转化为临床应用。