2/2 Southeast Partnership for Improving Research & Training in Cancer Health Disparities

2/2 东南部改善研究伙伴关系

基本信息

批准号：
10005277
负责人：
Paula Elizabeth Gregory
金额：
$ 24.78万
依托单位：
LSU HEALTH SCIENCES CENTER
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-21 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10005277
关键词：
African African American Applications Grants Area Awareness Basic Science Behavior Biological Biological Specimen Banks Cancer Biology Cancer Center Cancer Center Support Grant Caring Catchment Area Censuses Chemicals Clinical Clinical Research Collaborations Communities Comprehensive Cancer Center Correlation Studies Data Databases Development Diagnosis Education Education and Outreach Educational Curriculum Ethnic Origin European Evolution Expression Profiling Florida Foundations Funding Galanin Gene Expression Genetic Genomics Geographic Locations Goals Health Health Professional Health Sciences Hispanics Home environment Hurricane Immunology Inflammation Infrastructure Institution Joints Language Latina Lead Location Louisiana Malignant Neoplasms Medical Students Minority Mission Mississippi Molecular Molecular Biology NCI-Designated Cancer Center Native Americans Outcome Patients Philosophy Pilot Projects Population Population Heterogeneity Population Research Prevention Production RNA methylation Race Research Research Institute Research Personnel Research Project Grants Research Training Resource Sharing Resources Rural Science Specimen Students Technology Tissue Microarray Translational Research Tumor Immunity Underrepresented Populations Underrepresented Students Underserved Population Universities ancestry analysis anticancer research base biobank breast cancer genomics cancer care cancer education cancer epidemiology cancer health disparity cancer immunotherapy cancer prevention cancer risk cancer stem cell career development education research epigenomics ethnic diversity ethnic minority population experience health disparity improved inter-institutional literacy malignant breast neoplasm member minority communities minority-serving hospitals molecular subtypes new therapeutic target next generation novel novel marker outcome forecast patient population precision medicine precision oncology programs racial and ethnic racial diversity summer research tool transcriptome sequencing treatment response undergraduate student

项目摘要

The Southeast Partnership for Improving Research & Training in Cancer Health Disparities (SPIRIT- CHD) unites the Louisiana State University Health Sciences Center (LSUHSC), an institution serving underserved populations and underrepresented students (ISUPS), and the NCI-designated Moffitt Cancer Center (MCC) to advance translational research on the biological mechanisms of cancer health disparities focusing on biospecimen-based research and precision medicine. It also seeks to establish a joint cancer research education program focused on biobanking and precision medicine education. LSUHSC serves a region characterized by an underserved African-American population, and rampant cancer health disparities in the wake of Hurricane Katrina. This region has several growing racial/ethnic minority populations. After Hurricane Katrina, the Hispanic population in Louisiana doubled and is now the fastest growing ethnic minority. MCC is located in Tampa, Florida and serves an increasingly wide catchment area characterized by a population diverse in regard to age, race/ethnicity, language and literacy, and is home to an increasing Latino population. Precision medicine research requires: a well-managed, ethnically and racially diverse biospecimen repository; state of the art technology in genomics, epigenomics and ancestry analysis; availability of language, cultural and literacy specific educational tools and resources; and a research education infrastructure that promotes a pipeline of trainees in cancer disparities research. MCC is a national leader and pioneer in these areas, has highly integrated research programs, and seeks to expand the diversity of their biospecimen research endeavors. This partnership is based on two Specific Aims. Specific Aim 1: Plan and execute two collaborative pilot research projects. The first pilot research project focuses on breast cancer genomics, studying biospecimens from Hispanic/Latina patients of mixed genetic ancestry (African, Native American, European) by RNA sequencing (RNASeq) and methylation analysis, to study correlations between molecular subtypes, gene expression profiles, clinical outcomes and ancestry. This project will support the career development of racial/ethnic minority early-stage investigators at LSUHSC and MCC. Specific Aim 2: Plan a collaborative three-pronged cancer research education program that includes: 1) a hands-on summer research experience for undergraduate and medical students; 2) delivery of a curriculum to those students focusing on biobanking, precision medicine and cancer health disparities; and 3) expansion of outreach education to our respective communities about biobanking, precision medicine and cancer health disparities. The combination of these collaborative partnership activities is expected to offer mutual benefit to each institution to impact cancer health disparities, inspire the next generation of researchers, and rapidly lead to the submission of competitive grant applications. Importantly, our main collaborative goal is to bring the benefits of cancer research advancements to underserved communities.

改善癌症健康差异研究和培训的东南合作伙伴关系 (SPIRIT- CHD）联合了路易斯安那州立大学健康科学中心 (LSUHSC)，这是一个服务于服务不足的人群和代表性不足的学生 (ISUPS)，以及 NCI 指定的莫菲特癌症中心（MCC）将推进癌症健康差异生物学机制的转化研究专注于基于生物样本的研究和精准医学。它还试图建立一种联合癌症研究教育计划侧重于生物样本库和精准医学教育。 LSUHSC 服务于该地区的特点是非裔美国人人口服务水平低下，以及癌症健康差距严重卡特里娜飓风过后。该地区的少数种族/族裔人口不断增长。后卡特里娜飓风过后，路易斯安那州的西班牙裔人口增加了一倍，现在是增长最快的少数民族。 MCC 位于佛罗里达州坦帕，服务于日益广阔的集水区，其特点是人口在年龄、种族/族裔、语言和文化水平方面存在差异，并且是越来越多拉丁裔的家园人口。精准医学研究需要：管理良好、民族和种族多样化的生物样本存储库；最先进的基因组学、表观基因组学和祖先分析技术；语言的可用性，特定于文化和扫盲的教育工具和资源；以及研究教育基础设施促进癌症差异研究的培训生管道。中冶集团在这些领域处于国内领先者和先行者地位领域，拥有高度综合的研究项目，并寻求扩大其生物样本的多样性研究努力。这种伙伴关系基于两个具体目标。具体目标 1：计划并执行两个合作试点研究项目。第一个试点研究项目侧重于乳腺癌基因组学，研究来自混合遗传血统的西班牙裔/拉丁裔患者（非洲人、美洲原住民、欧洲）通过RNA测序（RNASeq）和甲基化分析，研究分子之间的相关性亚型、基因表达谱、临床结果和血统。该项目将支持职业生涯 LSUHSC 和 MCC 少数族裔早期研究人员的发展。具体目标 2：计划 a 三管齐下的合作癌症研究教育计划，包括：1）暑期实践研究本科生和医学生的经验； 2）向学生提供课程，重点关注生物样本库、精准医学和癌症健康差异； 3）扩大外展教育各个社区关于生物样本库、精准医学和癌症健康差异的问题。组合这些合作伙伴关系活动预计将为每个机构带来互惠互利，以影响癌症健康差异，激励下一代研究人员，并迅速导致提交竞争性拨款申请。重要的是，我们的主要合作目标是带来癌症的益处服务欠缺社区的研究进展。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Asthma status moderates the relationship between neighbourhood disadvantage and obesity in African American adolescent females.

哮喘状况调节了非裔美国青春期女性的邻里劣势与肥胖之间的关系。

DOI：
10.1002/osp4.370
发表时间：
2019
期刊：
Obesity science & practice
影响因子：
2.2
作者：
Cahill,LauraM;Fisher,KivaA;Robinson,WilliamT;Beiter,KaylinJ;Zabaleta,Jovanny;Tseng,TungS;Kepper,MauraM;Skizim,MegK;Griffiths,LaurenA;Uddo,RobertB;Pelligrino,NicoleE;Maronge,JacobM;Happel,Kyle;Scribner,Richard;Sothern
通讯作者：
Sothern

Ancestry as a potential modifier of gene expression in breast tumors from Colombian women.

DOI：
10.1371/journal.pone.0183179
发表时间：
2017
期刊：
PloS one
影响因子：
3.7
作者：
Serrano-Gómez SJ;Sanabria-Salas MC;Garay J;Baddoo MC;Hernández-Suarez G;Mejía JC;García O;Miele L;Fejerman L;Zabaleta J
通讯作者：
Zabaleta J

Advanced bioinformatic analysis and pathway prediction of NSCLC cells upon cisplatin resistance.

DOI：
10.1038/s41598-021-85930-y
发表时间：
2021-03-22
期刊：
Scientific reports
影响因子：
4.6
作者：
Hossian AKMN;Zahra FT;Poudel S;Abshire CF;Polk P;Garai J;Zabaleta J;Mikelis CM;Mattheolabakis G
通讯作者：
Mattheolabakis G

New Insights into Avian Infectious Bronchitis Virus in Colombia from Whole-Genome Analysis.

DOI：
10.3390/v14112562
发表时间：
2022-11-19
期刊：
Viruses
影响因子：
0
作者：
Ramirez-Nieto G;Mir D;Almansa-Villa D;Cordoba-Argotti G;Beltran-Leon M;Rodriguez-Osorio N;Garai J;Zabaleta J;Gomez AP
通讯作者：
Gomez AP

Comparative analysis of miRNA profile in human dendritic cells infected with respiratory syncytial virus and human metapneumovirus.