2/2 Southeast Partnership for Improving Research & Training in Cancer Health Disparities

2/2 东南部改善研究伙伴关系

• 批准号: 9767095
• 负责人: Paula Elizabeth Gregory
• 金额: $ 24.04万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-21 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9767095
• 关键词: African; African American; Applications Grants; Area; Awareness; Basic Science; Behavior; Biological; Cancer Biology; Cancer Center; Cancer Center Support Grant; Caring; Catchment Area; Censuses; Chemicals; Clinical; Clinical Research; Collaborations; Communities; Comprehensive Cancer Center; Correlation Studies; Data; Databases; Development; Diagnosis; Education; Education and Outreach; Educational Curriculum; Ethnic Origin; European; Evolution; Expression Profiling; Florida; Foundations; Funding; Galanin; Gene Expression; Genetic; Genomics; Geographic Locations; Goals; Health; Health Professional; Health Sciences; Hispanics; Home environment; Hurricane; Immunity; Immunology; Inflammation; Infrastructure; Institution; Joints; Language; Latina; Lead; Location; Louisiana; Malignant Neoplasms; Medical Students; Minority; Mission; Mississippi; Molecular; Molecular Biology; NCI-Designated Cancer Center; Native Americans; Outcome; Patients; Philosophy; Pilot Projects; Population; Population Heterogeneity; Population Research; Prevention; Production; RNA methylation; Race; Research; Research Institute; Research Personnel; Research Project Grants; Research Training; Resource Sharing; Resources; Rural; Science; Specimen; Students; Technology; Tissue Microarray; Translational Research; Underrepresented Populations; Underrepresented Students; Underserved Population; Universities; anticancer research; base; biobank; breast cancer genomics; cancer care; cancer education; cancer epidemiology; cancer health disparity; cancer immunotherapy; cancer prevention; cancer risk; cancer stem cell; career development; education research; epigenomics; ethnic diversity; ethnic minority population; experience; health disparity; improved; inter-institutional; literacy; malignant breast neoplasm; member; minority communities; minority-serving hospitals; molecular subtypes; new therapeutic target; next generation; novel; novel marker; outcome forecast; patient population; precision medicine; precision oncology; programs; racial and ethnic; racial diversity; repository; summer research; tool; transcriptome sequencing; treatment response; undergraduate student

The Southeast Partnership for Improving Research & Training in Cancer Health Disparities (SPIRIT- CHD) unites the Louisiana State University Health Sciences Center (LSUHSC), an institution serving underserved populations and underrepresented students (ISUPS), and the NCI-designated Moffitt Cancer Center (MCC) to advance translational research on the biological mechanisms of cancer health disparities focusing on biospecimen-based research and precision medicine. It also seeks to establish a joint cancer research education program focused on biobanking and precision medicine education. LSUHSC serves a region characterized by an underserved African-American population, and rampant cancer health disparities in the wake of Hurricane Katrina. This region has several growing racial/ethnic minority populations. After Hurricane Katrina, the Hispanic population in Louisiana doubled and is now the fastest growing ethnic minority. MCC is located in Tampa, Florida and serves an increasingly wide catchment area characterized by a population diverse in regard to age, race/ethnicity, language and literacy, and is home to an increasing Latino population. Precision medicine research requires: a well-managed, ethnically and racially diverse biospecimen repository; state of the art technology in genomics, epigenomics and ancestry analysis; availability of language, cultural and literacy specific educational tools and resources; and a research education infrastructure that promotes a pipeline of trainees in cancer disparities research. MCC is a national leader and pioneer in these areas, has highly integrated research programs, and seeks to expand the diversity of their biospecimen research endeavors. This partnership is based on two Specific Aims. Specific Aim 1: Plan and execute two collaborative pilot research projects. The first pilot research project focuses on breast cancer genomics, studying biospecimens from Hispanic/Latina patients of mixed genetic ancestry (African, Native American, European) by RNA sequencing (RNASeq) and methylation analysis, to study correlations between molecular subtypes, gene expression profiles, clinical outcomes and ancestry. This project will support the career development of racial/ethnic minority early-stage investigators at LSUHSC and MCC. Specific Aim 2: Plan a collaborative three-pronged cancer research education program that includes: 1) a hands-on summer research experience for undergraduate and medical students; 2) delivery of a curriculum to those students focusing on biobanking, precision medicine and cancer health disparities; and 3) expansion of outreach education to our respective communities about biobanking, precision medicine and cancer health disparities. The combination of these collaborative partnership activities is expected to offer mutual benefit to each institution to impact cancer health disparities, inspire the next generation of researchers, and rapidly lead to the submission of competitive grant applications. Importantly, our main collaborative goal is to bring the benefits of cancer research advancements to underserved communities.

改善癌症健康差异研究与培训的东南伙伴关系（Spirit- CHD）团结路易斯安那州立大学健康科学中心（LSUHSC），这是一家服务的机构 服务不足的人群和代表性不足的学生（ISUP）和NCI指定的莫菲特癌 中心（MCC）推进有关癌症健康差异生物学机制的转化研究 专注于基于生物的研究和精确医学。它还试图建立联合癌症 研究教育计划的重点是生物群和精密医学教育。 LSUHSC服务a 地区的特征是服务不足的非裔美国人人口，并且癌症健康差异猖ramp 卡特里娜飓风的唤醒。该地区有几个种族/族裔少数民族人口。后 路易斯安那州西班牙裔人口卡特里娜飓风翻了一番，现在是增长最快的少数民族。 MCC位于佛罗里达州坦帕市，提供越来越宽的集水区，其特征是 人口在年龄，种族/种族，语言和识字方面都有多种多样，并且是越来越多的拉丁裔 人口。 Precision medicine research requires: a well-managed, ethnically and racially diverse biospecimen 存储库；基因组学，表观基因组学和祖先分析的最先进技术；语言的可用性， 文化和扫盲特定的教育工具和资源；以及研究教育基础设施 促进了癌症差异研究的学员。 MCC是这些国家领导者和先驱 领域，拥有高度综合的研究计划，并试图扩大其生物测试的多样性 研究努力。该伙伴关系基于两个具体目标。特定目标1：计划和执行两个 协作试点研究项目。第一个试点研究项目的重点是乳腺癌基因组学， 研究混合遗传血统的西班牙裔/拉丁裔患者（非洲人，美国原住民，， 欧洲）通过RNA测序（RNASEQ）和甲基化分析，研究分子之间的相关性 亚型，基因表达谱，临床结果和祖先。这个项目将支持职业 LSUHSC和MCC的种族/族裔少数民族早期研究人员的发展。特定目标2：计划A 协作三管齐下的癌症研究教育计划，其中包括：1）动手夏季研究 本科生和医学生的经验； 2）向专注于关注的学生提供课程 生物群，精密医学和癌症健康差异； 3）扩大外展教育向我们的 有关生物群，精密医学和癌症健康差异的各自社区。组合 预计这些协作伙伴关系活动将为每个机构提供互惠互利，以影响 癌症健康差异，激发下一代研究人员，并迅速导致提交 竞争性赠款申请。重要的是，我们的主要协作目标是带来癌症的好处 研究进步对欠服务的社区。