FUNCTIONAL CORRELATES OF GPI DEEP BRAIN STIMULATION IN PRIMARY DYSTONIA

GPI 深部脑刺激治疗原发性肌张力障碍的功能相关性

• 批准号: 7719284
• 负责人: Maren Carbon-Correll
• 金额: $ 1.38万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-22 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719284
• 关键词: Brain region; Cerebral cortex; Computer Retrieval of Information on Scientific Projects Database; Deep Brain Stimulation; Dystonia; Funding; Grant; Institution; Intervention; Medical; Movement; Operative Surgical Procedures; Patients; Primary Dystonias; Regulation; Research; Research Personnel; Resources; Source; Symptoms; Testing; United States National Institutes of Health; Work

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. For dystonia patients who do not respond to medical therapy, surgical treatment with deep brain stimulation (GPi DBS) can reduce symptoms. However, the precise mechanism by which this intervention works is unknown. We hypothesize that dystonia is caused by a disturbance of the functional connections between the frontal cerebral cortex and subcortical brain regions involved in movement regulation. In the proposed studies, we will test the hypothesis whether this functional disturbance can be corrected by effective GPi DBS.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 对于对药物治疗没有反应的肌张力障碍患者，采用深部脑刺激（GPi DBS）的手术治疗可以减轻症状。然而，这种干预作用的确切机制尚不清楚。我们假设肌张力障碍是由参与运动调节的额叶大脑皮层和皮层下大脑区域之间的功能连接紊乱引起的。在拟议的研究中，我们将检验这种功能障碍是否可以通过有效的 GPi DBS 来纠正的假设。