IN VIVO MAPPING OF INCREMENTAL CORTICAL ATROPHY FROM HEALTH TO

体内皮质萎缩从健康状态到

• 批准号: 7955772
• 负责人: ANNAPAOLA PRESTIA
• 金额: $ 0.34万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955772
• 关键词: Acceleration; Alzheimer' s Disease; Atrophic; Brain region; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Deceleration; Dimensions; Disease; Disease Progression; Dorsal; Four-dimensional; Funding; Grant; Health; Institution; Late Onset Alzheimer Disease; Magnetic Resonance Imaging; Maps; Medial; Methods; Modeling; Outcome; Parietal; Patients; Pattern; Persons; Pharmaceutical Preparations; Research; Research Personnel; Resolution; Resources; Severity of illness; Source; Therapeutic Intervention; United States National Institutes of Health; Visual Cortex; cerebral atrophy; computational anatomy; gray matter; in vivo; mental state

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. "In vivo mapping of incremental cortical atrophy from health to overt Alzheimer's Disease" Background: Progressive atrophy in critical brain regions is one of the hallmarks of Alzheimer's disease (AD) and a candidate surrogate outcome in clinical trials of disease-modifying drugs. Aim of this study is to map the topography of acceleration-deceleration of cortical atrophy from health through incipient and mild to moderate AD. Methods: 20 older healthy persons (OH, Mini Mental State Exam 29.1¿1.0), 11 patients with incipient (iAD, 26.5¿2.0), 15 with mild (miAD, 23.5¿2.2), and 15 with moderate sporadic late-onset AD (moAD, 16.5¿2.0) had high resolution 3D magnetic resonance (MR) imaging. Cortical pattern matching analysis was performed, allowing to map cortical atrophic changes with a precision of few mm. Maps of percent difference and statistical significance were computed between the following groups: iAD vs. OH, miAD vs. iAD, and moAD vs. miAD. Results: Compared to OH, iAD featured cortical gray matter loss of 20-30% in the medial temporal, posterior cingulate, orbitofrontal cortices, and less widespread loss of 15-20% in the temporoparietal region. Compared to iAD, miAD featured widespread temporal, temporoparietal, dorsal parietal, and dorsal frontal gray matter loss of 30% and above, with less marked loss in the medial temporal (10-20%) and posterior cingulate regions (10-15%). Compared to miAD, moAD featured gray matter loss of 25-30% in the primary sensorimotor and visual cortices, loss in the temporal, parietal, and frontal regions being markedly lower (below 10%). Conclusion: These findings are preliminary to draw a 4-dimensional map (3 dimensions in space plus disease severity) of cortical involvement that might be the reference for therapeutic interventions aimed to modify disease progression.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以出现在其他 CRISP 条目中 列出的机构是。 对于中心来说，它不一定是研究者的机构。 “从健康到明显的阿尔茨海默病的增量皮质萎缩的体内图谱” 背景：关键大脑区域的进行性萎缩是阿尔茨海默病 (AD) 的标志之一，也是疾病缓解药物临床试验的候选替代结果。本研究的目的是绘制皮质萎缩加速-减速的拓扑图。通过早期和轻度至中度 AD 保持健康。 方法：20 名老年健康人（OH，简易精神状态检查 29.1¿1.0）、11 名初发 AD 患者（iAD，26.5¿2.0）、15 名轻度患者（miAD，23.5¿2.2）和 15 名中度散发性迟发性 AD 患者（moAD，16.5¿2.0）具有高分辨率 3D 磁共振 (MR) 皮质成像。进行模式匹配分析，以几毫米的精度绘制皮质萎缩变化图，计算以下组之间的百分比差异和统计显着性：iAD 与 OH、miAD 与 iAD 以及 moAD 与 miAD。 结果：与 OH 相比，iAD 的特点是内侧颞叶、后扣带回、眶额皮质灰质损失 20-30%，而颞顶区域的灰质损失范围较小，为 15-20% 与 iAD 相比，miAD 的特点是广泛的颞叶灰质损失。 、颞顶叶、背侧顶叶和背侧额叶灰质损失达 30% 及以上，内侧颞叶损失较不明显与 miAD 相比，moAD 的灰质损失为 25-30%，颞叶、顶叶和额叶区域的灰质损失为 25-30%。明显降低（低于 10%）。 结论：这些发现初步绘制了皮质受累的 4 维图（空间中的 3 个维度加上疾病严重程度），这可能为旨在改变疾病进展的治疗干预措施提供参考。