Modulation of the Vestibular System Using Prosthetic Direct Current Stimulation

使用假体直流电刺激调节前庭系统

• 批准号: 10577751
• 负责人: Charles C Della Santina
• 金额: $ 57.29万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10577751
• 关键词: 3-Dimensional; Acute; Advanced Development; Animal Model; Artificial Implants; Basic Science; Bilateral; Biological; Biological Assay; Catheters; Characteristics; Charge; Chinchilla (genus); Chronic; Clinical; Cochlear Implants; Corrosion; Darkness; Data; Development; Device or Instrument Development; Devices; Disabled Persons; Drops; Ear; Electrodes; Engineering; Esthesia; Evaluation; Foundations; Frequencies; Functional disorder; Future; Gel; Goals; Hair Cells; Head; Histologic; Human; Hydrolysis; Implant; Injections; Institution; Labyrinth; Lead; Metals; Microfluidics; Monkeys; Motion; Nervous System; Neurons; Operative Surgical Procedures; Outcome; Pacemakers; Performance; Phase; Physiologic pulse; Physiological; Preparation; Primates; Prosthesis; Protocols documentation; Reaction; Research; Rotation; Safety; Saline; Scheme; Spinal Cord; Stimulus; System; Technology; Testing; Therapeutic; Tissues; Translating; Translational Research; Translations; Tube; United States Food and Drug Administration; Vestibular Hair Cells; Vestibular Nerve; Vestibular loss; Work; behavioral study; deep brain stimulator; design; equilibration disorder; first-in-human; implantation; improved; instrument; neural; neural implant; neural prosthesis; neuroprosthesis; neuroregulation; nonhuman primate; novel; pre-clinical; prototype; response; retina implantation; vestibular prosthesis; vestibulo-ocular reflex; wireless

Project Summary The central goal of this project is to advance the therapeutic application and the development of an exciting novel neuroprosthetic technology, Safe Direct Current Stimulation (SDCS). Direct current (DC) compared to biphasic charge balanced pulses normally used by neural prostheses to interface to the nervous system, can more naturally control neural activity. Unlike biphasic current pulses used to excite neurons, DC can excite, inhibit, and modulate sensitivity of neurons. However using DC for implantable prosthetic applications has not been possible due to the DC’s inherent violation of the charge injection safety constraints at the metal electrode interfaces. Safe DC overcomes these constraints and opens a new avenue for research into exciting possibilities of using DC to interface to the nervous system. We will optimize the use of SDCS to improve the performance of the vestibular prosthetic for balance disorders. This type of neural implant is designed to deliver the sensation of head motion directly to the vestibular nerve for those suffering from bilateral vestibular dysfunction. We obtained preliminary data in a chinchilla animal model showing that using DC in contrast to the more conventional pulsatile stimulation can dramatically increase the range of head velocities that can be encoded by the device. Here we propose to consider biological safety of long-duration SDCS prosthetic stimulation, and advance the technology SDCS toward primate implantation. Aim 1) Conduct acute behavioral studies in nonhuman primates. Aim 2) Determine whether prolonged DC delivery from the SDCS causes physiologic or histologic signs of damage in chinchillas. Aim 3) Develop a three channel SDCS, lead, and DCtubes designed for future primate chronic vestibular implant studies.

项目摘要 该项目的核心目标是推进治疗应用和开发 令人兴奋的新型神经假体技术，安全直接电流刺激（SDC）。直流电（DC） 与通常由神经假体使用的双相电荷平衡脉冲相比 系统，可以更自然地控制神经元活动。与用于激发神经元的双相电流脉冲不同，DC可以 激发，抑制和调节神经元灵敏度。但是，使用DC进行可植入的假肢应用 由于DC的继承违反了金属的收费安全限制，因此无法实现 电极接口。安全DC克服了这些限制，并为研究开辟了新的途径 使用直流与神经系统接口的令人兴奋的可能性。 我们将优化使用SDC来提高前庭假肢的性能以达到平衡 疾病。这种类型的神经植入物旨在将头部运动的感觉直接传递到前庭 对于患有双侧前庭功能障碍的人的神经。我们在龙猫动物中获得了初步数据 模型表明，与更传统的脉动刺激相反，使用直流可以急剧增加 设备可以编码的头部速度的范围。在这里，我们建议考虑生物安全 长期SDCS假肢刺激，并将技术SDC推向灵长类动物植入。 目标1）在非人类隐私中进行急性行为研究。 目标2）确定从SDC延长直流传递是否引起生理或组织学迹象 龙猫的伤害。 目标3）开发为未来灵长类动物慢性前庭设计的三个通道SDC，铅和dctubes 植入研究。