11/15/18. Bowers. Resub R01. Linking pre- and post-natal psychosocial determinants, DNA methylation, and early developmental health disparities

2018 年 11 月 15 日。

• 批准号: 10573269
• 负责人: Katherine A Bowers
• 金额: $ 60.23万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-26 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10573269
• 关键词: Academic achievement; Adolescence; Adverse event; Affect; Arousal; Attention; Behavioral; Biological; Birth; Brain; Child; Child Development; Child Rearing; Childhood; Cognitive; DNA Methylation; Data; Data Collection; Development; Developmental Delay Disorders; Disparity; Early Intervention; Early identification; Effectiveness; Emotional; Enrollment; Environment; Epigenetic Process; Evidence based intervention; Exposure to; Family; Financial Hardship; Genes; Glucocorticoid Receptor; Goals; Home visitation; Hydroxysteroid Dehydrogenases; Impaired cognition; Impairment; Infant; Infant Development; Intervention; Life; Life Cycle Stages; Link; Measures; Mediating; Mothers; NR3C1 gene; Outcome; Pathway interactions; Perinatal; Phenotype; Population; Population Heterogeneity; Populations at Risk; Positioning Attribute; Poverty; Predisposition; Pregnancy; Public Health; Reduce health disparities; Research; Risk; Risk Factors; Role; Services; Site; Social support; Stress; System; Time; Translating; United States; Urban Population; Visit; Woman; Work; age related; biological adaptation to stress; dosage; early childhood; epigenetic marker; experience; health care quality; health disparity; improved; in utero; infancy; intervention program; lower income families; maternal depression; maternal risk; novel; novel strategies; offspring; participant enrollment; postnatal; prenatal; prevent; programs; prospective; protective factors; psychological distress; psychosocial; psychosocial stressors; public health relevance; racial minority; resilience; resilience factor; response; serotonin transporter; social; socioeconomic disadvantage; violence exposure

PROJECT SUMMARY Despite improvements in access and quality of health care in the United States (US), children from socioeconomically disadvantaged families and / or of minority race have an elevated risk for impaired cognitive and social-emotional development. Indeed, children in poverty are 40% more likely to experience developmental delays relative to children not in poverty. Poverty engenders disproportionate exposure to adversity including parental/child psychosocial stressors (such as, exposure to violence, frequent relocation) and psychological distress (such as, maternal depression) that contribute to impaired childhood development. However, negative effects may be mitigated in the presence of protective factors. While measures of maternal adversity and protective factors have been evaluated in association with child development, the combined effects of these opposing forces and the potentially related and critical role of epigenetic programming have not been determined. In particular, at sensitive periods across the life-course when their effects have the strongest impact. Our preliminary data suggest that maternal adversity during two sensitive time periods (prenatally and early life) epigenetically program infant response systems, thereby altering child development. Our overall hypothesis is that maternal adversity and protective factors (i.e., maternal psychosocial experience) faced across the life- course contribute to offspring cognitive and social-emotional developmental disparities through DNA methylation (DNAm) of genes in multiple biologic pathways. This study combines retrospective assessment and prospective data collection on 375 mother-infant dyads captured in 5 study visits spanning pregnancy through 18 months postnatal. The specific aims of the proposal are 1) determine the association between the life-course maternal psychosocial experience and the change in infant DNAm during the first year of life, a sensitive developmental window, 2) characterize the association between postnatal maternal psychosocial experiences in the infant’s first year of life and infant DNAm at one year, and 3) determine the impact of DNAm at two time points (1 month and 12 months) of infant development across the first 18 months. This research will be conducted within a large, regional home visiting program, uniquely positioning us to translate findings through precision home visiting and additional strategies aimed at reducing early developmental health disparities.

项目摘要 尽管美国（美国）的医疗保健获得和质量有所改善，但 社会经济上处于弱势家庭和 /或少数族裔种族的认知风险较高 和社会情感发展。确实，贫困的儿童体验发展的可能性高40％ 相对于不贫穷的孩子的延迟。贫困导致广告不成比例的接触 父母/儿童的社会心理压力源（例如暴露暴力，经常搬迁）和心理 遇到造成儿童发展受损的苦难（例如，孕产妇抑郁症）。但是，负面 在存在受保护因素的情况下，可以减轻效果。而孕产妇广告的措施和 保护因素已与儿童发育有关，这些因素的综合作用 尚未确定对立力和表观遗传编程的潜在相关和关键作用。 特别是，在整个生命过程中的敏感时期，其影响最大。我们的 初步数据表明，在两个敏感时期（产前和早期生活）期间的物物广告 表观遗传学对婴儿反应系统进行了编程，从而改变了儿童发育。我们的总体假设是 在整个生活中面临的物物广告和受保护因素（即产妇的社会心理经验） - 课程通过DNA甲基化有助于后代认知和社会情感发展差异 多种生物学途径中基因的（DNAM）。这项研究结合了回顾性评估和前瞻性 在5个研究访问中捕获的375个母亲二元组的数据收集跨越18个月 产后。该提案的具体目的是1）确定生命课程的孕产妇之间的关联 心理社会经验和婴儿DNAN在生命的第一年的变化，这是一种敏感的发展 窗口，2）表征婴儿第一次产后孕产妇的心理社会体验之间的关联 一年的生命年和婴儿DNAN，3）确定DNA在两个时间点的影响（1个月和1个月 12个月）在最初的18个月中的婴儿发育。这项研究将在大型的 区域家庭访问计划，独特地定位我们以通过精密家庭访问和 旨在减少早期发展健康分布的其他策略。

项目成果

Pregnancy and Infant Development (PRIDE)-a preliminary observational study of maternal adversity and infant development.

• DOI: 10.1186/s12887-021-02801-1
• 发表时间: 2021-10-15
• 期刊: BMC pediatrics
• 影响因子: 2.4
• 作者: Bowers K;Ding L;Yolton K;Ji H;Nidey N;Meyer J;Ammerman RT;Van Ginkel J;Folger A
• 通讯作者: Folger A