Bioenergetics Core

生物能核心

基本信息

批准号：
10574558
负责人：
Suresh Kumar Krishnaswamy Thallapuranam
金额：
$ 30.14万
依托单位：
UNIVERSITY OF ARKANSAS AT FAYETTEVILLE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-01 至 2026-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10574558
关键词：
ATP Synthesis Pathway Acceleration Aging Applications Grants Arkansas Bioenergetics Biological Assay Biological Models Biomedical Research Cells Cellular Metabolic Process Centers of Research Excellence Collaborations Communities Complement Consultations Coupling Data Analyses Data Science Core Disease Education Educational workshop Energy Metabolism Experimental Designs Flow Cytometry Fostering Foundations Future Generations Glycolysis Goals Grant Health Image Industry Institution Malignant Neoplasms Measurement Measures Membrane Potentials Metabolic Metabolic Pathway Metabolism Mitochondria Mitochondrial Diseases Oxygen Consumption Pathway interactions Phase Preparation Proton-Motive Force Protons Publications Reactive Oxygen Species Research Research Methodology Research Personnel Resolution Respiration Role Sampling Services Spectrum Analysis Structure Techniques Technology Tissues Training United States National Institutes of Health Universities Vision clinical translation data acquisition design experimental study imaging facilities imaging science innovation insight instrument interdisciplinary collaboration member mitochondrial membrane mitochondrial metabolism novel programs respiratory synergism wound healing

项目摘要

Project Summary – Bioenergetics Core Bioenergetic measurements using contemporary live-cell metabolic assay platforms provides insights into various parameters of energy metabolism. Complemented by established flow cytometry assay platforms to measure different mitochondrial and cellular functional parameters, the Bioenergetics (Bio-E) core will form a key component of Arkansas Integrative Metabolic Research Center (AIMRC). The Bio-E core will be a new core created to meet the metabolic research needs of the proposed COBRE center. The Bio-E core will coordinate closely with the AIMRC Imaging and Spectroscopy and Data Science Cores to generate a cross-disciplinary framework and allow project leaders to shed new light on cell and tissue metabolism, thus enabling novel discoveries, as well as clinical translation of such discoveries. Close collaborative interactions between the Bio- E Core and COBRE project leaders as well as the Imaging and Spectroscopy and Data Science Cores will lead to new innovations in research methods that will benefit future COBRE investigators as well as the broader campus research community. Hands-on training in live-cell metabolic assays and flow cytometry technologies will be provided to Center members, the campus and biomedical researchers in Arkansas.

项目摘要 – 生物能量学核心使用当代活细胞代谢测定平台进行生物能测量可提供以下见解：通过已建立的流式细胞仪检测平台补充能量代谢的各种参数。测量不同的线粒体和细胞功能参数，生物能量学（Bio-E）核心将形成一个阿肯色州综合代谢研究中心 (AIMRC) 的关键组成部分 Bio-E 核心将是一个新的核心。为满足拟建 COBRE 中心的代谢研究需求而创建，Bio-E 核心将进行协调。与 AIMRC 成像、光谱学和数据科学核心密切合作，形成跨学科的框架并允许项目领导者对细胞和组织代谢提供新的认识，从而实现新的发现，以及这些发现的临床转化。 E Core 和 COBRE 项目负责人以及成像、光谱和数据科学核心将领导研究方法的新创新将使未来的 COBRE 研究人员以及更广泛的研究人员受益校园研究社区。活细胞代谢测定和流式细胞术技术的实践培训。将提供给中心成员、校园和阿肯色州的生物医学研究人员。