LOW-CHO & HIGH-CHO, HIGH-FIBER DIETS & RISK MARKERS FOR THE METABOLIC SYNDROME

低CHO

• 批准号: 7718547
• 负责人: GLENN A GAESSER
• 金额: $ 4.65万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718547
• 关键词: Blood; Blood Pressure; C-reactive protein; Carbohydrates; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Crossover Design; Daily; Diet; E-Selectin; Eating; Equation; Fatty acid glycerol esters; Fiber; Fibrinogen; Food; Funding; Grant; Homocysteine; Homocystine; Institution; Intercellular adhesion molecule 1; Interleukin-1; Interleukin-6; LDL Cholesterol Lipoproteins; Leukocyte-Adhesion Receptors; Measures; Mediating; Metabolic syndrome; Muscle function; Participant; Proteins; Randomized; Research; Research Personnel; Resources; Risk Marker; Source; Tumor Necrosis Factor-alpha; United States National Institutes of Health; Vascular Cell Adhesion Molecule-1; Week; Woman; adiponectin; cardiovascular disorder risk; cytokine; day; human TNF protein; improved; indexing; insulin sensitivity; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study is to compare an ad libitum low-carbohydrate diet with an libitum high-carbohydrate, high-fiber diet with regard to insulin sensitivity and blood markers for cardiovascular disease risk in men and women with the metabolic syndrome. In a randomized crossover design, 24 men and women with the metabolic syndrome will consume each of two diets: a low-carbohydrate diet (15-20% carbohydrate; 55-60% fat; 25-30 protein) and a high-carbohydrate, high-fiber diet (55-60% carbohydrate; 20-25% fat; 15-20% protein; > 30 grams fiber per day). Each diet period will last 4 weeks, with a 4-6 week wash-out period. All meals will be prepared in the General Clinical Research Center (GCRC) kitchen for pick-up three days per week by the participants, and will contain 150% of daily energy requirements estimated by the Harris-Benedict equation. Participants will be instructed to eat only until no longer hungry, and to return uneaten food to the GCRC. We hypothesize that that the ad libitum high-carbohydrate, high-fiber diet will significantly improve insulin sensitivity assessed by the Quantitative Insulin sensitivity Check Index (QUICKI), enhance arterial endothelial and smooth muscle function (as measured by flow-mediated dilation); increase blood concentration of adiponectin; and reduce blood concentrations of total and LDL-cholesterol, C-reactive protein, homocysteine, fibrinogen, cytokines (IL-1, IL-2, IL-6 and TNF-alpha), leukocyte adhesion molecules(E-selectin, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1)), and blood pressure; whereas the ad libitum low-carbohydrate, low-fiber diet will not.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目的是比较随意低碳水化合物饮食与随意高碳水化合物、高纤维饮食对患有代谢综合征的男性和女性心血管疾病风险的胰岛素敏感性和血液标志物的影响。 在随机交叉设计中，24 名患有代谢综合征的男性和女性将分别食用两种饮食：低碳水化合物饮食（15-20% 碳水化合物；55-60% 脂肪；25-30 蛋白质）和高碳水化合物饮食，高纤维饮食（55-60%碳水化合物；20-25%脂肪；15-20%蛋白质；每天> 30克纤维）。 每个节食期将持续 4 周，并有 4-6 周的清除期。 所有膳食将在综合临床研究中心 (GCRC) 的厨房中准备，供参与者每周三天领取，并且将包含根据 Harris-Benedict 方程估计的每日能量需求的 150%。 参与者将被指示只吃东西直到不再饥饿，并将未吃的食物归还给 GCRC。 我们假设，随意的高碳水化合物、高纤维饮食将显着改善通过定量胰岛素敏感性检查指数（QUICKI）评估的胰岛素敏感性，增强动脉内皮和平滑肌功能（通过血流介导的扩张测量）；增加脂联素的血液浓度；降低总胆固醇和低密度脂蛋白胆固醇、C反应蛋白、同型半胱氨酸、纤维蛋白原、细胞因子（IL-1、IL-2、IL-6和TNF-α）、白细胞粘附分子（E-选择素、细胞间粘附分子）的血液浓度1 (ICAM-1) 和血管细胞粘附分子 1 (VCAM-1)) 和血压；而随意摄入低碳水化合物、低纤维饮食则不会。