LOW-CHO & HIGH-CHO, HIGH-FIBER DIETS & RISK MARKERS FOR THE METABOLIC SYNDROME

低CHO

• 批准号: 7606693
• 负责人: GLENN A GAESSER
• 金额: $ 3.21万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7606693
• 关键词: Arteries; Blood; Caloric Restriction; Calories; Carbohydrates; Cardiovascular system; Cholesterol; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Condition; Crossover Design; Daily; Diet; Eating; Fatty acid glycerol esters; Fiber; Food; Forearm; Funding; Glucose; Grant; Health; Heart Diseases; Inflammation; Institution; Insulin; Metabolic; Metabolic syndrome; Outcome Measure; Participant; Procedures; Proteins; Randomized; Research; Research Personnel; Resources; Risk Marker; Source; Triglycerides; Ultrasonography; United States National Institutes of Health; Week; Woman; cardiovascular disorder risk; day; diabetes risk; improved; insulin sensitivity; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study is to compare a low-carbohydrate diet with high-carbohydrate, high-fiber diet-with no emphasis on calorie restriction--with regard to insulin sensitivity and blood markers for cardiovascular disease risk in men and women with the metabolic syndrome. In a randomized crossover design, men and women with the metabolic syndrome (i.e., a metabolic condition associated with increased risk for diabetes and heart disease) will consume each of two diets: a low-carbohydrate diet (15-20% carbohydrate; 55-60% fat; 25-30 protein) and a high-carbohydrate, high-fiber diet (55-60% carbohydrate; 20-25% fat; 15-20% protein; > 30 grams fiber per day). Each diet period will last 4 weeks, with a 4-6 week wash-out period. All meals will be prepared in the General Clinical Research Center (GCRC) kitchen for pick-up three days per week by the participants, and will contain more than enough calories to meet daily energy needs. Participants will be instructed to eat only until no longer hungry, and to return uneaten food to the GCRC. We hypothesize that that the high-carbohydrate, high-fiber diet will significantly improve insulin sensitivity and enhance cardiovascular health, and the low-carbohydrate diet will not. Outcome measures include blood levels of insulin, glucose, cholesterol, triglycerides, and several markers of inflammation, as well as an ultrasound procedure to examine endothelial function of a forearm artery.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目的是比较低碳水化合物饮食与高碳水化合物、高纤维饮食（不强调热量限制）对于患有代谢性糖尿病的男性和女性心血管疾病风险的胰岛素敏感性和血液标志物的影响。综合症。 在随机交叉设计中，患有代谢综合征（即与糖尿病和心脏病风险增加相关的代谢状况）的男性和女性将分别食用两种饮食：低碳水化合物饮食（15-20%碳水化合物；55- 60% 脂肪；25-30 蛋白质）和高碳水化合物、高纤维饮食（55-60% 碳水化合物；20-25% 脂肪；15-20% 蛋白质；> 30每天克纤维）。 每个节食期将持续 4 周，并有 4-6 周的清除期。 所有餐食将在综合临床研究中心 (GCRC) 厨房准备，每周三天由参与者取用，并且包含足够的卡路里来满足日常能量需求。 参与者将被指示只吃东西直到不再饥饿，并将未吃的食物归还给 GCRC。 我们假设高碳水化合物、高纤维饮食将显着提高胰岛素敏感性并增强心血管健康，而低碳水化合物饮食则不会。 结果测量包括胰岛素、葡萄糖、胆固醇、甘油三酯的血液水平和多种炎症标志物，以及检查前臂动脉内皮功能的超声检查。